1.11.1.27: glutathione-dependent peroxiredoxin
This is an abbreviated version!
For detailed information about glutathione-dependent peroxiredoxin, go to the full flat file.
Word Map on EC 1.11.1.27
-
1.11.1.27
-
peroxiredoxins
-
plasmodium
-
falciparum
-
malaria
-
prxvi
-
intraerythrocytic
-
medicine
- 1.11.1.27
- peroxiredoxins
- plasmodium
- falciparum
-
malaria
- prxvi
-
intraerythrocytic
- medicine
Reaction
Synonyms
1-Cys peroxiredoxin, 1-Cys Prdx, 1-Cys Prx, 1-CysPrx, 2-Cys peroxiredoxin, 2-Cys peroxiredoxin TPx-1, EC 1.11.1.15, glutathione peroxidase, GPX, HI0572, peroxiredoxin 6, peroxiredoxin II, peroxiredoxin VI, Pf1-Cys-Prx, PGdx, Prdx6, Prx1, Prx3, Prx6, TPx-1
ECTree
Advanced search results
General Information
General Information on EC 1.11.1.27 - glutathione-dependent peroxiredoxin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
physiological function
additional information
ADV89163
the prx3 mutation impairs growth in the medium containing peroxides and reduced virulence in mice
malfunction
ADV89163
the prx3 mutation impairs growth in the medium containing peroxides and reduces virulence in mice
malfunction
Prdx6 null mice show increased lung or liver injury with exposure to hyperoxia, lipopolysaccharide (LPS), or paraquat. Prdx6 null mice as compared to wild type demonstrate increased age-related oxidative damage to their sperm chromatin
malfunction
-
enzyme haplodeficiency attenuates astro- and microglia activation around Abeta plaques promoting Abeta deposition and neuritic degeneration
malfunction
peroxiredoxin 6 down-regulation reduces cell proliferation. Enzyme silencing interferes with apoptotic signaling from CD95 but does not induce apoptosis in HepG2 cells
malfunction
-
the prx3 mutation impairs growth in the medium containing peroxides and reduced virulence in mice
-
malfunction
-
the prx3 mutation impairs growth in the medium containing peroxides and reduces virulence in mice
-
-
Prdx6 has important roles in both antioxidant defense based on its ability to reduce peroxidized membrane phospholipids and in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis
physiological function
-
Prdx6 has important roles in both antioxidant defense based on its ability to reduce peroxidized membrane phospholipids and in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis
physiological function
-
Prdx6 has important roles in both antioxidant defense based on its ability to reduce peroxidized membrane phospholipids and in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis
physiological function
-
Prdx6 has important roles in both antioxidant defense based on its ability to reduce peroxidized membrane phospholipids and in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis
physiological function
ADV89163
Prx3 is essential for survival under oxidative stress and pathogenesis of Vibrio vulnificus
physiological function
ADV89163
Prx3 is essential for survival under oxidative stress and virulence in mice
physiological function
cells over-expressing Prdx6 show an increase in survival compared to control when oxidatively challenged with hydroperoxides, paraquat, UVB radiation, or OH generated by Cu2+/ascorbate. Prx6 over-expression through adenoviral-mediated intratracheal delivery of a Prdx6 expression vector or in transgenic mice protected lungs from hyperoxic injury. Prdx6 has an important role in the repair of peroxidized cell membranes, at least in lungs, and that both its PHGPx and PLA2 activities play important roles
physiological function
function of PRDX6 in osteogenic differentiation, bone regeneration, and bone development. It is proposed that PRDX6 is a critical enzyme for cell fate determination of dental pulp stem cell into osteoblast lineages
physiological function
peroxiredoxins, the family of non-selenium glutathione peroxidases, are important antioxidant enzymes that defend a system from the toxic reactive oxygen species
physiological function
Prdx6 plays crucial roles in lung phospholipid metabolism, lipid peroxidation repair, and inflammatory signaling. Mice that over-express Prdx6 show a greater increase in the growth of lung tumors compared to wild-type animals. Both aiPLA2 and Prdx6 peroxidase activities are implicated in lung tumor development through the regulation of redox-sensitive pathways such as MAPK, JNK, JAK/STAT, and AP-1
physiological function
Prdx6 plays crucial roles in lung phospholipid metabolism, lipid peroxidation repair, and inflammatory signaling. Prdx6 prevents oxidative stress in human retinal pigment epithelial cells by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway. Prdx6 is necessary to prevent cataract formation and to limit aging-induced oxidative stress in the eye
physiological function
-
Prx3 is essential for survival under oxidative stress and pathogenesis of Vibrio vulnificus
-
physiological function
-
Prx3 is essential for survival under oxidative stress and virulence in mice
-
-
regulation of Prdx6 gene regulation, overview. Transcription is activated by binding of the transcription factor Nrf2 to the ARE whereas transcription is inhibited by the binding of Nrf3. Prdx6 expression also is responsive to hormonal regulation
additional information
-
regulation of Prdx6 gene regulation, overview. Transcription is activated by binding of the transcription factor Nrf2 to the ARE whereas transcription is inhibited by the binding of Nrf3. Prdx6 expression also is responsive to hormonal regulation
additional information
-
regulation of Prdx6 gene regulation, overview. Transcription is activated by binding of the transcription factor Nrf2 to the ARE whereas transcription is inhibited by the binding of Nrf3. Prdx6 expression also is responsive to hormonal regulation
additional information
-
regulation of Prdx6 gene regulation, overview. Transcription is activated by binding of the transcription factor Nrf2 to the ARE whereas transcription is inhibited by the binding of Nrf3. Prdx6 expression also is responsive to hormonal regulation