1.1.3.2: L-lactate oxidase
This is an abbreviated version!
For detailed information about L-lactate oxidase, go to the full flat file.
Reaction
Synonyms
AvLOX, L-lactate oxidase, LctO, LOX
ECTree
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Cofactor
Cofactor on EC 1.1.3.2 - L-lactate oxidase
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FMN
flavin reduction is a direct measure of alpha-C-H bond breakage
FMN
FMN is positioned deep down in the funnel-shaped substrate-binding site, behind (or underneath) the substrate when it is bound. Residues Tyr40, Pro93, Gln144, Tyr146, Thr172, Lys241, Asp296, Arg300 and Arg320 are involved in binding
FMN
removal of FMN and reconstitution of the apoprotein with 12 FMN derivatives with various substituents at the flavin 6- and 8-positions show an increase in the reduction rate constant with increasing redox potential, except that, with lactate, a limiting rate constant is obtained with flavins of high potential
FMN
The standard redox potentials of enzyme-FMN/enzyme-FMNH and enzyme-FMNH/enzyme-FMNH2 are -95 mV and -161 mV, respectively, at pH 7.0, 25°C in 0.01 M imidazol buffer