1.11.1.9: glutathione peroxidase

This is an abbreviated version!
For detailed information about glutathione peroxidase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

2-SeCD, 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate, 6P229, ADA-Te-OH, ARMEP24, AtGPX1, ATGPX3, c-GPx4, Cellular glutathione peroxidase, cgd3_460, cGPx, Cuticular glycoprotein GP29, DI29, ebselen, EGLP, Epididymis-specific glutathione peroxidase-like protein, Extracellular glutathione peroxidase, G-6137, Gastrointestinal glutathione peroxidase, glutathione peroxidase 1, glutathione peroxidase 2, glutathione peroxidase 3, glutathione peroxidase 4, glutathione peroxidase Gpx2, glutathione peroxidase Gpx3, glutathione peroxidase-1, glutathione peroxidase-2, glutathione peroxidase-3, glutathione peroxidase-4, glutathione-dependent peroxidase I, glutathione:hydrogen-peroxide oxidoreductase, GP30, GPRP, GPX, Gpx-1, GPx-2, GPx-3, GPx-4, GPx-5, GPx-6, GPx-7, GPx-8, GPX1, Gpx2, GPX3, GPx4, GPX5, GSH peroxidase, GSH-Px, GSHPx, GSHPx-GI, intracellular GpX, m-GPx4, Major androgen-regulated protein, Major surface antigen GP29, n-GPx4, Nt-SubC08, Odorant-metabolizing protein RY2D1, Os02g0664000, OsGPX5, peroxidase, glutathione, PGdx, pGPx, PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, nuclear form, phospholipid hydroperoxide Gpx, plasma glutathione peroxidase, prion protein Ure2, reduced glutathione peroxidase, Salt-associated protein, Se-GPx, Se-hGSTZ1-1, Se-scFv-B3, secreted GpX, SeGPx, selenium containing glutathione transferase zeta1-1, selenium-dependent glutathione peroxidase, selenium-glutathione peroxidase, seleno-dependent glutathione peroxidase 1, selenosubtilisin, snGPx, TcGPXI, TTHERM_00046090, TTHERM_00046110, TTHERM_01099010, Ure2

ECTree

     1 Oxidoreductases

         1.11 Acting on a peroxide as acceptor

             1.11.1 Peroxidases

                1.11.1.9 glutathione peroxidase

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Results	in table
18	Activating Compound
1510	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
9	Crystallization (Commentary)
13419	Disease/ Diagnostics
27	Expression
20	General Information
7	General Stability
77	Inhibitors
4	kcat/KM [mM/s]
4	Ki Value [mM]
63	KM Value [mM]
90	Localization
62	Metals/Ions
52	Molecular Weight [Da]
122	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
228	Organism
2	Oxidation Stability
7	Pathway
25	PDB ID
20	pH Optimum
5	pH Range
7	pH Stability
4	pI Value
2	Posttranslational Modification
15	Protein Variants
39	Purification (Commentary)
3	Reaction
3	Reaction Type
199	Reference
269	Source Tissue
45	Specific Activity [micromol/min/mg]
8	Storage Stability
253	Substrates and Products (Substrate)
62	Subunits
216	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
5	Temperature Range [°C]
4	Temperature Stability [°C]
23	Turnover Number [1/s]

pH Stability

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pH Stability on EC 1.11.1.9 - glutathione peroxidase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

2

Mammalia

-

complete inactivation but reactivation by neutralization

396605

5

Homo sapiens

-

extremely unstable below

396616

6.8 - 8

Rattus norvegicus

-

a decrease in pH to 6.8 or an increase to 8.0 drastically suppresses the enzyme activity, since at these pH values, glutathione peroxidase becomes unstable

695719

7 - 10

Bos taurus

-

-

396611

7.4 - 8.9

Homo sapiens

P22352

-

743791

9.8

Homo sapiens

P22352

93% loss of activity

743791

additional information

Homo sapiens

-

unstable at low pH

396643