1.1.99.38: 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)
This is an abbreviated version!
For detailed information about 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent), go to the full flat file.
Reaction
Synonyms
BtrN, DOIA dehydrogenase
ECTree
Advanced search results
Cofactor
Cofactor on EC 1.1.99.38 - 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
BtrNcontains a [4Fe-4S] cluster that delivers an electron to SAM, inducing its cleavage to the common intermediate in radical SAM reactions, the 5'-deoxyadenosyl 5'-radical. BtrN contains an additional [4Fe-4S] cluster, thought to bind in contact with the substrate to facilitate loss of the second electron in the two-electron oxidation
Fe-S center
one [4Fe-4S] cluster per monomer, close interaction of both S-adenosyl-L-methione and 2-deoxy-scyllo-inosamine with the [4Fe-4S] cluster
cluster is implicated in substrate-radical oxidation
[4Fe-4S]-center
the potential of both the AdoMet [4Fe-4S] radical and auxiliary clusters can be measured simultaneously. The AdoMet [4Fe-4S] radical cluster exhibits a midpoint potential of -510 mV, while the auxiliary cluster exhibits a midpoint potential of -765 mV