1.1.5.12: D-lactate dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about D-lactate dehydrogenase (quinone), go to the full flat file.
Reaction
Synonyms
Cg1027, D-iLDH, DLD, Dld2, Fe-S D-iLDH, lldE, NAD-independent D-lactate dehydrogenase, pp4737, quinone-dependent D-lactate dehydrogenase
ECTree
1.1.5.12 D-lactate dehydrogenase (quinone)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.5.12 - D-lactate dehydrogenase (quinone)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c
quinone is the preferred electron acceptor of the enzyme
-
-
?
(R)-lactate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
pyruvate + ?
quinone is the preferred electron acceptor of the enzyme
-
-
?
(R)-lactate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
-
-
-
?
(R)-lactate + cytochrome c
pyruvate + reduced cytochrome c
-
-
-
?
(R)-lactate + phenazine methosulfate
pyruvate + reduced phenazine methosulfate
-
-
-
-
?
(R,S)-2-hydroxybutanoate + a quinone
2-oxobutanoate + a quinol
-
12% of the activity with (R)-lactate
-
-
?
(S)-lactate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
pyruvate + ?
quinone is the preferred electron acceptor of the enzyme
-
-
?
(S)-lactate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
poor substrate
-
-
?
(S)-lactate + oxidized dichlorophenolindophenol
pyruvate + reduced dichlorophenolindophenol
-
14% of the activity with (R)-lactate
-
-
?
D-2-hydroxybutanoate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
2-oxobutanoate + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
-
-
-
?
D-2-hydroxybutyrate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
2-oxobutanoate + ?
-
-
-
?
D-2-hydroxybutyrate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
? + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
-
-
-
?
D-glycerate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
?
-
-
-
?
D-glycerate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
? + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
-
-
-
?
D-glycerate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
D-glyceraldehyde + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
poor substrate
-
-
?
D-lactate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
-
-
-
?
D-lactate + oxidized 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium
DL-2-hydroxybutanoate + 2,6-dichloroindophenol
2-oxobutanoate + reduced 2,6-dichloroindophenol
L-lactate + 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
pyruvate + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
-
-
-
?
(R)-lactate + coenzyme Q10
pyruvate + reduced coenzyme Q10
quinone is the preferred electron acceptor of the enzyme
-
-
?
(R)-lactate + coenzyme Q10
pyruvate + reduced coenzyme Q10
-
-
-
?
(R)-lactate + oxidized phenazine methosulfate
pyruvate + reduced phenazine methosulfate
-
-
-
-
?
(R)-lactate + oxidized phenazine methosulfate
pyruvate + reduced phenazine methosulfate
-
-
-
-
?
D-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
-
-
-
?
D-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
-
-
-
?
D-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
-
-
-
?
D-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
-
-
-
?
D-lactate + oxidized 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium
-
-
-
-
?
D-lactate + oxidized 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium
pyruvate + reduced 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium
-
-
-
-
?
DL-2-hydroxybutanoate + 2,6-dichloroindophenol
2-oxobutanoate + reduced 2,6-dichloroindophenol
-
about 5% of the activity with D-lactate
-
-
?
DL-2-hydroxybutanoate + 2,6-dichloroindophenol
2-oxobutanoate + reduced 2,6-dichloroindophenol
-
about 5% of the activity with D-lactate
-
-
?
L-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
about 5% of the activity with D-lactate
-
-
?
L-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
about 5% of the activity with D-lactate
-
-
?
L-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
-
-
-
?
L-lactate + 2,6-dichloroindophenol
pyruvate + reduced 2,6-dichloroindophenol
-
-
-
-
?
additional information
?
-
-
no significant reaction with D-malate, L-malate, D-tartrate and L-tartrate
-
-
?
additional information
?
-
-
no significant reaction with D-malate, L-malate, D-tartrate and L-tartrate
-
-
?
additional information
?
-
-
not active with D-glycerate, L-glycerate, succinate, malate, D-tartrate, L-tartrate, meso-tartrate, 1-propanol, or isopropanol as substrates and oxidized diphosphopyridine nucleotide has no effect on the catalytic conversion of D-lactate to pyruvate
-
-
?
additional information
?
-
-
not active with D-glycerate, L-glycerate, succinate, malate, D-tartrate, L-tartrate, meso-tartrate, 1-propanol, or isopropanol as substrates and oxidized diphosphopyridine nucleotide has no effect on the catalytic conversion of D-lactate to pyruvate
-
-
?
additional information
?
-
the enzyme exhibits narrow substrate specificity. No activity with D-2-hydroxybutyrate, L-2-hydroxybutyrate, D-mandelate, L-mandelate, D-3-phenyllactate, D-glycerate, L-glycerate, DL-2-hydroxyisocaproate, and DL-2-hydroxyoctanoate, with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide as an electron acceptor
-
-
-
additional information
?
-
quinone is the preferred electron acceptor of the enzyme. No substrates: glycolate, L-2-hydroxybutyrate, D-mandelate, L-mandelate, D-3-phenyllactate, L-glycerate, DL-2-hydroxyisocaproate, and DL-2-hydroxyoctanoate
-
-
-
