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1.1.2.3: L-lactate dehydrogenase (cytochrome)

This is an abbreviated version!
For detailed information about L-lactate dehydrogenase (cytochrome), go to the full flat file.

Word Map on EC 1.1.2.3

Reaction

(S)-lactate
+
2 ferricytochrome c
=
pyruvate
+ 2 ferrocytochrome c + 2 H+

Synonyms

Cyb2, Cyb2A, cytochrome b2, cytochrome c oxido reductase, FC b2, Fcb2, flavocytochrome b, flavocytochrome b2, iLDH, L(+)-lactate:cytochrome c oxidoreductase, L-(+)-lactate ferricytochrome c oxidoreductase, L-lactate cytochrome c oxidoreductase, L-lactate cytochrome c reductase, L-lactate dehydrogenase [Cytochrome], L-lactate ferricytochrome C oxidoreductase, L-lactate-cytochrome c oxidoreductase, L-lactate-cytochrome c-oxidoreductase, L-lactate: cytochrome c oxidoreductase, L-lactate:cytochrom c oxidoreductase, L-lactate:cytochrome c oxidoreductase, L-lactate:cytochrome c-oxidoreductase, L-LCO, L-LCR, L-LDH (FMN-dependent), lactate dehydrogenase (cytochrome), lactic acid dehydrogenase, lactic cytochrome c reductase, lldA, LldD, NAD+ - independent LDH, PA4771

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.2 With a cytochrome as acceptor
                1.1.2.3 L-lactate dehydrogenase (cytochrome)

Substrates Products

Substrates Products on EC 1.1.2.3 - L-lactate dehydrogenase (cytochrome)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-2-hydroxybutyrate + ferricytochrome c
2-oxobutyrate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
(S)-2-hydroxyhexanoate + ferricytochrome c
2-oxohexanoate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
(S)-2-hydroxyoctanoate + ferricytochrome c
2-oxooctanoate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
(S)-2-hydroxyvalerate + ferricytochrome c
2-oxovalerate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
(S)-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c + 2 H+
show the reaction diagram
(S)-lactate + 2 flavocytochrome b2
pyruvate + 2 ferrocytochrome c + 2 H+
show the reaction diagram
(S)-lactate + 2 potassium ferricyanide
pyruvate + 2 reduced potassium ferricyanide + 2 H+
show the reaction diagram
-
-
-
-
?
(S)-lactate + cytochrome c
pyruvate + oxidized cytochrome c
show the reaction diagram
(S)-lactate + K3[Fe(CN)6]
?
show the reaction diagram
(S)-lactate + potassium ferricyanide
pyruvate + potassium ferrocyanide
show the reaction diagram
-
-
-
-
?
(S)-mandelate + ferricytochrome c
hydroxy(phenyl)acetate + ferrocytochrome c
show the reaction diagram
(S)-phenyllactate + ferricytochrome c
phenylpyruvate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
fluoropyruvate + ferrocytochrome c + H+
?
show the reaction diagram
-
-
-
-
?
glycolate + ferricytochrome c
glyoxylate + ferrocytochrome c
show the reaction diagram
-
very poor substrate
-
-
?
L-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c + 2 H+
show the reaction diagram
-
-
-
?
L-lactate + ferricyanide
pyruvate + ferrocyanide + H+
show the reaction diagram
L-lactate + ferricytochrome c
pyruvate + ferrocytochrome c + H+
show the reaction diagram
L-lactate + O2
? + superoxide anion
show the reaction diagram
the FDH domain reacts slowly with oxygen with formation of superoxide anion when separated from its natural electron acceptor, whether isolated or included in the holoenzyme
-
-
?
L-lactate + potassium ferricyanide
pyruvate + potassium ferrocyanide + H+
show the reaction diagram
phenyllactate + ferricytochrome c
phenylpyruvate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
pyruvate + 2 ferrocytochrome c + 2 H+
(S)-lactate + 2 ferricytochrome c
show the reaction diagram
-
-
-
-
?
additional information
?
-