1.1.99.24: hydroxyacid-oxoacid transhydrogenase

This is an abbreviated version!
For detailed information about hydroxyacid-oxoacid transhydrogenase, go to the full flat file.

Reaction

Synonyms

ADHFE1, alcohol dehydrogenase iron containing 1, HOT, hydroxyacid-oxoacid transhydrogenase, iron-dependent alcohol dehydrogenase ADHFe1, transhydrogenase, hydroxy acid-oxo acid

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.24 hydroxyacid-oxoacid transhydrogenase

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Results

in table

1

Activating Compound

3740

AA Sequence

1

Application

1

CAS Registry Number

1

Cloned(Commentary)

6

Cofactor

65

Disease/ Diagnostics

1

Expression

2

General Information

1

General Stability

2

IC50 Value

4

Inhibitors

2

Ki Value [mM]

22

KM Value [mM]

3

Localization

2

Metals/Ions

4

Molecular Weight [Da]

20

Natural Substrates/ Products (Substrates)

196

Organism

5

pH Optimum

1

pI Value

3

Purification (Commentary)

1

Reaction

5

Reaction Type

34

Reference

23

Source Tissue

5

Specific Activity [micromol/min/mg]

39

Substrates and Products (Substrate)

2

Subunits

36

Synonyms

1

Systematic Name

4

Temperature Optimum [°C]

KM Value

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KM Value on EC 1.1.99.24 - hydroxyacid-oxoacid transhydrogenase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.018 - 0.085

2-oxoglutarate

5 entries

0.06 - 0.3

4-hydroxybutyrate

5 entries

4.5

D-2-hydroxybutyrate

Rattus norvegicus

-

no activity with L-isomer, 30°C, pH 7.1

664967

0.42 - 4.5

D-2-hydroxyglutarate

2 entries

3

L-3-hydroxybutyrate

Rattus norvegicus

-

-

286147, 287797

0.0046 - 0.01

Succinic semialdehyde

2 entries

additional information

additional information

Rattus norvegicus

-

no activity with L-isomer of 2-hydroxybutyrate, Km for succinate semialdehyde is below 0.01 mM, 30°C, pH 7.1

664967

-

0.018

2-oxoglutarate

Rattus norvegicus

-

-

286147, 287797

0.077

2-oxoglutarate

Homo sapiens

-

+/-0.009 mM, in overexpressed HEK cells, in presence of 0.1 mM 4-hydroxybutyrate

664967

0.077

2-oxoglutarate

Mus musculus

-

pH 7.1, 30°C, recombinant enzyme

664967

0.085

2-oxoglutarate

Rattus norvegicus

-

pH 7.1, 30°C

664967

0.085

2-oxoglutarate

Rattus norvegicus

-

+/-0.007 mM, 30°C, pH 7.1

664967

0.06

4-hydroxybutyrate

Rattus norvegicus

-

pH 7.1, 30°C

664967

0.06

4-hydroxybutyrate

Rattus norvegicus

-

+/- 0.006 mM, 30°C, pH 7.1

664967

0.067

4-hydroxybutyrate

Homo sapiens

-

+/-0.012 mM, in overepressed HEK cells, in presence of 0.5 mM 2-oxoglutarate

664967

0.067

4-hydroxybutyrate

Mus musculus

-

pH 7.1, 30°C, recombinant enzyme

664967

0.3

4-hydroxybutyrate

Rattus norvegicus

-

-

286147, 287797

0.42

D-2-hydroxyglutarate

Rattus norvegicus

-

-

286147, 287797

4.5

D-2-hydroxyglutarate

Rattus norvegicus

-

pH 7.1, 30°C

664967

0.0046

Succinic semialdehyde

Rattus norvegicus

-

-

286147, 287797

0.01

Succinic semialdehyde

Rattus norvegicus

-

below, pH 7.1, 30°C

664967