1.1.1.87: homoisocitrate dehydrogenase
This is an abbreviated version!
For detailed information about homoisocitrate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.87
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1.1.1.87
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alpha-aminoadipate
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3-isopropylmalate
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homocitrate
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homoaconitase
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beta-decarboxylating
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alpha-ketoadipate
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medicine
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synthesis
- 1.1.1.87
- alpha-aminoadipate
- 3-isopropylmalate
- homocitrate
- homoaconitase
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beta-decarboxylating
- alpha-ketoadipate
- medicine
- synthesis
Reaction
Synonyms
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), beta-decarboxylating dehydrogenase, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, LYS12, protein PH1722, ScHICDH, TK0280
ECTree
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Inhibitors
Inhibitors on EC 1.1.1.87 - homoisocitrate dehydrogenase
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(2S,3S)-thiahomoisocitrate
interacts through hydrogen bonding to Arg 118, Tyr 125 and Lys 171 in the active site, enzyme binding structure, overview
3-acetylpyridine adenine dinucleotide 3'-phosphate
3-AcPyrADP, competitive versus NAD+
NAD+
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substrate inhibition at high concentrations and in absence of K+, kinetics, overview
trisodium (2S,3R)-2-[(carboxylatomethyl)amino]-3-hydroxybutanedioate
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trisodium (2S,3S)-2-[(carboxylatomethyl)sulfanyl]-3-hydroxybutanedioate
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inhibitor docking study, molecular modeling of CaHIcDH-inhibitor interaction, overview
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additional information
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synthesis and inhibition potency of substrate analogue inhibitors derived from 3-hydroxyalkylidene- and 3-carboxyalkylidenemalate derivatives, overview
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additional information
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synthesis and inhibition potency of substrate analogue inhibitors derived from 3-hydroxyalkylidene- and 3-carboxyalkylidenemalate derivatives, overview, no inhibition by 3-vinylmalate
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additional information
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product and dead-end inhibition studies in the absence of K+
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