1.12.98.3: Methanosarcina-phenazine hydrogenase
This is an abbreviated version!
For detailed information about Methanosarcina-phenazine hydrogenase, go to the full flat file.
Word Map on EC 1.12.98.3
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1.12.98.3
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methane
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methanogens
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heterodisulfide
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hydrogenases
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methanogenesis
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hyperthermophile
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methanobacterium
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formylmethanofuran
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nickel
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reductases
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mazei
- 1.12.98.3
- methane
-
methanogens
-
heterodisulfide
- hydrogenases
-
methanogenesis
-
hyperthermophile
-
methanobacterium
- formylmethanofuran
- nickel
- reductases
- mazei
Reaction
Synonyms
F420 non-reducing hydrogenase, membrane-bound hydrogenase, methanophenazine hydrogenase, methanophenazine-reducing hydrogenase, methylviologen-reducing hydrogenase, Mph-reducing hydrogenase, VhoGAC, VhtGAC, VhxGAC, viologen-reducing hydrogenase
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Substrates Products
Substrates Products on EC 1.12.98.3 - Methanosarcina-phenazine hydrogenase
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REACTION DIAGRAM
2-dihydropentaprenyloxyphenazine
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?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
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no activity with ferredoxin
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?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
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enzyme is part of a membrane-bound electron transport system in methanogenesis
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?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
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-
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?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
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-
-
?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
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-
-
-
?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
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enzyme is part of a membrane-bound electron transport system in methanogenesis
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?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
Q8PU58; F1SVL1; Q8PZ67; F1SVH7; F1SVE4; Q8PU59; Q8PU60; Q8PU61; F1SVE0; F1SVK0; F1SVH9; F1SVL2; F1SVE1
coenzyme F420-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP and diphosphate
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-
?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
Q8PU58; F1SVL1; Q8PZ67; F1SVH7; F1SVE4; Q8PU59; Q8PU60; Q8PU61; F1SVE0; F1SVK0; F1SVH9; F1SVL2; F1SVE1
cofactor F420(H2)-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred
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-
?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
Q8PU58; F1SVL1; Q8PZ67; F1SVH7; F1SVE4; Q8PU59; Q8PU60; Q8PU61; F1SVE0; F1SVK0; F1SVH9; F1SVL2; F1SVE1
coenzyme F420-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred. The electrochemical proton gradient thereby generated drives ATP synthesis from ADP and diphosphate
-
-
?
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
Q8PU58; F1SVL1; Q8PZ67; F1SVH7; F1SVE4; Q8PU59; Q8PU60; Q8PU61; F1SVE0; F1SVK0; F1SVH9; F1SVL2; F1SVE1
cofactor F420(H2)-dependent reduction of 2-hydroxyphenazine as catalyzed by the membrane-bound enzyme is coupled to proton translocation across the cytoplasmic membrane, exhibiting a stoichiometry of 0.9 H+ translocated per two electrons transferred
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?
?
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no growth on H2-CO2, inability to metabolize hydrogen, the lack of hydrogenase activity in Methanosarcina acetivorans extracts is not due to obvious mutations in either the coding regions or the promoters, hydrogenases are inactivated at the level of transcription and/or translation, Methanosarcina acetivorans possesses the machinery to express hydrogenases, although it does not express its own hydrogenases. This is consistent with specific inactivation of the Methanosarcina acetivorans hydrogenase promoters and highlight the importance of testing hypotheses generated by using genomic data
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