1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase

This is an abbreviated version, for detailed information about 4-hydroxyphenylpyruvate dioxygenase, go to the full flat file.

Reaction

4-hydroxyphenylpyruvate
+
O2
=
homogentisate
+
CO2

Synonyms

4-HPPD, 4-hydroxyphenylpyruvare dioxygenase, 4-hydroxyphenylpyruvate dioxygenase, 4-hydroxyphenylpyruvic acid dioxygenase, 4HPPD, At-HPPD, AtHPPD, AvHPPD-03, EC 1.14.2.2, EC 1.99.1.14, formerly, F Alloantigen, F protein, F-antigen homolog, HPD, hpdA, HPPD, HPPDase, Legiolysin, MsHPPD, oxygenase, 4-hydroxyphenylpyruvate di-, p-hydroxyphenyl pyruvate dioxygenase, p-hydroxyphenylpyruvate dioxygenase, p-hydroxyphenylpyruvate hydroxylase, p-hydroxyphenylpyruvate oxidase, p-hydroxyphenylpyruvic acid hydroxylase, p-hydroxyphenylpyruvic hydroxylase, p-hydroxyphenylpyruvic oxidase, PTO1369, Pt_Hpd, T-cell reactive protein, TF-AG, YS103B

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.27 4-hydroxyphenylpyruvate dioxygenase

Specific Activity

Specific Activity on EC 1.13.11.27 - 4-hydroxyphenylpyruvate dioxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.004
protein expressed in Escherichia coli DH5alpha
0.04
-
purified recombinant mutant R378K, pH 6.5, 37C, homogentisate production
0.06
-
purified recombinant mutant E254D, pH 6.5, 37C, O2 consumption
0.07
-
purified recombinant mutant R378K, pH 6.5, 37C, O2 consumption
0.11 - 0.2
protein expressed in Escherichia coli SG13009
0.17 - 0.26
protein expressed in Escherichia coli M15(pRep4)
0.2
-
purified recombinant mutant E254D, pH 6.5, 37C, homogentisate production
0.51 - 1.1
-
enzyme forms 1, 2, and 3
0.53
-
-
0.6 - 0.9
-
-
2.6
-
purified recombinant wild-type enzyme, pH 6.5, 37C, O2 consumption
2.8
-
purified recombinant wild-type enzyme, pH 6.5, 37C, homogentisate production
10.6
-
pH 7.0, 25C
39.6
-
-
additional information