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1.1.99.39: D-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about D-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.99.39

Reaction

(R)-2-hydroxyglutarate
+
acceptor
=
2-oxoglutarate
+
reduced acceptor

Synonyms

2-hydroxyglutarate dehydrogenase, AtD-2HGDH, D-2-HG dehydrogenase, D-2-HGA, D-2-hydroxyglutarate dehydrogenase, D2-hydroxyglutarate dehydrogenase, D2HDH, D2HGDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.39 D-2-hydroxyglutarate dehydrogenase

Engineering

Engineering on EC 1.1.99.39 - D-2-hydroxyglutarate dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A208T
inactive
A426T
inactive
G131X
inactive
I147S
D-2-hydroxyglutaric aciduria disease-related variant. The cofactor binding site is compromised by the single amino acid replacement. The variant forms aggregates that are unable to bind the FAD cofactor
R212W
inactive
R421H
inactive
V444A
D-2-hydroxyglutaric aciduria disease-related variant. The cofactor binding site is compromised by the single amino acid replacement. The variant forms aggregates that are unable to bind the FAD cofactor