1.1.5.12: D-lactate dehydrogenase (quinone)

This is an abbreviated version, for detailed information about D-lactate dehydrogenase (quinone), go to the full flat file.

Reaction

(R)-lactate
+
a quinone
=
pyruvate
+
a quinol

Synonyms

Cg1027, DLD, quinone-dependent D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.12 D-lactate dehydrogenase (quinone)

Substrates Products

Substrates Products on EC 1.1.5.12 - D-lactate dehydrogenase (quinone)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-lactate + 3-(4,5-dimethylthiazolyI-2)-2,5-diphenyltetrazolium bromidephenazine methosulfate
pyruvate + reduced 3-(4,5-dimethylthiazolyI-2)-2,5-diphenyltetrazolium bromidephenazine methosulfate
show the reaction diagram
-
-
-
-
?
(R)-lactate + 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide-phenazine methosulfate
pyruvate + reduced 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide-phenazine methosulfate
show the reaction diagram
(R)-lactate + a quinone
pyruvate + a quinol
show the reaction diagram
-
-
-
-
?
(R,S)-2-hydroxybutanoate + a quinone
2-oxobutanoate + a quinol
show the reaction diagram
-
12% of the activity with (R)-lactate
-
-
?
(S)-lactate + dichlorophenolindolphenol
pyruvate + reduced dichlorophenolindolphenol
show the reaction diagram
-
14% of the activity with (R)-lactate
-
-
?
D-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
show the reaction diagram
D-lactate + ferricyanide
pyruvate + ferrocyanide
show the reaction diagram
D-lactate + ubiquinone 1
pyruvate + reduced ubiquinone 1
show the reaction diagram
D-lactate + [3, (4,5-dimethylthiazolyl-2-)-2,5]diphenyl tetrazolium
pyruvate + reduced 2,6-dichloroindophenol
show the reaction diagram
DL-2-hydroxybutanoate + 2,6-dichloroindophenol
2-oxobutanoate + reduced 2,6-dichloroindophenol
show the reaction diagram
L-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
show the reaction diagram
additional information
?
-