1.1.1.88: hydroxymethylglutaryl-CoA reductase
This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Word Map on EC 1.1.1.88
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1.1.1.88
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cholesterol
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statin
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lipoprotein
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sterol
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cardiovascular
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low-density
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simvastatin
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coronary
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atorvastatin
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lovastatin
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pravastatin
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hypercholesterolemia
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lipid-lowering
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cerivastatin
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mevinolin
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3-hydroxy-3-methylglutaryl-coa
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cholesterol-lowering
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mevalonolactone
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rosuvastatin
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alpha-hydroxylase
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medicine
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cholestyramine
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25-hydroxycholesterol
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fibric
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lipoprotein-deficient
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mevalonii
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hscrp
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cholesterogenesis
- 1.1.1.88
- cholesterol
- statin
- lipoprotein
- sterol
- cardiovascular
-
low-density
- simvastatin
- coronary
- atorvastatin
- lovastatin
- pravastatin
- hypercholesterolemia
-
lipid-lowering
- cerivastatin
- mevinolin
- 3-hydroxy-3-methylglutaryl-coa
-
cholesterol-lowering
- mevalonolactone
- rosuvastatin
-
alpha-hydroxylase
- medicine
- cholestyramine
- 25-hydroxycholesterol
-
fibric
-
lipoprotein-deficient
-
mevalonii
-
hscrp
-
cholesterogenesis
Reaction
Synonyms
3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, NADH-dependent HMG-CoA reductase
ECTree
Advanced search results
Results
in table
5
4935
17
14
36
15
Engineering
Engineering on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase
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H381K
H381N
H381Q
additional information
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decreasing HMGR1 expression in Medicago truncatula transgenic roots by RNA interference leads to a dramatic decrease in nodulation, confirming that HMGR1 is essential for nodule development; using Medicago truncatula NORK, a receptor-like kinase, as bait in a yeast two-hybrid assay, Mt HMGR1 is identified as a NORK interacting partner. Mutagenesis and deletion analysis show that this interaction requires the cytosolic active kinase domain of NORK and the cytosolic catalytic domain of HMGR1