1.12.1.4: hydrogenase (NAD+, ferredoxin)
This is an abbreviated version!
For detailed information about hydrogenase (NAD+, ferredoxin), go to the full flat file.
Word Map on EC 1.12.1.4
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1.12.1.4
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desulfovibrio
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hydrogenases
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desulfuricans
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nickel-iron
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diiron
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dinuclear
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fructosovorans
- 1.12.1.4
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desulfovibrio
- hydrogenases
- desulfuricans
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nickel-iron
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diiron
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dinuclear
- fructosovorans
Reaction
2 H2 + + 2 oxidized ferredoxin = 5 H+ + + 2 reduced ferredoxin
Synonyms
bifurcating [FeFe] hydrogenase, electron-bifurcating ferredoxin- and NAD-dependent hydrogenase, Fe-only hydrogenase, HydABC, HydC, HydF, iron hydrogenase, NAD(P)+-linked [FeFe]-hydrogenase, [FeFe]-hydrogenase, [FeFe]-type hydrogenase
ECTree
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Cofactor
Cofactor on EC 1.12.1.4 - hydrogenase (NAD+, ferredoxin)
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4Fe-4S-center
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displays electron paramagnetic resonance signals characteristic of oxidized [3Fe-4S]+ cluster. Cysteine residues C302, C353, and C356 are strictly required for the binding of the [4Fe-4S] cluster, whereas the fourth ligand of the coordination sphere can vary depending on the molecular environment created by local residues and/or experimental conditions
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the alpha subunit contains two [2Fe-2S] clusters and three [4Fe-4S] clusters, the beta subunit contains three [4Fe-4S] clusters and one [2Fe-2S] clusters, the gamma subunit contains one [2Fe-2S] cluster
iron-sulfur centre
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subunit HydA (63 kDa) is predicted to harbor the H cluster, i.e., the [6Fe4S] hydrogenase active site, three [4Fe4S] clusters, and one [2Fe2S] cluster. Subunit HydB (67 kDa) is predicted to harbor three [4Fe4S] clusters, a flavin binding site, and an NAD binding site. HydC (17 kDa) is predicted to harbor one [2Fe2S] cluster