EC 1.1.1.87: homoisocitrate dehydrogenase
This is an abbreviated version!
For detailed information about homoisocitrate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.87
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1.1.1.87
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alpha-aminoadipate
-
3-isopropylmalate
-
homocitrate
-
homoaconitase
-
beta-decarboxylating
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alpha-ketoadipate
-
medicine
-
synthesis
- 1.1.1.87
- alpha-aminoadipate
- 3-isopropylmalate
- homocitrate
- homoaconitase
-
beta-decarboxylating
- alpha-ketoadipate
- medicine
- synthesis
Reaction
Synonyms
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), beta-decarboxylating dehydrogenase, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, LYS12, protein PH1722, ScHICDH, TK0280
ECTree
1.1.1.87 homoisocitrate dehydrogenaseAdvanced search results
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results (KCat KM Value
KCat KM Value on EC 1.1.1.87 - homoisocitrate dehydrogenase
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kcat/KM VALUE [1/mMs-1] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.022
D-malate
-
wild type enzyme, with NAD+ as cosubstrate, at pH 8.0 and 60°C
1.6
NADP+
-
wild type enzyme, with homoisocitrate as cosubstrate, at pH 8.0 and 60°C
5.16
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
-
recombinant His-tagged enzyme, pH 7.8, 20°C
8.75
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
-
native enzyme, pH 7.8, 20°C
2.2
3-isopropylmalate
-
mutant enzyme L81P, with NAD+ as cosubstrate, at pH 8.0 and 60°C
13
3-isopropylmalate
-
mutant enzyme T71V, with NAD+ as cosubstrate, at pH 8.0 and 60°C
15
3-isopropylmalate
-
wild type enzyme, with NAD+ as cosubstrate, at pH 8.0 and 60°C
46
3-isopropylmalate
-
mutant enzyme S80A, with NAD+ as cosubstrate, at pH 8.0 and 60°C
5.1
homoisocitrate
-
mutant enzyme T71V, with NAD+ as cosubstrate, at pH 8.0 and 60°C
98
homoisocitrate
-
mutant enzyme I82N, with NAD+ as cosubstrate, at pH 8.0 and 60°C
190
homoisocitrate
-
wild type enzyme, with NADP+ as cosubstrate, at pH 8.0 and 60°C
190
homoisocitrate
-
mutant enzyme S80A, with NAD+ as cosubstrate, at pH 8.0 and 60°C
250
homoisocitrate
-
mutant enzyme L83R, with NAD+ as cosubstrate, at pH 8.0 and 60°C
310
homoisocitrate
-
mutant enzyme L81P, with NAD+ as cosubstrate, at pH 8.0 and 60°C
2300
homoisocitrate
-
wild type enzyme, with NAD+ as cosubstrate, at pH 8.0 and 60°C
0.44
isocitrate
-
mutant enzyme T71V, with NAD+ as cosubstrate, at pH 8.0 and 60°C
0.45
isocitrate
-
mutant enzyme I82N, with NAD+ as cosubstrate, at pH 8.0 and 60°C
0.92
isocitrate
-
mutant enzyme L81P, with NAD+ as cosubstrate, at pH 8.0 and 60°C
2.4
isocitrate
-
mutant enzyme S80A, with NAD+ as cosubstrate, at pH 8.0 and 60°C
11
isocitrate
-
mutant enzyme L83R, with NAD+ as cosubstrate, at pH 8.0 and 60°C
360
isocitrate
-
wild type enzyme, with NAD+ as cosubstrate, at pH 8.0 and 60°C
0.11
NAD+
-
wild type enzyme, with D-malate as cosubstrate, at pH 8.0 and 60°C
0.56
NAD+
-
mutant enzyme I82N, with isocitrate as cosubstrate, at pH 8.0 and 60°C
0.88
NAD+
-
mutant enzyme T71V, with isocitrate as cosubstrate, at pH 8.0 and 60°C
0.93
NAD+
-
mutant enzyme S80A, with isocitrate as cosubstrate, at pH 8.0 and 60°C
1.2
NAD+
-
mutant enzyme L81P, with 3-isopropylmalate as cosubstrate, at pH 8.0 and 60°C
1.8
NAD+
-
mutant enzyme L81P, with isocitrate as cosubstrate, at pH 8.0 and 60°C
1.9
NAD+
-
mutant enzyme S80A, with 3-isopropylmalate as cosubstrate, at pH 8.0 and 60°C
3.2
NAD+
-
wild type enzyme, with 3-isopropylmalate as cosubstrate, at pH 8.0 and 60°C
3.2
NAD+
-
mutant enzyme T71V, with homoisocitrate as cosubstrate, at pH 8.0 and 60°C
7.5
NAD+
-
mutant enzyme S80A, with homoisocitrate as cosubstrate, at pH 8.0 and 60°C
9.4
NAD+
-
mutant enzyme T71V, with 3-isopropylmalate as cosubstrate, at pH 8.0 and 60°C
11
NAD+
-
mutant enzyme L83R, with isocitrate as cosubstrate, at pH 8.0 and 60°C
41
NAD+
-
mutant enzyme L81P, with homoisocitrate as cosubstrate, at pH 8.0 and 60°C
50
NAD+
-
wild type enzyme, with isocitrate as cosubstrate, at pH 8.0 and 60°C
70
NAD+
-
mutant enzyme I82N, with homoisocitrate as cosubstrate, at pH 8.0 and 60°C
270
NAD+
-
mutant enzyme L83R, with homoisocitrate as cosubstrate, at pH 8.0 and 60°C
470
NAD+
-
wild type enzyme, with homoisocitrate as cosubstrate, at pH 8.0 and 60°C
