1.13.11.11: tryptophan 2,3-dioxygenase

This is an abbreviated version!
For detailed information about tryptophan 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.11

1.13.11.11

indoleamine

kynurenine

immunotherapy

heme

serotonin

checkpoint

l-trp

n-formylkynurenine

quinolinic

tolerogenic

3-monooxygenase

3,4-dioxygenase

heme-containing

2,3-dioxygenase-1

tryptophan-degrading

3-hydroxyanthranilate

indoleamine-2,3-dioxygenase

picolinic

tryptophan-catabolizing

pyrrolase

3-hydroxykynurenine

medicine

drug development

Reaction

Synonyms

33737, BRAFLDRAFT_210874, C28H8.11, EC 1.11.1.4, hTDO, IDO-1, IDO-2, IDO1, IDO2, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, TDO, TDO2, TDOa, tryptophan 2,3-dioxygenase, tryptophan 2,3-dioxygenase 2, tryptophan 2,3-dioxygenase-2, tryptophan-2,3-dioxygenase, v1g157887, vCG5163, XcTDO

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.11 tryptophan 2,3-dioxygenase

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Results	in table
2	Activating Compound
9810	AA Sequence
2	Application
14	Cloned(Commentary)
18	Cofactor
4	Crystallization (Commentary)
1191	Disease/ Diagnostics
4	Expression
54	General Information
4	General Stability
135	IC50 Value
146	Inhibitors
26	KM Value [mM]
1	Localization
4	Metals/Ions
3	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
55	Organism
9	Pathway
85	PDB ID
9	pH Optimum
3	Posttranslational Modification
24	Protein Variants
5	Purification (Commentary)
3	Reaction
45	Reference
63	Source Tissue
60	Substrates and Products (Substrate)
9	Subunits
64	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
8	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.13.11.11 - tryptophan 2,3-dioxygenase

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H2O2

Homo sapiens

P14902, P48775, Q6ZQW0

activation of the enzyme is stimulated by superoxide and H2O2

743358

superoxide

Homo sapiens

P14902, P48775, Q6ZQW0

activation of the enzyme is stimulated by superoxide and H2O2

743358