1.1.99.24: hydroxyacid-oxoacid transhydrogenase

This is an abbreviated version!
For detailed information about hydroxyacid-oxoacid transhydrogenase, go to the full flat file.

Reaction

Synonyms

ADHFE1, alcohol dehydrogenase iron containing 1, HOT, hydroxyacid-oxoacid transhydrogenase, iron-dependent alcohol dehydrogenase ADHFe1, transhydrogenase, hydroxy acid-oxo acid

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.24 hydroxyacid-oxoacid transhydrogenase

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Results

in table

1

Activating Compound

3740

AA Sequence

1

Application

1

CAS Registry Number

1

Cloned(Commentary)

6

Cofactor

65

Disease/ Diagnostics

1

Expression

2

General Information

1

General Stability

2

IC50 Value

4

Inhibitors

2

Ki Value [mM]

22

KM Value [mM]

3

Localization

2

Metals/Ions

4

Molecular Weight [Da]

20

Natural Substrates/ Products (Substrates)

196

Organism

5

pH Optimum

1

pI Value

3

Purification (Commentary)

1

Reaction

5

Reaction Type

34

Reference

23

Source Tissue

5

Specific Activity [micromol/min/mg]

39

Substrates and Products (Substrate)

2

Subunits

36

Synonyms

1

Systematic Name

4

Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.1.99.24 - hydroxyacid-oxoacid transhydrogenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

14 entries

3-hydroxybutyrate + 2-oxoglutarate

succinic semialdehyde + D-2-hydroxyglutarate

Homo sapiens

-

-

675230

-

-

r

4-hydroxybutyrate + 2-oxoglutarate

D-2-hydroxyglutarate + succinate semialdehyde

2 entries

4-hydroxybutyrate + 2-oxoglutarate

succinic semialdehyde + D-2-hydroxyglutarate

2 entries

additional information

?

-

Homo sapiens

-

D-2-hydroxyglutaric aciduria is not associated to the enzyme activity

675230

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Acytostelium subglobosum

-

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Acytostelium subglobosum LB1

-

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Aphanomyces astaci

W4G0G7

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Aphanomyces astaci APO3

W4G0G7

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Aphanomyces invadans

A0A024TMA3

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Aphanomyces invadans NJM9701

A0A024TMA3

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Dictyostelium purpureum

F1A5G4

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Heterostelium pallidum

-

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Saprolegnia diclina

T0Q1Z2

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Saprolegnia diclina VS20

T0Q1Z2

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Saprolegnia parasitica

A0A067BRK4

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Saprolegnia parasitica CBS223.65

A0A067BRK4

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Thecamonas trahens

A0A0L0DHP5

-

741263

-

-

?

(S)-3-hydroxybutanoate + 2-oxoglutarate

acetoacetate + (R)-2-hydroxyglutarate

Thecamonas trahens ATCC 50062

A0A0L0DHP5

-

741263

-

-

?

4-hydroxybutyrate + 2-oxoglutarate

D-2-hydroxyglutarate + succinate semialdehyde

Homo sapiens

-

-

664967

-

-

?

4-hydroxybutyrate + 2-oxoglutarate

D-2-hydroxyglutarate + succinate semialdehyde

Rattus norvegicus

-

-

664967

-

-

?

4-hydroxybutyrate + 2-oxoglutarate

succinic semialdehyde + D-2-hydroxyglutarate

Mus musculus

-

recombinant enzyme in HEK-293 cells

664967

-

-

?

4-hydroxybutyrate + 2-oxoglutarate

succinic semialdehyde + D-2-hydroxyglutarate

Rattus norvegicus

-

-

664967

-

-

r