1.1.98.4: F420H2:quinone oxidoreductase
This is an abbreviated version!
For detailed information about F420H2:quinone oxidoreductase, go to the full flat file.
Word Map on EC 1.1.98.4
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1.1.98.4
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heterodisulfide
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methanosarcina
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methanogen
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methanophenazine
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methanogenesis
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archaeon
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methane
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f420h2-dependent
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ferredoxin
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mazei
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2-hydroxyphenazine
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phenazines
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atmosphere
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subcomplexes
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viologen
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methanotrophic
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metronidazole
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nadh-dependent
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hdrabc
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greenhouse
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h2-dependent
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electron-transporting
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thermophila
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eukarya
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cob-s-s-com
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hydrogenases
- 1.1.98.4
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heterodisulfide
- methanosarcina
-
methanogen
- methanophenazine
-
methanogenesis
- archaeon
- methane
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f420h2-dependent
- ferredoxin
- mazei
- 2-hydroxyphenazine
- phenazines
- atmosphere
-
subcomplexes
- viologen
-
methanotrophic
- metronidazole
-
nadh-dependent
- hdrabc
-
greenhouse
-
h2-dependent
-
electron-transporting
- thermophila
- eukarya
- cob-s-s-com
- hydrogenases
Reaction
Synonyms
AF1833, F420H2 dehydrogenase, F420H2:quinone oxidoreductase complex, FqoF protein
ECTree
1.1.98.4 F420H2:quinone oxidoreductaseAdvanced search results
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Natural Substrates Products
Natural Substrates Products on EC 1.1.98.4 - F420H2:quinone oxidoreductase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
menaquinone + reduced coenzyme F420
menaquinol + oxidized coenzyme F420
the FqoF protein forms the input device of the protein complex which oxidizes coenzyme F420H2. Thus, this polypeptide replaces the NADH-oxidizing module of NADH dehydrogenases of bacteria which are not found in Archaeoglobus fulgidus. Then the electrons are channeled to the membrane-associated fragment composed of FqoBCDI, which is homologous to the corresponding module of complex I. As the subunits FqoAHJKLMN are highly hydrophobic and are related to polypeptides comprising the membrane fragment of complex I, they may form the membrane-integral module of the F420H2:quinone oxidoreductase that is responsible for the reduction of a special menaquinone found in the cytoplasmic membrane of Archaeoglobus fulgidus
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?
menaquinone + reduced coenzyme F420
menaquinol + oxidized coenzyme F420
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the physiological electron acceptor of the enzyme complex is most likely the menaquinone found in the membrane fraction of Archaeoglobus fulgidus. The reduction of menaquinone by F420H2 in Archaeoglobus fulgidus is catalyzed by a membrane-bound complex composed of at least seven different subunits. It contains 1-2 mol FAD and8 mol Fe-S/mol complex. The complex subunit composition indicates that the F420H2:quinone oxidoreductase complex from Archaeoglobus fulgidus is functionally analogous to the NADH:quinone oxidoreductase complex from mitochondria and bacteria
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?
additional information
?
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the enzyme is involved in the reduction of heterodisulfide
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?
additional information
?
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the enzyme is involved in the reduction of heterodisulfide
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?
