1.1.2.3: L-lactate dehydrogenase (cytochrome)

This is an abbreviated version!
For detailed information about L-lactate dehydrogenase (cytochrome), go to the full flat file.

Word Map on EC 1.1.2.3

Reaction

(S)-lactate
+ 2 ferricytochrome c =
pyruvate
+ 2 ferrocytochrome c + 2 H+

Synonyms

Cyb2, cytochrome b2, cytochrome c oxido reductase, FC b2, Fcb2, flavocytochrome b, flavocytochrome b2, iLDH, L(+)-lactate:cytochrome c oxidoreductase, L-(+)-lactate ferricytochrome c oxidoreductase, L-lactate cytochrome c oxidoreductase, L-lactate cytochrome c reductase, L-lactate dehydrogenase [Cytochrome], L-lactate ferricytochrome C oxidoreductase, L-lactate-cytochrome c oxidoreductase, L-lactate-cytochrome c-oxidoreductase, L-lactate: cytochrome c oxidoreductase, L-lactate:cytochrome c oxidoreductase, L-lactate:cytochrome c-oxidoreductase, L-LCR, L-LDH (FMN-dependent), lactate dehydrogenase (cytochrome), lactic acid dehydrogenase, lactic cytochrome c reductase, NAD+ - independent LDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.2 With a cytochrome as acceptor
                1.1.2.3 L-lactate dehydrogenase (cytochrome)

Substrates Products

Substrates Products on EC 1.1.2.3 - L-lactate dehydrogenase (cytochrome)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-2-hydroxybutyrate + ferricytochrome c
2-oxobutyrate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
(S)-2-hydroxyhexanoate + ferricytochrome c
2-oxohexanoate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
(S)-2-hydroxyoctanoate + ferricytochrome c
2-oxooctanoate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
(S)-2-hydroxyvalerate + ferricytochrome c
2-oxovalerate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
(S)-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c + 2 H+
show the reaction diagram
(S)-lactate + 2 flavocytochrome b2
pyruvate + 2 ferrocytochrome c + 2 H+
show the reaction diagram
(S)-lactate + 2 potassium ferricyanide
pyruvate + 2 reduced potassium ferricyanide + 2 H+
show the reaction diagram
-
-
-
-
?
(S)-lactate + cytochrome c
pyruvate + oxidized cytochrome c
show the reaction diagram
(S)-lactate + K3[Fe(CN)6]
?
show the reaction diagram
(S)-lactate + potassium ferricyanide
pyruvate + potassium ferrocyanide
show the reaction diagram
-
-
-
-
?
(S)-mandelate + ferricytochrome c
hydroxy(phenyl)acetate + ferrocytochrome c
show the reaction diagram
(S)-phenyllactate + ferricytochrome c
phenylpyruvate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
glycolate + ferricytochrome c
glyoxylate + ferrocytochrome c
show the reaction diagram
-
very poor substrate
-
-
?
L-lactate + ferricyanide
pyruvate + ferrocyanide + H+
show the reaction diagram
L-lactate + ferricytochrome c
pyruvate + ferrocytochrome c + H+
show the reaction diagram
L-lactate + O2
? + superoxide anion
show the reaction diagram
-
the FDH domain reacts slowly with oxygen with formation of superoxide anion when separated from its natural electron acceptor, whether isolated or included in the holoenzyme
-
-
?
L-lactate + potassium ferricyanide
pyruvate + potassium ferrocyanide + H+
show the reaction diagram
phenyllactate + ferricytochrome c
phenylpyruvate + ferrocytochrome c
show the reaction diagram
-
-
-
-
?
pyruvate + 2 ferrocytochrome c + 2 H+
(S)-lactate + 2 ferricytochrome c
show the reaction diagram
-
-
-
-
?
additional information
?
-