1.1.3.2: L-lactate oxidase

This is an abbreviated version!
For detailed information about L-lactate oxidase, go to the full flat file.

Reaction

Synonyms

AvLOX, L-lactate oxidase, LctO, LOX

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.3 With oxygen as acceptor

                1.1.3.2 L-lactate oxidase

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Results	in table
1	Activating Compound
7	AA Sequence
14	Application
4	Cloned(Commentary)
8	Cofactor
8	Crystallization (Commentary)
3	Expression
3	General Information
21	Inhibitors
3	kcat/KM [mM/s]
7	Ki Value [mM]
36	KM Value [mM]
3	Localization
6	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
55	Organism
14	PDB ID
3	pH Optimum
1	pH Stability
24	Protein Variants
6	Purification (Commentary)
1	Reaction
47	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
73	Substrates and Products (Substrate)
18	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
23	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.1.3.2 - L-lactate oxidase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(R)-lactate

2 entries

alpha-hydroxybutanoate

Aerococcus viridans

D4YFM2

-

745455

Bromopyruvate

Aerococcus viridans

Q44467

irreversible inactivation

744203

Cibacron blue 3GA

Aerococcus viridans

D4YFM2

at low concentrations, Cibacron Blue 3GA behaves as a dye-, pH- and time-dependent inhibitor, non-linear inhibition

745455

D-lactate

Aerococcus viridans

Q44467

competitive

744203

DL-2-Hydroxybutanoate

Aerococcus viridans

Q44467

competitive

744203

FeSO4

Gram-negative soil bacterium

-

86% inhibition at 1 mM

440395

glycolate

2 entries

HgCl2

Gram-negative soil bacterium

-

28% inhibition at 1 mM

440395

iodoacetate

Gram-negative soil bacterium

-

33% inhibition at 1 mM

440395

L-leucine

Gram-negative soil bacterium

-

29% inhibition at 1 mM

440395

L-phenylalanine

Gram-negative soil bacterium

-

28% inhibition at 1 mM

440395

Lactate

2 entries

MnSO4

Gram-negative soil bacterium

-

47% inhibition at 1 mM

440395

NAD+

Rattus norvegicus

-

competitive

744894

oxalate

Aerococcus viridans

Q44467

competitive

744203

p-chloromercuribenzoate

Gram-negative soil bacterium

-

21% inhibition at 1 mM

440395

ZnSO4

Gram-negative soil bacterium

-

28% inhibition at 1 mM

440395

(R)-lactate

Aerococcus viridans

D4YFM2

-

745455

(R)-lactate

Gram-negative soil bacterium

-

at concentrations higher than 10 mM

440395

glycolate

Aerococcus viridans

Q44467

competitive

744203

glycolate

Aerococcus viridans

D4YFM2

-

745455

Lactate

Gram-negative soil bacterium

-

at concentrations higher than 20 mM

440395

Lactate

Streptococcus iniae

A9QH69

growth rates of Streptococcus iniae expressing the type 2 enzyme are not reduced at lactate concentrations of 0.3% and 0.5%, whereas a strain expressing the type 1 enzyme exhibits reduced growth rates at these lactate concentrations

744092