1.11.1.8: iodide peroxidase
This is an abbreviated version!
For detailed information about iodide peroxidase, go to the full flat file.
Word Map on EC 1.11.1.8
-
1.11.1.8
-
thyroglobulin
-
tsh
-
autoimmune
-
hypothyroidism
-
autoantibody
-
thyroxin
-
women
-
graves
-
tpoabs
-
hashimoto
-
thyrotropin
-
thyroid-stimulating
-
pregnancy
-
subclinical
-
euthyroidism
-
triiodothyronine
-
goiter
-
follicular
-
overt
-
thyrocytes
-
anti-tpo
-
antithyroid
-
symporter
-
organification
-
trimester
-
levothyroxine
-
autoantigens
-
thyroid-specific
-
frtl-5
-
guaiacol
-
methimazole
-
lactoperoxidase
-
radioiodine
-
propylthiouracil
-
goitrous
-
thyrotoxicosis
-
antibody-negative
-
multinodular
-
analysis
-
peroxidase-catalyzed
-
hypothalamic-pituitary-thyroid
-
ophthalmopathy
-
gadas
-
tsh-induced
-
anti-thyroglobulin
-
medicine
-
thyroid-associated
-
tsh-stimulated
-
chloroperoxidase
-
synthesis
-
nodosum
-
haloperoxidases
-
thyrotoxic
- 1.11.1.8
- thyroglobulin
- tsh
- autoimmune
- hypothyroidism
- autoantibody
- thyroxin
- women
- graves
-
tpoabs
- hashimoto
- thyrotropin
-
thyroid-stimulating
- pregnancy
-
subclinical
-
euthyroidism
- triiodothyronine
- goiter
-
follicular
-
overt
- thyrocytes
-
anti-tpo
-
antithyroid
-
symporter
-
organification
-
trimester
- levothyroxine
- autoantigens
-
thyroid-specific
-
frtl-5
- guaiacol
- methimazole
- lactoperoxidase
-
radioiodine
- propylthiouracil
-
goitrous
- thyrotoxicosis
-
antibody-negative
-
multinodular
- analysis
-
peroxidase-catalyzed
-
hypothalamic-pituitary-thyroid
-
ophthalmopathy
-
gadas
-
tsh-induced
-
anti-thyroglobulin
- medicine
-
thyroid-associated
-
tsh-stimulated
- chloroperoxidase
- synthesis
- nodosum
- haloperoxidases
-
thyrotoxic
Reaction
2 iodide
+
Synonyms
bromoperoxidase, high-molecular weight-thyroid peroxidase, HMW-TPO, hrTPO, hTPO, iodide peroxidase-tyrosine iodinase, iodinase, iodoperoxidase (heme type), thyroid peroxidase, thyroperoxidase, TPO, TPOX, TPQ, tyrosine iodinase, vanadium bromoperoxidase, vBPO
ECTree
1.11.1.8 iodide peroxidaseAdvanced search results
results (
results (Reference
top
Reference on EC 1.11.1.8 - iodide peroxidase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Coval, M.L.; Taurog, A.
Purification and iodinating activity of hog thyroid peroxidase
J. Biol. Chem.
242
5510-5523
1967
Sus scrofa
Mahajani, M.; Haldar, I.; Datta, A.G.
Purification and properties of an iodide peroxidase from submaxillary gland of goat
Eur. J. Biochem.
37
541-552
1973
Capra hircus
Neary, J.T.; Soodak, M.; Maloof, F.
Iodination by thyroid peroxidase
Methods Enzymol.
107
445-475
1984
Bos taurus, Rattus norvegicus, Sus scrofa
Ohtaki, S.; Nakagawa, H.; Nakamura, S.; Nakamura, M.; Yamazaki, I.
Characterization of hog thyroid peroxidase
J. Biol. Chem.
260
441-448
1985
Sus scrofa
Czarnocka, B.; Ruf, J.; Ferrand, M.; Carayon, P.; Lissitzky, S.
Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases
FEBS Lett.
190
147-152
1985
Homo sapiens
Divi, R.L.; Doerge, D.R.
Inhibition of thyroid peroxidase by dietary flavonoids
Chem. Res. Toxicol.
9
16-23
1996
Sus scrofa
Fan, J.L.; Patibandla, S.A.; Kimura, S.; Rao, T.N.; Desai, R.K.; Seetharamaiah, G.S.; Kurosky, A.; Prabhakar, B.S.
Purification and characterization of a recombinant human thyroid peroxidase expressed in insect cells
J. Autoimmun.
9
529-536
1996
Homo sapiens
Grennan Jones, F.; Wolstenholme, A.; Fowler, S.; Smith, S.; Ziemnicka, K.; Bradbury, J.; Furmaniak, J.; Smith, B.R.
High-level expression of recombinant immunoreactive thyroid peroxidase in the High Five insect cell line
J. Mol. Endocrinol.
17
165-174
1996
Homo sapiens
Gardas, A.; Lewartowska, A.; Sutton, B.J.; Pasieka, Z.; McGregor, M.; Banga, J.P.
Human thyroid peroxidase (TPO) isoforms, TPO-1 and TPO-2: Analysis of protein expression in Graves' thyroid tissue
J. Clin. Endocrinol. Metab.
82
3752-3756
1997
Homo sapiens
Guo, J.; McLachlan, S.M.; Hutchison, S.; Rapoport, B.
The greater glycan content of recombinant human thyroid peroxidase of mammalian than of insect cell origin facilitates purification to homogeneity of enzymically protein remaining soluble at high concentration
Endocrinology
139
999-1005
1998
Homo sapiens
Gardas, A.; Sutton, B.J.; Piotrowska, U.; Pasieka, Z.; Barnett, P.S.; Huang, G.; McGregor, A.M.; Banga, J.P.
Distinct immunological and biochemical properties of thyroid peroxidase purified from human thyroid glands and recombinant protein produced in insect cells
Biochim. Biophys. Acta
1433
229-239
1999
Homo sapiens
Gut, P.; Grennan Jones, F.; Sullivan, A.; Ziemnicka, K.; Smith, S.; Jaskolski, D.; Furmaniak, J.; Rees Smith, B.
Recombinant human thyroid peroxidase produced in insect cells has similar properties to native human thyroid peroxidase
Thyroid
10
543-550
2000
Homo sapiens
Carvalho, D.P.; Ferreira, A.C.; Coelho, S.M.; Moraes, J.M.; Camacho, M.A.; Rosenthal, D.
Thyroid peroxidase activity is inhibited by amino acids
Braz. J. Med. Biol. Res.
33
355-361
2000
Homo sapiens
Grintsevich, E.E.; Senchuk, V.V.; Puchkaev, A.V.; Metelitza, D.I.
Propyl gallate inhibition of iodide and tetramethylbenzidine oxidation catalyzed by human thyroid peroxidase
Biochemistry (Moscow)
65
924-932
2000
Homo sapiens
Sugawara, M.; Sugawara, Y.; Wen, K.; Giulivi, C.
Generation of oxygen free radicals in thyroid cells and inhibition of thyroid peroxidase
Exp. Biol. Med.
227
141-146
2002
Sus scrofa
Sentchouk, V.V.; Grintsevich, E.E.
Oxidation of benzidine and its derivatives by thyroid peroxidase
Biochemistry
69
201-207
2004
Homo sapiens
Masini-Repiso, A.M.; Bonaterra, M.; Spitale, L.; Di Fulvio, M.; Bonino, M.I.; Coleoni, A.H.; Orgnero-Gaisan, E.
Ultrastructural localization of thyroid peroxidase, hydrogen peroxide-generating sites, and monoamine oxidase in benign and malignant thyroid diseases
Hum. Pathol.
35
436-446
2004
Homo sapiens
Bresson, D.; Pugniere, M.; Roquet, F.; Rebuffat, S.A.; N-Guyen B.; Cerutti, M.; Guo, J.; McLachlan, S.M.; Rapoport, B.; Estienne, V.; Ruf, J.; Chardes, T.; Peraldi-Roux, S.
Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies
J. Biol. Chem.
279
39058-39067
2004
Homo sapiens
Umeki, K.; Kawano, J.i.; Yamamoto, I.; Aratake, Y.; Kotani, T.
Comparative analysis and characterization of mutated thyroid peroxidases with disturbance expressed on the cell surface
Mol. Cell. Endocrinol.
223
77-84
2004
Homo sapiens
Tsyganova, O.V.; Kiseleva, E.P.; Vashkevich, I.I.; Pryadko, A.G.; Sviridov, O.V.
Characteristics of immunoaffinity chromatography and a new method for isolation of human thyroid peroxidase from subcellular fractions of thyroid gland
Appl. Biochem. Microbiol.
42
210-219
2006
Homo sapiens
-
Ruf, J.; Carayon, P.
Structural and functional aspects of thyroid peroxidase
Arch. Biochem. Biophys.
445
269-277
2006
Homo sapiens, Mus musculus, Sus scrofa
Ferreira, A.C.; Neto, J.C.; da Silva, A.C.; Kuster, R.M.; Carvalho, D.P.
Inhibition of thyroid peroxidase by Myrcia uniflora flavonoids
Chem. Res. Toxicol.
19
351-355
2006
Homo sapiens
Bresson, D.; Rebuffat, S.A.; Nguyen, B.; Banga, J.P.; Gardas, A.; Peraldi-Roux, S.
New insights into the conformational dominant epitopes on thyroid peroxidase recognized by human autoantibodies
Endocrinology
146
2834-2844
2005
Homo sapiens
Dubska, M.; Banga, J.P.; Plochocka, D.; Hoser, G.; Kemp, E.H.; Sutton, B.J.; Gardas, A.; Gora, M.
Structural insights into autoreactive determinants in thyroid peroxidase composed of discontinuous and multiple key contact amino acid residues contributing to epitopes recognized by patients autoantibodies
Endocrinology
147
5995-6003
2006
Homo sapiens
Ehrenshaft, M.; Mason, R.P.
Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping
Free Radic. Biol. Med.
41
422-430
2006
Homo sapiens
Rebuffat, S.A.; Bresson, D.; Nguyen, B.; Peraldi-Roux, S.
The key residues in the immunodominant region 353-363 of human thyroid peroxidase were identified
Int. Immunol.
18
1091-1099
2006
Homo sapiens
Takabayashi, S.; Umeki, K.; Yamamoto, E.; Suzuki, T.; Okayama, A.; Katoh, H.
A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse
Mol. Endocrinol.
20
2584-2590
2006
Mus musculus
Lima, L.P.; Barros, I.A.; Lisboa, P.C.; Araujo, R.L.; Silva, A.C.; Rosenthal, D.; Ferreira, A.C.; Carvalho, D.P.
Estrogen effects on thyroid iodide uptake and thyroperoxidase activity in normal and ovariectomized rats
Steroids
71
653-659
2006
Rattus norvegicus
Verhaeghe, E.; Buisson, D.; Zekri, E.; Leblanc, C.; Potin, P.; Ambroise, Y.
A colorimetric assay for steady-state analyses of iodo- and bromoperoxidase activities
Anal. Biochem.
379
60-65
2008
Ascophyllum nodosum
Nakagawa, T.; Maruyama, K.; Takeyama, H.; Matsunaga, T.
Determination of microsatellite repeats in the human thyroid peroxidase (TPOX) gene using an automated gene analysis system with nanoscale engineered biomagnetite
Biosens. Bioelectron.
22
2276-2281
2007
Homo sapiens
Rivolta, C.M.; Louis-Tisserand, M.; Varela, V.; Gruneiro-Papendieck, L.; Chiesa, A.; Gonzalez-Sarmiento, R.; Targovnik, H.M.
Two compound heterozygous mutations (c.215delA/c.2422T-->C and c.387delC/c.1159G-->A) in the thyroid peroxidase gene responsible for congenital goitre and iodide organification defect
Clin. Endocrinol. (Oxf.)
67
238-246
2007
Homo sapiens
Schmutzler, C.; Bacinski, A.; Gotthardt, I.; Huhne, K.; Ambrugger, P.; Klammer, H.; Schlecht, C.; Hoang-Vu, C.; Grueters, A.; Wuttke, W.; Jarry, H.; Koehrle, J.
The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase
Endocrinology
148
2835-2844
2007
Homo sapiens
Poncin, S.; Lengele, B.; Colin, I.M.; Gerard, A.C.
Differential interactions between Th1/Th2, Th1/Th3, and Th2/Th3 cytokines in the regulation of thyroperoxidase and dual oxidase expression, and of thyroglobulin secretion in thyrocytes in vitro
Endocrinology
149
1534-1542
2008
Homo sapiens, Rattus norvegicus
Avbelj, M.; Tahirovic, H.; Debeljak, M.; Kusekova, M.; Toromanovic, A.; Krzisnik, C.; Battelino, T.
High prevalence of thyroid peroxidase gene mutations in patients with thyroid dyshormonogenesis
Eur. J. Endocrinol.
156
511-519
2007
Homo sapiens
Ginabreda, M.G.; Cardoso, L.C.; Nobrega, F.M.; Ferreira, A.C.; Goncalves, M.D.; Vaisman, M.; Carvalho, D.P.
Negative correlation between thyroperoxidase and dual oxidase H2O2-generating activities in thyroid nodular lesions
Eur. J. Endocrinol.
158
223-227
2008
Homo sapiens
Pedersen, I.B.; Laurberg, P.; Knudsen, N.; J?rgensen, T.; Perrild, H.; Ovesen, L.; Rasmussen, L.B.
Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study
Eur. J. Endocrinol.
158
367-373
2008
Homo sapiens
Wong, E.; Rosen, L.S.; Mulay, M.; Vanvugt, A.; Dinolfo, M.; Tomoda, C.; Sugawara, M.; Hershman, J.M.
Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity
Thyroid
17
351-355
2007
Homo sapiens
McLachlan, S.M.; Rapoport, B.
Thyroid peroxidase as an autoantigen
Thyroid
17
939-948
2007
Homo sapiens
Simm, D.; Pfarr, N.; Pohlenz, J.; Prawitt, D.; Doerr, H.G.
Two novel mutations in the human thyroid peroxidase (TPO) gene: genetics and clinical findings in four children
Acta Paediatr.
98
1057-1061
2009
Homo sapiens
Palazzolo, D.L.; Jansen, K.P.
The minimal arsenic concentration required to inhibit the activity of thyroid peroxidase activity in vitro
Biol. Trace Elem. Res.
126
49-55
2008
Homo sapiens
Savin, S.; Cvejic, D.; Isic, T.; Paunovic, I.; Tatic, S.; Havelka, M.
Thyroid peroxidase and galectin-3 immunostaining in differentiated thyroid carcinoma with clinicopathologic correlation
Hum. Pathol.
39
1656-1663
2008
Homo sapiens
McDonald, D.O.; Pearce, S.H.
Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity
J. Mol. Med.
87
971-980
2009
Homo sapiens
Wang, Y.; Zhao, X.; Jiang, X.; Hua, X.; Xu, N.
Molecular characterization of thyroid peroxidase gene in porcine (Sus scrofa)
J. Genet. Genomics
37
381-388
2010
Sus scrofa (P09933), Sus scrofa
Cianfarani, F.; Baldini, E.; Cavalli, A.; Marchioni, E.; Lembo, L.; Teson, M.; Persechino, S.; Zambruno, G.; Ulisse, S.; Odorisio, T.; DArmiento, M.
TSH receptor and thyroid-specific gene expression in human skin
J. Invest. Dermatol.
130
93-101
2010
Homo sapiens
Song, M.; Kim, Y.J.; Park, Y.K.; Ryu, J.C.
Changes in thyroid peroxidase activity in response to various chemicals
J. Environ. Monit.
14
2121-2126
2012
Homo sapiens
Godlewska, M.; Gora, M.; Buckle, A.M.; Porebski, B.T.; Kemp, E.H.; Sutton, B.J.; Czarnocka, B.; Banga, J.P.
A redundant role of human thyroid peroxidase propeptide for cellular, enzymatic, and immunological activity
Thyroid
24
371-382
2014
Homo sapiens
Palazzolo, D.L.; Ely, E.A.
Arsenic trioxide and reduced glutathione act synergistically to augment inhibition of thyroid peroxidase activity in vitro
Biol. Trace Elem. Res.
165
110-117
2015
Homo sapiens
Maruta, J.; Hashimoto, H.; Yamashita, H.; Noguchi, H.; Noguchi, S.; Kobayashi, T.K.; Tsuneoka, H.; Takahashi, M.
Value of thyroid specific peroxidase and Ki-67 stains in preoperative cytology for thyroid follicular tumors
Diagn. Cytopathol.
43
202-209
2015
Homo sapiens
Kaur, P.; Patil, H.; Bhanushali, P.; Badgujar, S.; Gupta, A.
Purification of recombinant human thyroid peroxidase (hTPO) from AD293 mammalian cells
Int. J. Biol. Macromol.
106
87-94
2018
Homo sapiens
Belforte, F.S.; Targovnik, A.M.; Gonzalez-Lebrero, R.M.; Osorio Larroche, C.; Citterio, C.E.; Gonzalez-Sarmiento, R.; Miranda, M.V.; Targovnik, H.M.; Rivolta, C.M.
Kinetic characterization of human thyroperoxidase. Normal and pathological enzyme expression in Baculovirus system a molecular model of functional expression
Mol. Cell. Endocrinol.
404
9-15
2015
Homo sapiens (P07202), Homo sapiens
Godlewska, M.; Arczewska, K.; Rudzinska, M.; Lyczkowska, A.; Krasuska, W.; Hanusek, K.; Ruf, J.; Kiedrowski, M.; Czarnocka, B.
Thyroid peroxidase (TPO) expressed in thyroid and breast tissues shows similar antigenic properties
PLoS ONE
12
e0179066
2017
Homo sapiens
Caballero, Y.; Lopez-Tomassetti, E.M.; Favre, J.; Santana, J.R.; Cabrera, J.J.; Hernandez, J.R.
The value of thyroperoxidase as a prognostic factor for differentiated thyroid cancer - a long-term follow-up study
Thyroid Res.
8
12
2015
Homo sapiens
Habza-Kowalska, E.; Gawlik-Dziki, U.; Dziki, D.
Mechanism of action and interactions between thyroid peroxidase and lipoxygenase inhibitors derived from plant sources
Biomolecules
9
663
2019
Sus scrofa (P09933)
Rahnama, R.; Mahmoudi, A.R.; Kazemnejad, S.; Salehi, M.; Ghahiri, A.; Soltanghoraee, H.; Vafaei, S.; Rezaei, A.; Zarnani, A.H.
Thyroid peroxidase in human endometrium and placenta a potential target for anti-TPO antibodies
Clin. Exp. Med.
21
79-88
2021
Homo sapiens (P07202), Homo sapiens
Williams, D.E.; Le, S.N.; Hoke, D.E.; Chandler, P.G.; Gora, M.; Godlewska, M.; Banga, J.P.; Buckle, A.M.
Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease
Endocrinology
161
1-16
2020
Homo sapiens (P07202)
Habza-Kowalska, E.; Kaczor, A.A.; Zuk, J.; Matosiuk, D.; Gawlik-Dziki, U.
Thyroid peroxidase activity is inhibited by phenolic compounds - impact of interaction
Molecules
24
2766
2019
Sus scrofa (P09933)
Godlewska, M.; Krasuska, W.; Czarnocka, B.
Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines
PLoS ONE
13
e0193624
2018
Homo sapiens (P07202), Homo sapiens
Lou, Y.; Ji, G.; Liu, Q.; Wang, P.; Zhang, R.; Zhang, Y.; Liu, X.
Secretory expression and scale-up production of recombinant human thyroid peroxidase via baculovirus/insect cell system in a wave-type bioreactor
Protein Expr. Purif.
149
7-12
2018
Homo sapiens (P07202), Homo sapiens
Dong, H.; Godlewska, M.; Wade, M.G.
A rapid assay of human thyroid peroxidase activity
Toxicol. In Vitro
62
104662
2020
Homo sapiens (P07202), Homo sapiens
html completed
