1.1.98.6: ribonucleoside-triphosphate reductase (formate)
This is an abbreviated version!
For detailed information about ribonucleoside-triphosphate reductase (formate), go to the full flat file.
Word Map on EC 1.1.98.6
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1.1.98.6
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glycyl
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s-adenosylmethionine
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formate-lyase
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deoxyribonucleotides
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oxygen-sensitive
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flavodoxins
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adomet
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2,3-aminomutase
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coproporphyrinogen
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radical-based
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thiyl
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homolytic
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benzylsuccinate
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datp-sepharose
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medicine
- 1.1.98.6
-
glycyl
- s-adenosylmethionine
- formate-lyase
- deoxyribonucleotides
-
oxygen-sensitive
- flavodoxins
- adomet
-
2,3-aminomutase
- coproporphyrinogen
-
radical-based
-
thiyl
-
homolytic
- benzylsuccinate
-
datp-sepharose
- medicine
Reaction
Synonyms
anaerobic ribonucleoside-triphosphate reductase, anaerobic ribonucleotide reductase, class III ribonucleoside-triphosphate reductase, nrdD
ECTree
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Crystallization
Crystallization on EC 1.1.98.6 - ribonucleoside-triphosphate reductase (formate)
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quantum chemical calculation of reaction mechanism. Carbon dioxide is formed from formate, which is present as a cofactor. The formate first forms a formyl radical. The next step, where the formyl radical protonates the 3'-keto group of the substrate, is rate limiting with a calculated total barrier of 19.9 kcal/mol, in reasonable agreement with the experimental rate-limiting barrier of 17 kcal/mol. Zero-point and entropy effects are quite significant in lowering the barrier
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