1.13.11.11: tryptophan 2,3-dioxygenase
This is an abbreviated version!
For detailed information about tryptophan 2,3-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.11
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1.13.11.11
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indoleamine
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kynurenine
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immunotherapy
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heme
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serotonin
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checkpoint
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l-trp
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n-formylkynurenine
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quinolinic
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tolerogenic
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3-monooxygenase
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3,4-dioxygenase
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heme-containing
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2,3-dioxygenase-1
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tryptophan-degrading
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3-hydroxyanthranilate
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indoleamine-2,3-dioxygenase
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picolinic
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tryptophan-catabolizing
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pyrrolase
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3-hydroxykynurenine
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medicine
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drug development
- 1.13.11.11
- indoleamine
- kynurenine
-
immunotherapy
- heme
- serotonin
-
checkpoint
- l-trp
- n-formylkynurenine
-
quinolinic
-
tolerogenic
-
3-monooxygenase
-
3,4-dioxygenase
-
heme-containing
-
2,3-dioxygenase-1
-
tryptophan-degrading
- 3-hydroxyanthranilate
- indoleamine-2,3-dioxygenase
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picolinic
-
tryptophan-catabolizing
-
pyrrolase
- 3-hydroxykynurenine
- medicine
- drug development
Reaction
Synonyms
33737, BRAFLDRAFT_210874, C28H8.11, EC 1.11.1.4, hTDO, IDO-1, IDO-2, IDO1, IDO2, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, TDO, TDO2, TDOa, tryptophan 2,3-dioxygenase, tryptophan 2,3-dioxygenase 2, tryptophan 2,3-dioxygenase-2, tryptophan-2,3-dioxygenase, v1g157887, vCG5163, XcTDO
ECTree
1.13.11.11 tryptophan 2,3-dioxygenaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.13.11.11 - tryptophan 2,3-dioxygenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
additional information
expression on brain occurs in different cells as macrophages, microglia, neurons and astrocytes
expression on brain occurs in different cells as macrophages, microglia, neurons and astrocytes
immune cells express high amount of the enzyme (TDO2) at the peak stage of adjuvant-induced arthritis
immune cells express high amount of the enzyme (TDO2) at the peak stage of adjuvant-induced arthritis
the enzyme is located in the oxygene-rich environment of the liver promoting greater amount of the enzyme in ferric form than in ferrous form, which could contribute to the binding to substrates occurs in this form
additional information
in human tumors IDO-2 is expressed, but it is produced in a functionally inactive form
additional information
in human tumors IDO-2 is expressed, but it is produced in a functionally inactive form
additional information
in human tumors IDO-2 is expressed, but it is produced in a functionally inactive form
