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1.11.1.6: catalase

This is an abbreviated version!
For detailed information about catalase, go to the full flat file.

Word Map on EC 1.11.1.6

Reaction

2 H2O2 =

O2
+ 2 H2O

Synonyms

Ab-catalase, BNC, caperase, CAT, CAT-1, CAT-A, CAT-P, Cat1.4, CatA, catalase, catalase A, catalase C, catalase form III, catalase P, catalase-1, catalase-A, catalase-peroxidase, catalase-phenol oxidase, CatB, CATC, CatF, CatG, CatP, CATPO, CcmC, CP, equilase, H2O2:H2O2 oxidoreductase, haem catalase, HPI-A, HPI-B, HPII, HTHP, hydrogen peroxide oxidoreductase, KAT, Kat E catalase, KatA, KatB, KatC, KatP, KpA, manganese catalase, More, optidase, PktA, polyethylene glycol-catalase, tyrosine-coordinated heme protein, VktA

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.6 catalase

Activating Compound

Activating Compound on EC 1.11.1.6 - catalase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-Amino-1,2,4-triazole
-
18% activation of catalase activity and unaltered peroxidase activity at 0.1 mM, 56% activation of catalase activity and 21% activation of peroxidase activity at 10 mM
all-trans-retinol
-
treatment of cultured Sertoli cells leads to activation of catalase by increasing its protein content, but without alteration of its mRNA expression. Retinol treatment also increases cell lipoperoxidation and intracellular reactive species production. All effects induced by retinol are inhibited by the antioxidant Trolox
AnkB
-
the periplasmic ankyrin-like protein is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide
-
bensulfuron methyl
Ca2+
-
stimulates
chloramphenicol
-
24% activation at 0.1 mM in 1 min
Fe2+
-
the catalase activity shows a strong positive dependence on the intracellular iron concentration in Fe-replete medium and low activity under Fe-limited growth conditions
hemin
-
0.002-0.01 mM required for half-maximal to maximal enzyme production
histidine
-
stimulation
Ibuprofen
-
induces a variety of enzymes associated with the oxidative stress response, including catalase, glucose-6-phosphate-dehydrogenase, and aldehyde reductase in a dose-related manner
imidazole
Leucine-enkephalin
-
the intracellular and extracellular CAT activity is increased with increasing concentration (0.001-0.05 mg/ml) of leucine-enkephalin
Mg2+
-
stimulates
Mn2+
-
stimulates
NaCl
-
highest activity for catalase at 2 M, for peroxidase at 1 M
NADPH
addition of NADPH stimulates the activity of CatP in a dose-dependent manner most likely by preventing the inactivation from oxidative damage through its substrate H2O2
Ni2+
-
stimulates
peracetic acid
-
low doses induce enzyme promoter activity and increase total enzymic activity in cell extracts
phosphatidylcholine
-
progesterone receptor isoform B
-
-
-
quinclorac
retinal
-
retinal (0.007 and 0.014 mM) increases CAT activity after 24 h of treatment
retinoic acid
-
retinoic acid (100 nM and 0.001 mM) increases CAT activity after 24 h of treatment
Sodium arsenate
Tris
-
stimulation at 10 mM
additional information
-