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1.11.1.17: glutathione amide-dependent peroxidase

This is an abbreviated version!
For detailed information about glutathione amide-dependent peroxidase, go to the full flat file.

Reaction

2 glutathione amide +

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H2O2
=
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glutathione amide disulfide
+ 2 H2O

Synonyms

garB, More, Prx-containing peroxidase, Prx/Grx chimeric enzyme

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                EC 1.11.1.171.11.1.17 glutathione amide-dependent peroxidase

Systematic Name

Systematic Name on EC 1.11.1.17 - glutathione amide-dependent peroxidase

for references in articles please use BRENDA:EC1.11.1.17

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SYSTEMATIC NAME
IUBMB Comments
glutathione amide:hydrogen-peroxide oxidoreductase
This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress [1]. The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase).