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EC 1.1.1.B57: 1-tetralone reductase [NADPH]

This is an abbreviated version!
For detailed information about 1-tetralone reductase [NADPH], go to the full flat file.

Wordmap for 1.1.1.B57

Word Map on EC 1.1.1.B57 Wordmap for 1.1.1.B57

Reaction

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1-tetralone
+
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NADPH
 +
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H+
=
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1-tetralol
 +
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NADP+

Synonyms

ADHII, MGG_02252, PAE2687, PyAeADHII, T4HNR, tetrahydroxynaphthalene reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                EC 1.1.1.B571.1.1.B57 1-tetralone reductase [NADPH]

Substrates Products

Substrates Products on EC 1.1.1.B57 - 1-tetralone reductase [NADPH]

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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
Reversibility
r=reversible
ir=irreversible
?=not specified
1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
(R)-scytalone + NADP+
show the reaction diagram
1,3,8-trihydroxynaphthalene + NADPH + H+
(R)-vermelone + NADP+
show the reaction diagram
1-tetralone + NADPH + H+
1-tetralol + NADP+
show the reaction diagram
2,3-dihydronaphthalene-1,4-dione + NADPH + H+
(S)-4-hydroxy-1-tetralone + NADP+
show the reaction diagram
Substrates: -
Products: -
?
2,3-epoxy-1,4-naphthoquinone + NADPH + H+
(1aS,7R,7aS)-7-hydroxy-7,7a-dihydronaphtho[2,3-b]oxiren-2(1aH)-one + NADP+
show the reaction diagram
Substrates: -
Products: -
?
2-hydroxy-1,4-naphthoquinone + 2 NADPH + H+
(3S,4R)-3,4-dihydroxy-1-tetralone + 2 NADP+
show the reaction diagram
2-hydroxy-1,4-naphthoquinone + NADPH + H+
cis-3,4-dihydroxy-1-tetralone + NADP+
show the reaction diagram
3,4-dihydro-1(2H)-naphthalenone + NADPH + H+
1,2,3,4-tetrahydronaphthalen-1-ol + NADP+
show the reaction diagram
5-hydroxy-2,3-dihydronaphthalene-1,4-dione + NADPH + H+
(S)-4,8-dihydroxy-1-tetralone + NADP+
show the reaction diagram
Substrates: -
Products: -
?
flaviolin + NADPH + H+
cis-(3S,4R)-4-hydroxyscytalone + NADP+
show the reaction diagram
additional information
?
-
Substrates: NADPH-dependent enzymatic reduction of 2-hydroxynaphthoquinones, resulting in 3,4-dihydroxy-1-tetralones, proceeds via the stable 1,4-diketo tautomer of the hydronaphthoquinones. No activity with 1,2,4-trihydroxynaphthalene. Hydronaphthoquinone tautomers play an unprecedented and essential role in the biosynthesis of many natural products and are involved in breaking the redox cycle of quinones-hydroquinones. Menadione epoxide is a poor substrate
Products: -
?