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1.1.99.2: L-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about L-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.99.2

Reaction

(S)-2-hydroxyglutarate
+
acceptor
=
2-oxoglutarate
+
reduced acceptor

Synonyms

2-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate dehydrogenase (NAD+ specific), alpha-hydroxyglutarate oxidoreductase, alpha-ketoglutarate reductase, dehydrogenase, 2-hydroxyglutarate, hydroxyglutaric dehydrogenase, L-2-HG dehydrogenase, L-2-HGDH, L-2-hydroxyglutarate dehydrogenase, L-2-hydroxyglutaric acid dehydrogenase, L-2HG dehydrogenase, L-2HGDH, L-alpha-hydroxyglutarate dehydrogenase, L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase, L2HGDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.2 L-2-hydroxyglutarate dehydrogenase

Engineering

Engineering on EC 1.1.99.2 - L-2-hydroxyglutarate dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A140P
-
the mutation is associated with L-2-hydroxyglutaric aciduria
A184V
-
the mutation is associated with L-2-hydroxyglutaric aciduria
A406V
-
the mutation is associated with L-2-hydroxyglutaric aciduria
A62D
-
the mutation is associated with L-2-hydroxyglutaric aciduria
C179R
-
the mutation is associated with L-2-hydroxyglutaric aciduria
DELTA-exon9
-
mutated protein is inactive and abnormally processed
E176D
E176G
-
the mutation is associated with L-2-hydroxyglutaric aciduria
E268X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
E336K
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G116D
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G128X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G156V
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G211D
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G211V
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G260A
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G260V
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G55D
-
the mutation is associated with L-2-hydroxyglutaric aciduria
G57R
-
the mutation is associated with L-2-hydroxyglutaric aciduria
H434P
-
the mutation is associated with L-2-hydroxyglutaric aciduria
H98R
-
the mutation is associated with L-2-hydroxyglutaric aciduria
H98Y
-
the mutation is associated with L-2-hydroxyglutaric aciduria
K246N
-
the mutation is associated with L-2-hydroxyglutaric aciduria
P302L
-
the mutation is associated with L-2-hydroxyglutaric aciduria
P441E
-
the mutation is associated with L-2-hydroxyglutaric aciduria
Q197X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
Q204X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
R251X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
R277X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
R282Q
-
the mutation is associated with L-2-hydroxyglutaric aciduria
R282W
-
the mutation is associated with L-2-hydroxyglutaric aciduria
R335X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
R70X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
S263L
-
the mutation is associated with L-2-hydroxyglutaric aciduria
S263X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
S440Y
-
the mutation is associated with L-2-hydroxyglutaric aciduria
V296E
-
the mutation is associated with L-2-hydroxyglutaric aciduria
Y153X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
Y195C
-
the mutation is associated with L-2-hydroxyglutaric aciduria
Y301X
-
the mutation is associated with L-2-hydroxyglutaric aciduria
Y367C
-
the mutation is associated with L-2-hydroxyglutaric aciduria
additional information