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1.1.1.95: phosphoglycerate dehydrogenase

This is an abbreviated version!
For detailed information about phosphoglycerate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.95

Reaction

3-phospho-D-glycerate
+
NAD+
=
3-phosphooxypyruvate
+
NADH
+
H+

Synonyms

3-PGDH, 3-phosphoglycerate dehydrogenase, 3-phosphoglyceric acid dehydrogenase, 3PGDH, A10, alpha-phosphoglycerate dehydrogenase, ApPGDH, At1g17745, At3g19480, At4g34200, BvSHMTa, BvSHMTb, D-3-PG dehydrogenase, D-3-phosphoglycerate dehydrogenase, D-3-phosphoglycerate:NAD oxidoreductase, D-phosphoglycerate dehydrogenase, dehydrogenase, phosphoglycerate, EDA9, EhPGDH, glycerate 3-phosphate dehydrogenase, glycerate-1,3-phosphate dehydrogenase, MARPO_0030s0029, More, NAD-dependent D-3-phosphoglycerate dehydrogenase, PGDH, PGDH1, PGDH2, PGDH3, PGK, Phgdh, phosphoglycerate dehydrogenase, phosphoglycerate kinase, phosphoglycerate oxidoreductase, phosphoglyceric acid dehydrogenase, Rv2996c, serA, serA1, type 1 D-3-phosphoglycerate dehydrogenase, type III 3-phosphoglycerate dehydrogenase, type IIIK PGDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.95 phosphoglycerate dehydrogenase

Expression

Expression on EC 1.1.1.95 - phosphoglycerate dehydrogenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a sericin-deficient silkworm strain displays reduced expression of bmphgdh mRNA
AtPGDH1 gene is coexpressed with genes of tryptophan biosynthesis. Activators of tryptophan biosynthesis MYB51 and MYB34 are involved in the expression of AtPGDH1
HOXA10 is required for enzyme regulation in the endometrium, HOAX antisense expression, siRNA, causes a 4.4fold upregulation of 3-PGDH in endometrial cells
HOXA10 is required for enzyme regulation in the endometrium, HOAX sense expression causes a 2.0fold downregulation of 3-PGDH in endometrial cells
mRNA transcriptional expression for BvPGDHa is significantly enhanced under salt stress conditions in both leaves and roots
mRNA transcriptional expression for BvPGDHb is significantly reduced under salt stress conditions
Phgdh knockout mouse embryos demonstrate that free serine and glycine concentrations are decreased markedly in head samples
-
the enzyme is highly expressed in tumors as a result of amplification, transcription, or its degradation and stability alteration, which dysregulates the serine biosynthesis pathway via metabolic enzyme activity to nourish tumors. High expression of the enzyme is dramatically related to tumor resistance to chemotherapies
there is no significant change in the mRNA expression level after the incubation with L-serine