1.11.1.27: glutathione-dependent peroxiredoxin

This is an abbreviated version!
For detailed information about glutathione-dependent peroxiredoxin, go to the full flat file.

Reaction

2 glutathione +

Synonyms

1-Cys peroxiredoxin, 1-Cys Prdx, 1-Cys Prx, 1-CysPrx, 2-Cys peroxiredoxin, 2-Cys peroxiredoxin TPx-1, EC 1.11.1.15, glutathione peroxidase, GPX, HI0572, peroxiredoxin 6, peroxiredoxin II, peroxiredoxin VI, Pf1-Cys-Prx, PGdx, Prdx6, Prx1, Prx3, Prx6, TPx-1

ECTree

     1 Oxidoreductases

         1.11 Acting on a peroxide as acceptor

             1.11.1 Peroxidases

                1.11.1.27 glutathione-dependent peroxiredoxin

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Results	in table
1	Activating Compound
10172	AA Sequence
1	Application
15	Cloned(Commentary)
2	Crystallization (Commentary)
16	Disease/ Diagnostics
9	Expression
25	General Information
1	General Stability
1	IC50 Value
13	Inhibitors
2	kcat/KM [mM/s]
9	KM Value [mM]
12	Localization
10	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
34	Organism
2	Pathway
1	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
5	Posttranslational Modification
12	Protein Variants
11	Purification (Commentary)
1	Reaction
34	Reference
44	Source Tissue
7	Specific Activity [micromol/min/mg]
57	Substrates and Products (Substrate)
14	Subunits
71	Synonyms
1	Systematic Name
2	Temperature Stability [°C]

Activating Compound

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Activating Compound on EC 1.11.1.27 - glutathione-dependent peroxiredoxin

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

additional information

Bos taurus

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physiological mechanism for the glutathionylation of the oxidized cysteine in 1-cysPrx by its heterodimerization with glutathione-loaded glutathione S-transferase P (GST-pi) results in heterodimer formation, glutathionylation of the enzyme (1-cysPrx), and enzyme reactivation. Maximum activation of the enzyme (1-cysPrx) occurrs with a 1:1 molar ratio of glutathione-saturated glutathione S-transferase P and a 2:1 molar ratio of glutathione to enzyme (1-cysPrx)

755233

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