1.11.2.4: fatty-acid peroxygenase

This is an abbreviated version!
For detailed information about fatty-acid peroxygenase, go to the full flat file.

Reaction

Synonyms

alpha-fatty acid hydroxylase, CYP152A1, CYP152A2, CYP152B1, CYP505, cytochrome P450 monooxygenase, cytochrome P450BSbeta, fatty-acid hydroxylase, fatty-acid subterminal hydroxylase, hydrogen peroxide-dependent cytochrome P450BSbeta, hydrogen peroxide-dependent fatty acid alpha-hydroxylase, hydrogen peroxide-dependent peroxygenase cytochrome P450, P450 BM-3 peroxygenase 21B3, P450 peroxygenase, P450BSbeta, P450CLA, P450foxy, P450SPalpha, peroxygenase cytochrome P450, peroxygenase P450, peroxygenase P450SPalpha

ECTree

     1 Oxidoreductases

         1.11 Acting on a peroxide as acceptor

             1.11.2 Peroxygenases

                1.11.2.4 fatty-acid peroxygenase

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All data fields related to EC 1.11.2.4

Results	in table
183	AA Sequence
10	Cloned(Commentary)
6	Cofactor
2	Crystallization (Commentary)
1	General Information
5	Inhibitors
11	KM Value [mM]
2	Localization
4	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
14	Organism
8	PDB ID
24	Protein Variants
7	Purification (Commentary)
1	Reaction
6	Reaction Type
14	Reference
2	Source Tissue
43	Substrates and Products (Substrate)
2	Subunits
35	Synonyms
1	Systematic Name

Systematic Name

Systematic Name on EC 1.11.2.4 - fatty-acid peroxygenase

for references in articles please use BRENDA:EC1.11.2.4

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SYSTEMATIC NAME

IUBMB Comments

fatty acid:hydroperoxide oxidoreductase (RH-hydroxylating)

A cytosolic heme-thiolate protein with sequence homology to P-450 monooxygenases. Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function. Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis). Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalysed by the common P-450s. A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated. Oxidizes the peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction.