1.10.3.15: grixazone synthase

This is an abbreviated version!
For detailed information about grixazone synthase, go to the full flat file.

Reaction

2 3-amino-4-hydroxybenzoate +

N-acetyl-L-cysteine
+ 2 O2 =
grixazone B
+ 4 H2O +
CO2

Synonyms

GriF

ECTree

     1 Oxidoreductases
         1.10 Acting on diphenols and related substances as donors
             1.10.3 With oxygen as acceptor
                1.10.3.15 grixazone synthase

Systematic Name

Systematic Name on EC 1.10.3.15 - grixazone synthase

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SYSTEMATIC NAME
IUBMB Comments
3-amino-4-hydroxybenzoate:N-acetyl-L-cysteine:oxygen oxidoreductase
A type 3 multi copper protein. The enzyme, isolated from the bacterium Streptomyces griseus, catalyses an 8 electron oxidation. Activation of the enzyme requires a copper chaperone (GriE). It also acts on 3-amino-4-hydroxybenzaldehyde, giving grixazone A. The second aldehyde group is presumably lost as formate. The enzyme also catalyses the reaction of EC 1.10.3.4 o-aminophenol oxidase.