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1.11.2.4: fatty-acid peroxygenase

This is an abbreviated version!
For detailed information about fatty-acid peroxygenase, go to the full flat file.

Word Map on EC 1.11.2.4

Reaction

fatty acid
+
H2O2
=
3- or 2-hydroxy fatty acid
+
H2O

Synonyms

alpha-fatty acid hydroxylase, CYP152A1, CYP152A2, CYP152B1, CYP505, cytochrome P450 monooxygenase, cytochrome P450BSbeta, fatty-acid hydroxylase, fatty-acid subterminal hydroxylase, hydrogen peroxide-dependent cytochrome P450BSbeta, hydrogen peroxide-dependent fatty acid alpha-hydroxylase, hydrogen peroxide-dependent peroxygenase cytochrome P450, P450 BM-3 peroxygenase 21B3, P450 peroxygenase, P450BSbeta, P450CLA, P450foxy, P450SPalpha, peroxygenase cytochrome P450, peroxygenase P450, peroxygenase P450SPalpha

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.4 fatty-acid peroxygenase

Inhibitors

Inhibitors on EC 1.11.2.4 - fatty-acid peroxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3,5,3',5'-tetramethylbenzidine
3,5,3',5'-tetramethylbenzidine as an additional substrate intercepts the hydroxylation of myristic acid
H2O2
although a high concentration of hydrogen peroxide of 0.2 mM is necessary for high activities of the enzyme, it leads to a fast enzyme inactivation within 2-4 min
myristic acid
myristic acid hydroxylation is inhibited by 3,5,3',5'-tetramethylbenzidine oxidation in a 3,5,3',5'-tetramethylbenzidine concentration-dependent manner
additional information
-
the fatty acid alpha-hydroxylase activity of P450SPbeta is not affected when 80% of CO (by volume) is used as the gas phase in the reaction
-