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1.1.1.95: phosphoglycerate dehydrogenase

This is an abbreviated version!
For detailed information about phosphoglycerate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.95

Reaction

3-phospho-D-glycerate
+
NAD+
=
3-phosphooxypyruvate
+
NADH
+
H+

Synonyms

3-PGDH, 3-phosphoglycerate dehydrogenase, 3-phosphoglyceric acid dehydrogenase, 3PGDH, A10, alpha-phosphoglycerate dehydrogenase, ApPGDH, At1g17745, At3g19480, At4g34200, BvSHMTa, BvSHMTb, D-3-PG dehydrogenase, D-3-phosphoglycerate dehydrogenase, D-3-phosphoglycerate:NAD oxidoreductase, D-phosphoglycerate dehydrogenase, dehydrogenase, phosphoglycerate, EDA9, EhPGDH, glycerate 3-phosphate dehydrogenase, glycerate-1,3-phosphate dehydrogenase, MARPO_0030s0029, More, NAD-dependent D-3-phosphoglycerate dehydrogenase, PGDH, PGDH1, PGDH2, PGDH3, PGK, Phgdh, phosphoglycerate dehydrogenase, phosphoglycerate kinase, phosphoglycerate oxidoreductase, phosphoglyceric acid dehydrogenase, Rv2996c, serA, serA1, type 1 D-3-phosphoglycerate dehydrogenase, type III 3-phosphoglycerate dehydrogenase, type IIIK PGDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.95 phosphoglycerate dehydrogenase

Reference

Reference on EC 1.1.1.95 - phosphoglycerate dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Uhr, M.L.; Sneddon, M.K.
Glycine and serine inhibition of D-glycerate dehydrogenase and 3-phosphoglycerate dehydrogenase of rat brain
FEBS Lett.
17
137-140
1971
Rattus norvegicus
Manually annotated by BRENDA team
Sugimoto, E.; Pizer, L.I.
The mechanism of end product inhibition of serine biosynthesis. I. purification and kinetics of phosphoglycerate dehydrogenase
J. Biol. Chem.
243
2081-2089
1968
Escherichia coli
Manually annotated by BRENDA team
Willis, J.E.; Sallach, H.J.
The occurence of D-3-phosphoglycerate dehydrogenase in animal tissues
Biochim. Biophys. Acta
81
39-54
1964
Bos taurus, Canis lupus familiaris, Gallus gallus, Oryctolagus cuniculus, Frog, Pigeon, Rattus norvegicus, Sus scrofa
-
Manually annotated by BRENDA team
Slaughter, J.C.; Davies, D.D.
3-Phosphoglycerate dehydrogenase from seedlings of Pisum sativum
Methods Enzymol.
41
278-281
1975
Pisum sativum
Manually annotated by BRENDA team
Feld, R.D.; Sallach, H.J.
D-3-Phosphoglycerate dehydrogenase from hog spinal cord-1
Methods Enzymol.
41
282-285
1975
Sus scrofa
Manually annotated by BRENDA team
Rosenblum, I.Y.; Sallach, H.J.
D-3-Phosphoglycerate dehydrogenase from wheat germ-1
Methods Enzymol.
41
285-289
1975
Triticum aestivum
Manually annotated by BRENDA team
Pizer, L.I.; Sugimoto, E.
3-Phosphoglycerate dehydrogenase (Escherichia coli)
Methods Enzymol.
17B
325-331
1971
Escherichia coli
-
Manually annotated by BRENDA team
Sojka, G.A.; Garner, H.R.
The serine biosynthetic pathway in Neurospora crassa
Biochim. Biophys. Acta
148
42-47
1967
Neurospora crassa
Manually annotated by BRENDA team
Umbarger, H.E.; Umbarger, M.A.
Biosynthetic pathway of serine in Salmonella typhimurium
Biochim. Biophys. Acta
62
193-195
1962
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Pizer, L.I.; Ponce-de-Leon, M.; Michalka, J.
Serine biosynthesis and regulation in Haemophilus influenzae
J. Bacteriol.
97
1357-1361
1969
Haemophilus influenzae
Manually annotated by BRENDA team
Winicov, I.
Stereospecificity of hydrogen transfer by phosphoglycerate dehydrogenase
Biochim. Biophys. Acta
397
288-293
1975
Escherichia coli
Manually annotated by BRENDA team
Slaughter, J.C.
Inhibition of 3-phosphoglycerate dehydrogenase from Pisum sativum by purine nucleotides
Biochem. J.
135
563-565
1973
Pisum sativum
Manually annotated by BRENDA team
Saski, R.; Pizer, L.I.
Regulatory properties of purified 3-phosphoglycerate dehydrogenase from Bacillus subtilis
Eur. J. Biochem.
51
415-427
1975
Bacillus subtilis
Manually annotated by BRENDA team
Tobey, K.L.; Grant, G.A.
The nucleotide sequence of the serA gene of Escherichia coli and the amino acid sequence of the encoded protein, D-3-phosphoglycerate dehydrogenase
J. Biol. Chem.
261
12179-12183
1986
Escherichia coli
Manually annotated by BRENDA team
Lund, K.; Merrill, D.K.; Guynn, R.W.
Purification and subunit structure of phosphoglycerate dehydrogenase from rabbit liver
Biochem. J.
238
919-922
1986
Oryctolagus cuniculus
Manually annotated by BRENDA team
Boland, M.J.; Schubert, K.R.
Phosphoglycerate dehydrogenase from soybean nodules
Plant Physiol.
71
658-661
1983
Glycine max
Manually annotated by BRENDA team
Anderson, B.M.; Dubler, R.E.
Inactivation of chicken liver D-3 phosphoglycerate dehydrogenase by N-alkylmaleimides
Arch. Biochem. Biophys.
200
583-589
1980
Gallus gallus
Manually annotated by BRENDA team
Slaughter, J.C.
The amino acid sequence of yeast phosphoglycerate mutase
Biochem. Soc. Trans.
3
1058-1061
1975
Pisum sativum
-
Manually annotated by BRENDA team
Grant, G.A.; Keefer, L.M.; Bradshaw, R.A.
D-3-Phosphoglycerate dehydrogenase from chicken liver. I. Purification
J. Biol. Chem.
253
2724-2726
1978
Gallus gallus
Manually annotated by BRENDA team
Grant, G.A.; Bradshaw, R.A.
D-3-phosphoglycerate dehydrogenase from chicken liver. II. Chemical and physical properties
J. Biol. Chem.
253
2727-2731
1978
Gallus gallus
Manually annotated by BRENDA team
Schuller, D.J.; Grant, G.A.; Banaszak, L.J.
The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase
Nat. Struct. Biol.
2
69-76
1995
Escherichia coli
Manually annotated by BRENDA team
Zhao, G.; Winkler, M.E.
A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12, and its possible implications for human 2-hydroxyglutaric aciduria
J. Bacteriol.
178
232-239
1996
Escherichia coli
Manually annotated by BRENDA team
Grant, G.A.; Schuller, D.J.; Banaszak, L.J.
A model for the regulation of D-3-phosphoglycerate dehydrogenase, a Vmax-type allosteric enzyme
Protein Sci.
5
34-41
1996
Escherichia coli
Manually annotated by BRENDA team
Al-Rabiee, R.; Zhang, Y.; Grant, G.A.
The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase
J. Biol. Chem.
271
23235-23238
1996
Escherichia coli
Manually annotated by BRENDA team
Ho, C.L.; Noji, M.; Saito, M.; Saito, K.
Regulation of serine biosynthesis in Arabidopsis
J. Biol. Chem.
274
397-402
1999
Arabidopsis thaliana
Manually annotated by BRENDA team
Grant, G.A.; Hu, Z.; Xu, X.L.
Amino acid residue mutations uncouple cooperative effects in Escherichia coli D-3-phosphoglycerate dehydrogenase
J. Biol. Chem.
276
17844-17850
2001
Escherichia coli
Manually annotated by BRENDA team
Grant, G.A.; Kim, S.J.; Xu, X.L.; Hu, Z.
The contribution of adjacent subunits to the active sites of D-3-phosphoglycerate dehydrogenase
J. Biol. Chem.
274
5357-5361
1999
Escherichia coli
Manually annotated by BRENDA team
Peters-Wendisch, P.; Netzer, R.; Eggeling, L.; Sahm, H.
3-Phosphoglycerate dehydrogenase from Corynebacterium glutamicum: the C-terminal domain is not essential for activity but is required for inhibition by L-serine
Appl. Microbiol. Biotechnol.
60
437-441
2002
Corynebacterium glutamicum
Manually annotated by BRENDA team
Konno, A.; Oota, Y.; Hashimoto, Y.; Kon, Y.; Iwanaga, T.
Localization of 3-phosphoglycerate dehydrogenase, an enzyme involved in de novo L-serine biosynthesis, in the peripheral nervous system and non-neuronal tissues of mice
Biomed. Res.
25
195-200
2004
Mus musculus
-
Manually annotated by BRENDA team
Ali, V.; Hashimoto, T.; Shigeta, Y.; Nozaki, T.
Molecular and biochemical characterization of D-phosphoglycerate dehydrogenase from Entamoeba histolytica. A unique enteric protozoan parasite that possesses both phosphorylated and nonphosphorylated serine metabolic pathways
Eur. J. Biochem.
271
2670-2681
2004
Entamoeba histolytica (Q76KF5), Entamoeba histolytica
Manually annotated by BRENDA team
Grant, G.A.; Hu, Z.; Xu, X.L.
Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding
J. Biol. Chem.
277
39548-39553
2002
Escherichia coli
Manually annotated by BRENDA team
Albers, E.; Laize, V.; Blomberg, A.; Hohmann, S.; Gustafsson, L.
Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae
J. Biol. Chem.
278
10264-10272
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Dey, S.; Hu, Z.; Xu, X.L.; Sacchettini, J.C.; Grant, G.A.
D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the E. coli and mammalian enzymes
J. Biol. Chem.
280
1484-14891
2005
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Dey, S.; Grant, G.A.; Sacchettini, J.C.
Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits
J. Biol. Chem.
280
14892-14899
2005
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Peters-Wendisch, P.; Stolz, M.; Etterich, H.; Kennerknecht, N.; Sahm, H.; Eggeling, L.
Metabolic engineering of Corynebacterium glutamicum for L-serine production
Appl. Environ. Microbiol.
71
7139-7144
2005
Corynebacterium glutamicum
Manually annotated by BRENDA team
Liberles, J.S.; Thorolfsson, M.; Martinez, A.
Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism
Amino Acids
28
1-12
2005
Escherichia coli (P0A9T0), Escherichia coli
Manually annotated by BRENDA team
Grant, G.A.; Hu, Z.; Xu, X.L.
Identification of amino acid residues contributing to the mechanism of cooperativity in Escherichia coli D-3-phosphoglycerate dehydrogenase
Biochemistry
44
16844-16852
2005
Escherichia coli (P0A9T0), Escherichia coli
Manually annotated by BRENDA team
Thompson, J.R.; Bell, J.K.; Bratt, J.; Grant, G.A.; Banaszak, L.J.
Vmax regulation through domain and subunit changes. The active form of phosphoglycerate dehydrogenase
Biochemistry
44
5763-5773
2005
Escherichia coli (P0A9T0), Escherichia coli
Manually annotated by BRENDA team
Ida, T.; Kugimiya, M.; Kogure, M.; Takahashi, R.; Tokuyama, T.
Phylogenetic relationships among ammonia-oxidizing bacteria as revealed by gene sequences of glyceraldehyde 3-phosphate dehydrogenase and phosphoglycerate kinase
J. Biosci. Bioeng.
99
569-576
2005
Escherichia coli K-12, Nitrosomonas sp., Nitrosolobus sp., Nitrosospira sp., Nitrosovibrio sp.
Manually annotated by BRENDA team
Shimizu, Y.; Sakuraba, H.; Doi, K.; Ohshima, T.
Molecular and functional characterization of D-3-phosphoglycerate dehydrogenase in the serine biosynthetic pathway of the hyperthermophilic archaeon Sulfolobus tokodaii
Arch. Biochem. Biophys.
470
120-128
2008
Sulfurisphaera tokodaii
Manually annotated by BRENDA team
Takasaki, C.; Miura, E.; Watanabe, M.
Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney
Biomed. Res.
28
61-69
2007
Mus musculus (Q61753), Mus musculus
Manually annotated by BRENDA team
Jun, d.o..Y.; Park, H.S.; Lee, J.Y.; Baek, J.Y.; Park, H.K.; Fukui, K.; Kim, Y.H.
Positive regulation of promoter activity of human 3-phosphoglycerate dehydrogenase (PHGDH) gene is mediated by transcription factors Sp1 and NF-Y
Gene
414
106-114
2008
Homo sapiens
Manually annotated by BRENDA team
Dey, S.; Hu, Z.; Xu, X.L.; Sacchettini, J.C.; Grant, G.A.
The effect of hinge mutations on effector binding and domain rotation in Escherichia coli D-3-phosphoglycerate dehydrogenase
J. Biol. Chem.
282
18418-18426
2007
Escherichia coli (P0A9T0), Escherichia coli
Manually annotated by BRENDA team
Burton, R.L.; Chen, S.; Xu, X.L.; Grant, G.A.
A novel mechanism for substrate inhibition in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase
J. Biol. Chem.
282
31517-31524
2007
Mycobacterium tuberculosis (P9WNX3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNX3)
Manually annotated by BRENDA team
Waditee, R.; Bhuiyan, N.H.; Hirata, E.; Hibino, T.; Tanaka, Y.; Shikata, M.; Takabe, T.
Metabolic engineering for betaine accumulation in microbes and plants
J. Biol. Chem.
282
34185-34193
2007
Aphanothece halophytica
Manually annotated by BRENDA team
Dey, S.; Burton, R.L.; Grant, G.A.; Sacchettini, J.C.
Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase
Biochemistry
47
8271-8282
2008
Mycobacterium tuberculosis (P9WNX3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNX3)
Manually annotated by BRENDA team
Burton, R.L.; Chen, S.; Xu, X.L.; Grant, G.A.
Role of the anion-binding site in catalysis and regulation of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase
Biochemistry
48
4808-4815
2009
Mycobacterium tuberculosis (P9WNX3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNX3)
Manually annotated by BRENDA team
Furuya, S.; Yoshida, K.; Kawakami, Y.; Yang, J.H.; Sayano, T.; Azuma, N.; Tanaka, H.; Kuhara, S.; Hirabayashi, Y.
Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency
Funct. Integr. Genomics
8
235-249
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Tabatabaie, L.; de Koning, T.J.; Geboers, A.J.; van den Berg, I.E.; Berger, R.; Klomp, L.W.
Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics
Hum. Mutat.
30
749-756
2009
Homo sapiens (O43175), Homo sapiens
Manually annotated by BRENDA team
Jeon, G.S.; Choi, D.H.; Lee, H.N.; Kim, D.W.; Chung, C.K.; Cho, S.S.
Expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase (Phgdh) and neutral amino acid transporter ASCT1 following an excitotoxic lesion in the mouse hippocampus
Neurochem. Res.
34
827-834
2009
Mus musculus
Manually annotated by BRENDA team
Kinoshita, M.O.; Shinoda, Y.; Sakai, K.; Hashikawa, T.; Watanabe, M.; Machida, T.; Hirabayashi, Y.; Furuya, S.
Selective upregulation of 3-phosphoglycerate dehydrogenase (Phgdh) expression in adult subventricular zone neurogenic niche
Neurosci. Lett.
453
21-26
2009
Mus musculus
Manually annotated by BRENDA team
Du, H.; Vitiello, D.; Sarno, J.; Taylor, H.
3-Phosphoglycerate dehydrogenase (3-PGDH) expression is regulated by HOXA10 in murine endometrium and human endometrial cells
Reproduction
139
237-245
2009
Homo sapiens (O43175), Homo sapiens, Mus musculus (Q61753), Mus musculus
Manually annotated by BRENDA team
Burton, R.L.; Chen, S.; Xu, X.L.; Grant, G.A.
Transient kinetic analysis of the interaction of L-serine with Escherichia coli D-3-phosphoglycerate dehydrogenase reveals the mechanism of V-type regulation and the order of effector binding
Biochemistry
48
12242-12251
2009
Escherichia coli (P0A9T0), Escherichia coli
Manually annotated by BRENDA team
Grant, G.A.
Transient kinetic analysis of L-serine interaction with Escherichia coli D-3-phosphoglycerate dehydrogenase containing amino acid mutations in the hinge regions
Biochemistry
50
2900-2906
2011
Escherichia coli
Manually annotated by BRENDA team
Mishra, V.; Kumar, A.; Ali, V.; Nozaki, T.; Zhang, K.Y.; Bhakuni, V.
Glu-108 is essential for subunit assembly and dimer stability of D-phosphoglycerate dehydrogenase from Entamoeba histolytica
Mol. Biochem. Parasitol.
181
117-124
2012
Entamoeba histolytica
Manually annotated by BRENDA team
Kumar, S.M.; Pampa, K.J.; Manjula, M.; Hemantha Kumar, G.; Kunishima, N.; Lokanath, N.K.
Crystal structures of type IIIH NAD-dependent D-3-phosphoglycerate dehydrogenase from two thermophiles
Biochem. Biophys. Res. Commun.
451
126-130
2014
Pyrococcus horikoshii (O58256), Pyrococcus horikoshii, Sulfurisphaera tokodaii (Q972A9), Sulfurisphaera tokodaii, Pyrococcus horikoshii DSM 12428 (O58256)
Manually annotated by BRENDA team
Fan, J.; Teng, X.; Liu, L.; Mattaini, K.R.; Looper, R.E.; Vander Heiden, M.G.; Rabinowitz, J.D.
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate
ACS Chem. Biol.
10
510-516
2015
Homo sapiens
Manually annotated by BRENDA team
Xu, G.; Jin, X.; Guo, W.; Dou, W.; Zhang, X.; Xu, Z.
Characterization, modification, and overexpression of 3-phosphoglycerate dehydrogenase in Corynebacterium glutamicum for enhancing L-serine production
Ann. Microbiol.
65
929-935
2015
Corynebacterium glutamicum (F2X354), Corynebacterium glutamicum SYPS-062 (F2X354)
Manually annotated by BRENDA team
Xu, X.L.; Chen, S.; Salinas, N.D.; Tolia, N.H.; Grant, G.A.
Comparison of type 1 D-3-phosphoglycerate dehydrogenases reveals unique regulation in pathogenic Mycobacteria
Arch. Biochem. Biophys.
570
32-39
2015
Bacillus subtilis, Corynebacterium glutamicum, Homo sapiens, Mycobacterium tuberculosis, Mycobacterium marinum, Mycolicibacterium smegmatis, Streptomyces coelicolor (Q9Z564)
Manually annotated by BRENDA team
Xu, X.L.; Grant, G.A.
Regulation of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase by phosphate-modulated quaternary structure dynamics and a potential role for polyphosphate in enzyme regulation
Biochemistry
53
4239-4249
2014
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Deng, H.; Chen, C.; Sun, C.; Wei, C.
Construction and characterization of Escherichia coli D-3-phosphoglycerate dehydrogenase mutants with feedback-inhibition relief
Chin. J. Biotechnol.
32
468-477
2016
Escherichia coli
Manually annotated by BRENDA team
Singh, R.K.; Raj, I.; Pujari, R.; Gourinath, S.
Crystal structures and kinetics of Type III 3-phosphoglycerate dehydrogenase reveal catalysis by lysine
FEBS J.
281
5498-5512
2014
Entamoeba histolytica (Q76KF5), Entamoeba histolytica
Manually annotated by BRENDA team
Mishra, V.; Kumar, A.; Ali, V.; Zhang, K.Y.; Nozaki, T.
Characterization of pH-induced transitions of Entamoeba histolytica D-phosphoglycerate dehydrogenase
Int. J. Biol. Macromol.
79
284-289
2015
Entamoeba histolytica
Manually annotated by BRENDA team
Ehmsen, J.T.; Ma, T.M.; Sason, H.; Rosenberg, D.; Ogo, T.; Furuya, S.; Snyder, S.H.; Wolosker, H.
D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase
J. Neurosci.
33
12464-12469
2013
Mus musculus
Manually annotated by BRENDA team
Deng, Y.; Wu, D.; Tachibana, H.; Cheng, X.
Molecular cloning and expression of phosphoglycerate dehydrogenase and phosphoserine aminotransferase in the serine biosynthetic pathway from Acanthamoeba castellanii
Parasitol. Res.
114
1387-1395
2015
Acanthamoeba castellanii (U3RH61), Acanthamoeba castellanii, Acanthamoeba castellanii ATCC 30011 (U3RH61)
Manually annotated by BRENDA team
Benstein, R.M.; Ludewig, K.; Wulfert, S.; Wittek, S.; Gigolashvili, T.; Frerigmann, H.; Gierth, M.; Fluegge, U.I.; Krueger, S.
Arabidopsis phosphoglycerate dehydrogenase1 of the phosphoserine pathway is essential for development and required for ammonium assimilation and tryptophan biosynthesis
Plant Cell
25
5011-5029
2013
Arabidopsis thaliana (O04130), Arabidopsis thaliana (O49485), Arabidopsis thaliana (Q9LT69), Arabidopsis thaliana
Manually annotated by BRENDA team
Toujani, W.; Munoz-Bertomeu, J.; Flores-Tornero, M.; Rosa-Tellez, S.; Anoman, A.D.; Alseekh, S.; Fernie, A.R.; Ros, R.
Functional characterization of the plastidial 3-phosphoglycerate dehydrogenase family in Arabidopsis
Plant Physiol.
163
1164-1178
2013
Arabidopsis thaliana (Q9LT69), Arabidopsis thaliana
Manually annotated by BRENDA team
Toujani, W.; Munoz-Bertomeu, J.; Flores-Tornero, M.; Rosa-Tellez, S.; Anoman, A.; Ros, R.
Identification of the phosphoglycerate dehydrogenase isoform EDA9 as the essential gene for embryo and male gametophyte development in Arabidopsis
Plant Signal. Behav.
8
e27207
2013
Arabidopsis thaliana (O49485)
Manually annotated by BRENDA team
Wang, Q.; Qi, Y.; Yin, N.; Lai, L.
Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenase
PLoS ONE
9
e94829
2014
Escherichia coli (P0A9T0), Escherichia coli
Manually annotated by BRENDA team
Xu, X.L.; Grant, G.A.
Determinants of substrate specificity in D-3-phosphoglycerate dehydrogenase. Conversion of the M. tuberculosis enzyme from one that does not use alpha-ketoglutarate as a substrate to one that does
Arch. Biochem. Biophys.
671
218-224
2019
Escherichia coli (P0A9T0), Escherichia coli, Mycobacterium tuberculosis (P9WNX3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNX3), Escherichia coli K12 (P0A9T0)
Manually annotated by BRENDA team
Yamamoto, K.; Mohri, S.; Furuya, S.
D-3-phosphoglycerate dehydrogenase from the silkworm Bombyx mori Identification, functional characterization, and expression
Arch. Insect Biochem. Physiol.
106
e21751
2021
Bombyx mori (H9JRZ9), Bombyx mori
Manually annotated by BRENDA team
Rohde, J.M.; Brimacombe, K.R.; Liu, L.; Pacold, M.E.; Yasgar, A.; Cheff, D.M.; Lee, T.D.; Rai, G.; Baljinnyam, B.; Li, Z.; Simeonov, A.; Hall, M.D.; Shen, M.; Sabatini, D.M.; Boxer, M.B.
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
Bioorg. Med. Chem.
26
1727-1739
2018
Homo sapiens (O43175), Homo sapiens
Manually annotated by BRENDA team
Grant, G.A.
D-3-Phosphoglycerate dehydrogenase
Front. Mol. Biosci.
5
110
2018
Escherichia coli (C3SVM7), Escherichia coli, Rattus norvegicus (O08651), Homo sapiens (O43175), Homo sapiens, Mycobacterium tuberculosis (P9WNX3), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WNX3)
Manually annotated by BRENDA team
Akashi, H.; Okamura, E.; Nishihama, R.; Kohchi, T.; Hirai, M.Y.
Identification and biochemical characterization of the serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase in Marchantia polymorpha
Front. Plant Sci.
9
956
2018
Marchantia polymorpha (A0A2R6X868), Marchantia polymorpha
Manually annotated by BRENDA team
Zhao, X.; Fu, J.; Du, J.; Xu, W.
The role of D-3-phosphoglycerate dehydrogenase in Cancer
Int. J. Biol. Sci.
16
1495-1506
2020
Homo sapiens (O43175), Homo sapiens
Manually annotated by BRENDA team
Yoshida, K.; Ohtaka, K.; Hirai, M.Y.; Hisabori, T.
Biochemical insight into redox regulation of plastidial 3-phosphoglycerate dehydrogenase from Arabidopsis thaliana
J. Biol. Chem.
295
14906-14915
2020
Arabidopsis thaliana (O04130), Arabidopsis thaliana (O49485), Arabidopsis thaliana (Q9LT69), Arabidopsis thaliana
Manually annotated by BRENDA team
Ravez, S.; Corbet, C.; Spillier, Q.; Dutu, A.; Robin, A.D.; Mullarky, E.; Cantley, L.C.; Feron, O.; Frederick, R.
alpha-Ketothioamide derivatives a promising tool to interrogate phosphoglycerate dehydrogenase (PHGDH)
J. Med. Chem.
60
1591-1597
2017
Homo sapiens (O43175)
Manually annotated by BRENDA team
Unterlass, J.E.; Wood, R.J.; Basle, A.; Tucker, J.; Cano, C.; Noble, M.M.E.; Curtin, N.J.
Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)
Oncotarget
8
104478-104491
2017
Homo sapiens (O43175), Homo sapiens
Manually annotated by BRENDA team
Spillier, Q.; Ravez, S.; Unterlass, J.; Corbet, C.; Degavre, C.; Feron, O.; Frederick, R.
Structure-activity relationships (SARs) of alpha-ketothioamides as inhibitors of phosphoglycerate dehydrogenase (PHGDH)
Pharmaceuticals
13
20
2020
Homo sapiens (O43175)
Manually annotated by BRENDA team
Zhang, W.; Zhang, M.; Gao, C.; Zhang, Y.; Ge, Y.; Guo, S.; Guo, X.; Zhou, Z.; Liu, Q.; Zhang, Y.; Ma, C.; Tao, F.; Xu, P.
Coupling between D-3-phosphoglycerate dehydrogenase and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis
Proc. Natl. Acad. Sci. USA
114
E7574-E7582
2017
Pseudomonas stutzeri (A4VGK3), Pseudomonas aeruginosa (Q9I6H5), Pseudomonas stutzeri A1501 (A4VGK3), Pseudomonas stutzeri A1501
Manually annotated by BRENDA team
Kito, K.; Tsutsumi, K.; Rai, V.; Theerawitaya, C.; Cha-Um, S.; Yamada-Kato, N.; Sakakibara, S.; Tanaka, Y.; Takabe, T.
Isolation and functional characterization of 3-phosphoglycerate dehydrogenase involved in salt responses in sugar beet
Protoplasma
254
2305-2313
2017
Beta vulgaris (A0A1Z4EAX3), Beta vulgaris (A0A1Z4EAX4)
Manually annotated by BRENDA team
Okamura, E.; Hirai, M.Y.
Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana
Sci. Rep.
7
3533
2017
Arabidopsis thaliana (O04130), Arabidopsis thaliana (O49485), Arabidopsis thaliana (Q9LT69), Arabidopsis thaliana
Manually annotated by BRENDA team