1.11.1.13: manganese peroxidase
This is an abbreviated version!
For detailed information about manganese peroxidase, go to the full flat file.
Word Map on EC 1.11.1.13
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1.11.1.13
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lignin
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laccase
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ligninolytic
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phanerochaete
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chrysosporium
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white-rot
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basidiomycete
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decolor
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peroxidases
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pleurotus
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lignin-degrading
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trametes
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versicolor
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veratryl
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ostreatus
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straw
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mniii
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lignocellulosic
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bjerkandera
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sordida
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lignocellulolytic
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remazol
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subvermispora
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lacteus
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eryngii
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irpex
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lignin-modifying
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kraft
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sawdust
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phlebia
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adusta
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ceriporiopsis
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1-hydroxybenzotriazole
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nutrition
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lignocellulose-degrading
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ligninase
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sajor-caju
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wood-rotting
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dye-decolorizing
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tigrinus
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mnso4
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biosorption
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delignification
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delignified
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biobleaching
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degradation
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synthesis
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lentinula
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biotreatment
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non-phenolic
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industry
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decolourisation
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2,6-dimethoxyphenol
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paper production
-
low-nitrogen
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environmental protection
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biotechnology
-
biofuel production
- 1.11.1.13
- lignin
- laccase
-
ligninolytic
- phanerochaete
- chrysosporium
-
white-rot
-
basidiomycete
-
decolor
- peroxidases
- pleurotus
-
lignin-degrading
- trametes
- versicolor
-
veratryl
- ostreatus
- straw
-
mniii
-
lignocellulosic
- bjerkandera
- sordida
-
lignocellulolytic
-
remazol
- subvermispora
- lacteus
- eryngii
- irpex
-
lignin-modifying
-
kraft
- sawdust
- phlebia
- adusta
-
ceriporiopsis
- 1-hydroxybenzotriazole
- nutrition
-
lignocellulose-degrading
-
ligninase
- sajor-caju
-
wood-rotting
-
dye-decolorizing
- tigrinus
- mnso4
-
biosorption
-
delignification
-
delignified
-
biobleaching
- degradation
- synthesis
- lentinula
-
biotreatment
-
non-phenolic
- industry
-
decolourisation
- 2,6-dimethoxyphenol
- paper production
-
low-nitrogen
- environmental protection
- biotechnology
- biofuel production
Reaction
2 Mn(II)
+
2 H+
+
Synonyms
CmMnP, extralong PMnP, hybrid Mn-peroxidase, Il-MnP1, Il-MnP6, L-MnP, LeMnP2, long PMnP, manganese peroxidase, manganese peroxidase 2, manganese-dependent peroxidase, MGmn2, MGmnp1, MGmnp3, Mn-dependent (NADH-oxidizing) peroxidase, Mn2+: hydrogen peroxide oxidoreductase, Mn2+:H2O2 oxidoreductase, Mn2+:hydrogen peroxide oxidoreductase, MnP, MnP 1, MnP II, MnP-BBP6, MnP-GY, MnP-PGY, mnp1, MnP10, MnP117436, MnP12, MnP157986, MnP2, MnP3, MnP50297, MnP6, Moror_3885, MP, MrMnP1, multifunctional manganese peroxidase, Nf b19 MNP2, peroxidase, manganese, peroxidase-M2, rMnP3-BBP6, short manganese peroxidase, short MnP
ECTree
1.11.1.13 manganese peroxidaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 1.11.1.13 - manganese peroxidase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1,10-phenanthroline
-
inhibits competitive Mn(III)-malonate formation
ethylhydrazine
-
time-dependent inactivation via delta-meso-ethylheme adduct at pH 7.0, slightly stimulated by Co2+
methylhydrazine
-
slow inactivation in presence of H2O2, concentration- and time-dependent, slightly stimulated by Co2+
nitrilotriacetate
-
inhibits competitive Mn(III)-malonate formation
Pc reducer
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the activity of manganese peroxidase is inhibited by Pc reducer at concentrations higher than 0.2 mg/ml
-
phenylhydrazine
-
rapid inactivation, concentration-dependent, no heme adducts detectable, inactivation is slightly stimulated by Co2+
Sodium metavanadate
-
partially inhibits only peroxidase activity against veratryl alcohol
2-mercaptoethanol
85% inhibition at 0.1 mM, complete inhibition at 1 mM
Ca2+
30% inhibition at 10 mM, Ca2+ reduces the enzyme stability by 40%
catalase
-
inhibits oxidation of vanillylacetone completely, oxidation of NADH at high concentrations partially
-
catalase
-
inhibits oxidation of NADH in reaction mixture containing alpha-hydroxy acid
-
Cd2+
-
competitive inhibitor to Mn2+, uncompetitive to H2O2, reversibly inhibits oxidation of Mn2+ and Mn3+-mediated oxidation of 2,6-dimethoxyphenol, but not oxidation of phenols in absence of Mn2+, Cd2+ inhibits reduction of compound I and II by Mn2+ at pH 4.5 and binds at the Mn2+-binding site, kinetics of inhibition
Co2+
-
at concentrations below 4 mM in presence of H2O2 competitive inhibitor to Mn2+, slightly stimulates NaN3 or alkylhydrazine inactivation
Cu2+
-
inhibits by catalyzing the H2O2-dependent reduction of Mn3+
diphosphate
-
inhibits oxidation of 2,2-azino-di-3-ethylbenzothiazoline-6-sulfonate
diphosphate
-
diphosphate, as a Mn(III) complexing agent can negatively influence the oxidation capacity of Mn3+, which is used to verify the contribution of Mn3+ and other active species to the degradation of SMX
diphosphate
-
inhibits phenol red oxidation to 50%, NADH oxidation at high concentrations partially
H2O2
the enzyme activity is reduced by 10% as the H2O2 concentration increases from 0.1 to 4 mM
H2O2
-
inactivation fits a first-order decay, rapid initial inactivation step
H2O2
-
inhibitory at high concentrations, phenol red is the most sensitive, vanillylacetone the least sensitive substrate to inhibition, Mn2+ protects against inhibition
H2O2
1 mM, complete, irreversible inactivation of wild-type enzyme correlated with the production of methionine sulfoxide, full activity can be retained by engineering Asn-81, which might have conformational changes due to the environment of the pocket, to a non-bulky and non-oxidizable Ser
Mn2+
-
partial inhibition of oxidation of NAD(P)H at the beginning of the reaction, NADH: 0.1 mM Mn2+ causes 97% inhibition of MP1 and 72% inhibition of MP2
NaN3
-
complete inactivation within 2 min in presence of H2O2, accompanied by azidyl radical formation, prosthetic heme is converted to meso-azido adduct which is more rapidly oxidized by H2O2 than prosthetic heme, 2 equivalents of azide are oxidized before the enzyme molecule is inactivated, inactivation is slightly stimulated by Co2+
Superoxide dismutase
-
inhibits oxidation of vanillylacetone by about 80%
-
Superoxide dismutase
-
inhibits phenol red oxidation to 50%, vanillylacetone oxidation to 90%, NADH oxidation at high concentrations partially
-
Superoxide dismutase
-
inhibits oxidation of NADH in reaction mixture containing acetate
-
additional information
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not inhibited by 0.1 mM Cu2+, Co2+ or salicylic acid; not inhibited by salicylic acid
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additional information
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not inhibited by 5% ethanol, v/v; not inhibited by salicylic acid
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additional information
-
not inhibited by sodium diphosphate, mannitol, Mn3+-chelators
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