Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.5.3: glycerol-3-phosphate dehydrogenase

This is an abbreviated version!
For detailed information about glycerol-3-phosphate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.5.3

Reaction

sn-glycerol 3-phosphate
+
a quinone
=
glycerone phosphate
+
a quinol

Synonyms

DsFAD-GPDH, EC 1.1.2.1, EC 1.1.99.5, FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-G3PDH, FAD-glycerol phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol-3-phosphate dehydrogenase, flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenase, flavin-linked glycerol-3-phosphate ubiquinone oxidoreductase, flavoprotein-dependent glycerol-3-phosphate dehydrogenase, G3PD, GDP, GLPD, GlpO, glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerol-3-phosphate dehydrogenase 2, glycerol-3-phosphate oxidoreductase, glycerophosphate dehydrogenase, GmGPDH12, GPD1, GPD2, GPDH, mGPDH, mitochondrial glycerol-3-phosphate dehydrogenase, mitochondrial sn-glycerol 3-phosphate dehydrogenase, mtG3PDH, putG3PDH, SDP6, sn-glycerol 3-phosphate dehydrogenase, sn-glycerol-3-phosphate dehydrogenase, ZmGPDH6

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.3 glycerol-3-phosphate dehydrogenase

Systematic Name

Systematic Name on EC 1.1.5.3 - glycerol-3-phosphate dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SYSTEMATIC NAME
IUBMB Comments
sn-glycerol 3-phosphate:quinone oxidoreductase
This flavin-dependent dehydrogenase is an essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis. In bacteria, the enzyme is localized to the cytoplasmic membrane [6], while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane [2]. In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8, glycerol-3-phosphate dehydrogenase (NAD+), forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD+ by the mitochondrial electron-transport chain [3]. This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix [7,8]. Insect flight muscle uses only CoQ10 as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ9 [4]. The enzyme is activated by calcium [3].