1.1.2.3: L-lactate dehydrogenase (cytochrome)

This is an abbreviated version!
For detailed information about L-lactate dehydrogenase (cytochrome), go to the full flat file.

Word Map on EC 1.1.2.3

Reaction

(S)-lactate
+ 2 ferricytochrome c =
pyruvate
+ 2 ferrocytochrome c + 2 H+

Synonyms

Cyb2, cytochrome b2, cytochrome c oxido reductase, FC b2, Fcb2, flavocytochrome b, flavocytochrome b2, iLDH, L(+)-lactate:cytochrome c oxidoreductase, L-(+)-lactate ferricytochrome c oxidoreductase, L-lactate cytochrome c oxidoreductase, L-lactate cytochrome c reductase, L-lactate dehydrogenase [Cytochrome], L-lactate ferricytochrome C oxidoreductase, L-lactate-cytochrome c oxidoreductase, L-lactate-cytochrome c-oxidoreductase, L-lactate: cytochrome c oxidoreductase, L-lactate:cytochrome c oxidoreductase, L-lactate:cytochrome c-oxidoreductase, L-LCR, L-LDH (FMN-dependent), lactate dehydrogenase (cytochrome), lactic acid dehydrogenase, lactic cytochrome c reductase, NAD+ - independent LDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.2 With a cytochrome as acceptor
                1.1.2.3 L-lactate dehydrogenase (cytochrome)

Cloned

Cloned on EC 1.1.2.3 - L-lactate dehydrogenase (cytochrome)

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CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
cytochrome domain in Escherichia coli
-
expressed in Saccharomyces cerevisiae YN1 strain (flavocytochrome b2 deletion mutant of strain XS560-1)
-
expression of flavocytochrome b2 flavin-binding domain in Escherichia coli
-
flavin and heme domain expressed in Escherichia coli
-
gene CYB2, expression in the recipient strain Hansenula polymorpha C-105 impaired in glucose repression and devoid of catalase activity, under the control of the strong Hansenula polymorpha alcohol oxidase promoter in a plasmid for multicopy integration, optimization of culture conditions for recombinant cells with increased FCb2 activity
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in Escherichia coli
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in Escherichia coli AR120
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in Escherichia coli JM 101
in Escherichia coli MM294
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in Escherichia coli TG1
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N-terminally YFP-tagged enzyme expression and coexpression with a cyan fluorescent protein (CFP) fusion of PTS1, known to mediate localization to peroxisomes, in Nicotiana benthamiana leaves. GOX3 can rescue the cyb2 lethal phenotype in Saccharomyces cerevisiae
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overexpression in Hansenula polymorpha leading to enhanced L-lactate-dependent respiration compared to the wild-type cells
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recombinant overexpression of the enzyme in Hansenula polymorpha yeast cells additionally enriched by recombinant enzyme bound with gold nanoparticles , FC b2-nAu
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recombinant wild-type Fcb2 and its recombinant FDH domain (FMN-binding domain) are expressed in Escherichia coli
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recombinant wild-type Fcb2 and its recombinant flavin domain are expressed in Escherichia coli
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recombinant wild-type Fcb2 and its recombinant FMN-binding domain (FDH domain) are expressed in Escherichia coli
-