1.1.1.79: glyoxylate reductase (NADP+)
This is an abbreviated version!
For detailed information about glyoxylate reductase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.79
Reaction
Synonyms
aac4036, At3g25530, AtGLYR1, AtGLYR2, AtGR1, AtGR2, D-2-hydroxy-acid dehydrogenase, GhrA, glycerate dehydrogenase, glyoxylate reductase, glyoxylate reductase 1, glyoxylate reductase 2, glyoxylate reductase isoform 1, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate/succinic semialdehyde reductase, GLYR1, GLYR2, GOR1, Gor1p, GR/HPR, GR1, GR2, GRHPR, GRHRP, HPR2, HPR3, More, NAD(P)H-dependent GR, NADPH/NADH-dependent glyoxylate/hydroxypyruvate reductases, PfuGRHPR, PhoGRHPR, PtGR, PyaGRHPR, TthGR1
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Reference on EC 1.1.1.79 - glyoxylate reductase (NADP+)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yokota, A.; Kitaoka, S.
Occurrence and subcellular distribution of enzymes involved in the glycolate pathway and their physiological function in a bleached mutant of Euglena gracilis Z
Agric. Biol. Chem.
45
15-22
1981
Euglena gracilis
-
Kleczkowski, L.A.
Kinetics and regulation of the NAD(P)H-dependent glyoxylate-specific reductase from spinach leaves
Z. Naturforsch. C
50
21-28
1995
Spinacia oleracea
-
Husic, D.W.; Tolbert, N.E.
NADH:hydroxypyruvate reductase and NADPH:glyoxylate reductase in algae: partial purification and characterization from Chlamydomonas reinhardtii
Arch. Biochem. Biophys.
252
396-408
1987
Chlamydomonas reinhardtii
Kleczkowski, L.A.; Randall, D.D.; Blevins, D.G.
Purification and characterization of a novel NADPH(NADH)-dependent glyoxylate reductase from spinach leaves. Comparison of immunological properties of leaf glyoxylate reductase and hydroxypyruvate reductase
Biochem. J.
239
653-659
1986
Glycine max, Spinacia oleracea, Triticum aestivum
Yokota, A.; Haga, S.; Kitaoka, S.
Purification and some properties of glyoxylate reductase (NADP+) and its functional location in mitochondria in Euglena gracilis Z
Biochem. J.
227
211-216
1985
Euglena gracilis
Mulligan, R.M.; Wilson, B.; Tolbert, N.E.
Effects of glyoxylate on photosynthesis by intact chloroplasts
Plant Physiol.
72
415-419
1983
Spinacia oleracea
Fukuda, H.; Moriguchi, M.; Kimura, A.; Tochikura, T.
Purification and properties of glyoxylate reductase from Neurospora crassa
Agric. Biol. Chem.
45
1153-1158
1981
Neurospora crassa
-
Fukuda, H.; Moriguchi, M.; Tochikura, T.
Purification and enzymatic properties of glyoxylate reductase II from baker's yeast
J. Biochem.
87
841-846
1980
Saccharomyces cerevisiae
Sagisaka, S.
Occurrence of nicotinamide adenine dinucleotide phosphate-linked glyoxylate reductase in nonphotosynthetic xylem tissue of perennials
Plant Physiol.
65
377-381
1980
Populus gelrica
Yokota, A.; Kitaoka, S.
Occurrence and properties of the glycollate-glyoxylate shuttle in mitochondria of Euglena gracilis z
Biochem. J.
184
189-192
1979
Euglena gracilis
Tochikura, T.; Fukuda, H.; Moriguchi, M.
Purification and properties of glyoxylate reductase I from baker's yeast
J. Biochem.
86
105-110
1979
Saccharomyces cerevisiae
Zeltich, I.
Effect of glycidate, an inhibitor of glycolate synthesis in leaves, on the activity of some enzymes of the glycolate pathway
Plant Physiol.
61
236-241
1978
Nicotiana tabacum
Mdluli, K.; Booth, M.P.; Brady, R.L.; Rumsby, G.
A preliminary account of the properties of recombinant human glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism
Biochim. Biophys. Acta
1753
209-216
2005
Homo sapiens
Genolet, R.; Kersten, S.; Braissant, O.; Mandard, S.; Tan, N.S.; Bucher, P.; Desvergne, B.; Michalik, L.; Wahli, W.
Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha
J. Biol. Chem.
280
24143-24152
2005
Homo sapiens, Mus musculus
Booth, M.P.; Conners, R.; Rumsby, G.; Brady, R.L.
Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase
J. Mol. Biol.
360
178-189
2006
Homo sapiens
Yoshikawa, S.; Arai, R.; Kinoshita, Y.; Uchikubo-Kamo, T.; Wakamatsu, T.; Akasaka, R.; Masui, R.; Terada, T.; Kuramitsu, S.; Shirouzu, M.; Yokoyama, S.
Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate
Acta Crystallogr. Sect. D
63
357-365
2007
Pyrococcus horikoshii OT3
Ogino, H.; Nakayama, H.; China, H.; Kawata, T.; Doukyu, N.; Yasuda, M.
Characterization of recombinant glyoxylate reductase from thermophile Thermus thermophilus HB27
Biotechnol. Prog.
24
321-325
2008
Thermus thermophilus, Thermus thermophilus HB27, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Hoover, G.J.; Prentice, G.A.; Merrill, A.R.; Shelp, B.J.
Kinetic mechanism of a recombinant Arabidopsis glyoxylate reductase: studies of initial velocity, dead-end inhibition and product inhibition
Can. J. Bot.
85
896-902
2007
Arabidopsis thaliana (Q9LSV0)
Simpson, J.P.; Di Leo, R.; Dhanoa, P.K.; Allan, W.L.; Makhmoudova, A.; Clark, S.M.; Hoover, G.J.; Mullen, R.T.; Shelp, B.J.
Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification
J. Exp. Bot.
59
2545-2554
2008
Arabidopsis thaliana (F4I907), Arabidopsis thaliana (Q9LSV0), Arabidopsis thaliana
Allan, W.L.; Simpson, J.P.; Clark, S.M.; Shelp, B.J.
Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms
J. Exp. Bot.
59
2555-2564
2008
Arabidopsis thaliana, Nicotiana tabacum
Rintala, E.; Pitkanen, J.; Vehkomaki, M.; Penttila, M.; Ruohonen, L.
The ORF YNL274c (GOR1) codes for glyoxylate reductase in Saccharomyces cerevisiae
Yeast
24
129-136
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Allan, W.L.; Clark, S.M.; Hoover, G.J.; Shelp, B.J.
Role of plant glyoxylate reductases during stress: a hypothesis
Biochem. J.
423
15-22
2009
Arabidopsis thaliana
Ching, S.L.; Gidda, S.K.; Rochon, A.; van Cauwenberghe, O.R.; Shelp, B.J.; Mullen, R.T.
Glyoxylate reductase isoform 1 is localized in the cytosol and not peroxisomes in plant cells
J. Integr. Plant Biol.
54
152-168
2012
Arabidopsis thaliana (Q9LSV0)
Hoover, G.J.; Jorgensen, R.; Rochon, A.; Bajwa, V.S.; Merrill, A.R.; Shelp, B.J.
Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants
Biochim. Biophys. Acta
1834
2663-2671
2013
Arabidopsis thaliana (A0A178WMD4), Arabidopsis thaliana (F4I907), Arabidopsis thaliana (Q9CA90), Arabidopsis thaliana (Q9LSV0), Arabidopsis thaliana
Pan, Y.; Ni, R.; Deng, Q.; Huang, X.; Zhang, Y.; Lu, C.; Li, F.; Huang, D.; He, S.; Chen, B.
Glyoxylate reductase/hydroxypyruvate reductase: a novel prognostic marker for hepatocellular carcinoma patients after curative resection
Pathobiology
80
155-162
2013
Homo sapiens (Q9UBQ7)
Zong, C.; Nie, X.; Zhang, D.; Ji, Q.; Qin, Y.; Wang, L.; Jiang, D.; Gong, C.; Liu, Y.; Zhou, G.
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis
Pathol. Res. Pract.
212
365-371
2016
Homo sapiens (Q9UBQ7), Homo sapiens
Lassalle, L.; Engilberge, S.; Madern, D.; Vauclare, P.; Franzetti, B.; Girard, E.
New insights into the mechanism of substrates trafficking in glyoxylate/hydroxypyruvate reductases
Sci. Rep.
6
20629
2016
Pyrococcus horikoshii, Pyrococcus yayanosii (F8AEA4), Pyrococcus furiosus (Q8U3Y2), Pyrococcus yayanosii CH1 (F8AEA4)
Cahn, J.K.; Werlang, C.A.; Baumschlager, A.; Brinkmann-Chen, S.; Mayo, S.L.; Arnold, F.H.
A general tool for engineering the NAD/NADP cofactor preference of oxidoreductases
ACS Synth. Biol.
6
326-333
2016
Arabidopsis thaliana (Q9LSV0)
Duan, X.; Hu, S.; Zhou, P.; Zhou, Y.; Liu, Y.; Jiang, Z.
Characterization and crystal structure of a first fungal glyoxylate reductase from Paecilomyes thermophila
Enzyme Microb. Technol.
60
72-79
2014
Paecilomyces sp. 'thermophila' (A0A0H3U0Y7), Paecilomyces sp. 'thermophila', Paecilomyces sp. 'thermophila' J18 (A0A0H3U0Y7)
Cahn, J.K.; Werlang, C.A.; Baumschlager, A.; Brinkmann-Chen, S.; Mayo, S.L.; Arnold, F.H.
A general tool for engineering the NAD/NADP cofactor preference of oxidoreductases
ACS Synth. Biol.
6
326-333
2017
Arabidopsis thaliana (Q9LSV0)
Kutner, J.; Shabalin, I.G.; Matelska, D.; Handing, K.B.; Gasiorowska, O.; Sroka, P.; Gorna, M.W.; Ginalski, K.; Wozniak, K.; Minor, W.
Structural, biochemical, and evolutionary characterizations of glyoxylate/hydroxypyruvate reductases show their division into two distinct subfamilies
Biochemistry
57
963-977
2018
Sinorhizobium meliloti
Kumsab, J.; Tobe, R.; Kurihara, T.; Hirose, Y.; Omori, T.; Mihara, H.
Characterization of a novel class of glyoxylate reductase belonging to the beta-hydroxyacid dehydrogenase family in Acetobacter aceti
Biosci. Biotechnol. Biochem.
84
2303-2310
2020
Acetobacter aceti, Acetobacter aceti JCM20276
Zhang, Z.; Liang, X.; Lu, L.; Xu, Z.; Huang, J.; He, H.; Peng, X.
Two glyoxylate reductase isoforms are functionally redundant but required under high photorespiration conditions in rice
BMC Plant Biol.
20
357
2020
Oryza sativa Japonica Group
Zarei, A.; Brikis, C.J.; Bajwa, V.S.; Chiu, G.Z.; Simpson, J.P.; DeEll, J.R.; Bozzo, G.G.; Shelp, B.J.
Plant glyoxylate/succinic semialdehyde reductases comparative biochemical properties, function during chilling stress, and subcellular localization
Front. Plant Sci.
8
1399
2017
Oryza sativa, Malus domestica (A0A1C8M582), Malus domestica (A0A1C8M593), Arabidopsis thaliana (F4I907), Arabidopsis thaliana (Q9LSV0)
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