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1.10.3.11: ubiquinol oxidase (non-electrogenic)

This is an abbreviated version!
For detailed information about ubiquinol oxidase (non-electrogenic), go to the full flat file.

Word Map on EC 1.10.3.11

Reaction

2 ubiquinol +

O2
= 2 ubiquinone + 2 H2O

Synonyms

alternative oxidase, alternative oxidase 1a, alternative oxidase 1b, alternative oxidases, AOX, AOX1, AOX1a, AOX1b, AOX1C, AOX1D, AOX2, AOX2b, AOX2b1, AOX3, AppBC, AtAOX1A, CIO, CioAB, Cox2, CrAOX1, CrAOX2, cyanide-insensitive alternative oxidase, cyanide-insensitive oxidase, cyanide-insensitive quinol oxidase, cyanide-insensitive terminal quinol oxidase, cyanide-resistant alternative oxidase, cyanide-resistant bd-type ubiquinol oxidase, cyanide-resistant oxidase, cyanide-resistant ubiquinol oxidase, CydA, CydB, cytochrome ba3 oxidase, cytochrome bb3 oxidase, cytochrome bd-II, cytochrome bd-type quinol oxidase, cytochrome bo3, cytochrome bo3 ubiquinol oxidase, heme-copper terminal oxidase, mitochondrial alternative oxidase, MpAOX, plant alternative oxidase, TAO, TAOX, trypanosomal alternative oxidase, ubiquinol:oxygen oxidoreductase

ECTree

     1 Oxidoreductases
         1.10 Acting on diphenols and related substances as donors
             1.10.3 With oxygen as acceptor
                1.10.3.11 ubiquinol oxidase (non-electrogenic)

Inhibitors

Inhibitors on EC 1.10.3.11 - ubiquinol oxidase (non-electrogenic)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,6-dihydroxy-4-[[(2E,6E,10E)-12-hydroxy-2,6,10-trimethyldodeca-2,6,10-trien-1-yl]oxy]benzoic acid
-
-
2-fluoro-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid
-
-
2-heptyl-4-hydroxyquinoline N-oxide
-
i.e. HQNO, binds stoichiometrically to the enzyme and prevents formation of the ubisemiquinone at the QH-site, but does not displace the ubiquinone-8 bound at the QH-site, enzyme binding kineticss, overview
2-Heptyl-4-hydroxyquinoline-N-oxide
-
2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-6-methylbenzoic acid
-
-
2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid
-
-
2-hydroxybenzhydroxamic acid
-
competitive inhibitor towards ubiquinol
4-[(14-bromotetradecyl)oxy]-2-hydroxybenzaldehyde
-
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4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-2-methylbenzoic acid
-
-
5-chloro-3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxy-6-methylbenzaldehyde
an ascofuranone derivative
5-chloro-3-[(2E,6E)-8-hydroxy-3,7-dimethylnona-2,6-dienyl]-2,4-dihydroxy-6-methylbenzaldehyde
an ascofuranone derivative
antimycin A
56% residual activity at 0.005 mg/ml; 56% residual activity at 0.005 mg/ml
ascochlorin
-
ascofuranone
aurachin C 1-10
15% residual activity at 0.005 mg/ml; 15% residual activity at 0.005 mg/ml
aurachin C1-10
-
prevents formation of the ubisemiquinone at the QH-site, but appears to compete for quinol binding at the QL-site, enzyme binding kineticss, overview
aurachin D
16% residual activity at 0.005 mg/ml; 16% residual activity at 0.005 mg/ml
colletochlorin B
-
cyanide
ferulenol
competitive inhibitor, binding is completely reversible
-
Gramicidin S
67% residual activity at 0.005 mg/ml; 67% residual activity at 0.005 mg/ml
LL-Z1272gamma
69% residual activity at 0.005 mg/ml; 69% residual activity at 0.005 mg/ml
methyl 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoate
-
-
methyl 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzoate
-
-
n-octyl gallate
n-propyl gallate
octyl gallate
octylgallate
Piericidin A
14% residual activity at 0.005 mg/ml; 14% residual activity at 0.005 mg/ml
propyl gallate
-
-
Salicylhydroxamic acid
salicylic hydroxamic acid
-
ubiquinol
ubiquinol-1
-
substrate inhibition
ubiquinol-2
-
substrate inhibition
ubiquinone-1
-
product inhibition, an excess amount of ubiquinol-2 is unable to suppress product inhibition with ubiquinone-1 therefore, the inhibition mode may not be competitive
ubiquinone-2
-
product inhibition
[14-(4-carboxy-3-hydroxy-5-methylphenoxy)tetradecyl](triphenyl)phosphanium
-
-
[14-(4-formyl-3-hydroxyphenoxy)tetradecyl](triphenyl)phosphanium
-
-
[14-[3-fluoro-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
-
-
[14-[3-hydroxy-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
-
-
[14-[4-(ethoxycarbonyl)-3-hydroxy-5-methylphenoxy]tetradecyl](triphenyl)phosphanium
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[14-[4-hydroxy-3-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
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additional information
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