4- and 5-methylsalicylate as growth substrates are effectively converted by enzymes of the sal cluster into 4-methylmuconolactone, followed by isomerization to 3-methylmuconolactone. The function of the sal gene cluster is therefore to channel both chloro-substituted and methyl-substituted salicylates into a catechol ortho cleavage pathway, followed by dismantling of the formed substituted muconolactones through specific pathways
the enzyme is part of the chloroaromatic pathway and catalyzes the third step of the cometabolism of 2-chloro-4-methylphenoxyacetate by Alcaligenes eutrophus JMP 134 after growth on 2,4-dichlorophenoxyacetate, overview
the enzyme is part of the chloroaromatic pathway and catalyzes the third step of the cometabolism of 2-chloro-4-methylphenoxyacetate by Alcaligenes eutrophus JMP 134 after growth on 2,4-dichlorophenoxyacetate, overview
the enzyme (ClcA) is recruited in pathways that are involved in the degradation of chlorinated aromatic compounds such as pentachlorophenol. It will also play a role in degradation pathways that produce alkylcatechols. ClcA is involved in pathways that generate catechol as a degradation pathway intermediate
the enzyme (ClcA) is recruited in pathways that are involved in the degradation of chlorinated aromatic compounds such as pentachlorophenol. It will also play a role in degradation pathways that produce alkylcatechols. ClcA is involved in pathways that generate catechol as a degradation pathway intermediate
strain MT1 possesses two catechol 1,2-dioxygenases, encoded by the genes catA and salD, overview. The enzymes differ in their turnover rates for 4-chlorocatechol and especially for 4-methylcatechol, where C12OsalD exhibit significantly higher rates. Both enzymes also differ with respect to their apparent Km values
strain MT1 possesses two catechol 1,2-dioxygenases, encoded by the genes catA and salD, overview. The enzymes differ in their turnover rates for 4-chlorocatechol and especially for 4-methylcatechol, where C12OsalD exhibit significantly higher rates. Both enzymes also differ with respect to their apparent Km values