1.13.11.3: protocatechuate 3,4-dioxygenase

This is an abbreviated version!
For detailed information about protocatechuate 3,4-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.3

Reaction

3,4-dihydroxybenzoate
+
O2
=
3-carboxy-cis,cis-muconate

Synonyms

3,4-PCase, 3,4-PCD, 3,4-PCDase, 3,4-POD, EC 1.13.1.3, EC 1.99.2.3, More, oxygenase, protocatechuate 3,4-di-, P3,4DO, P3,4O enzyme, P34O, PCA 3,4-dioxygenase, PcaG, PcaH, PcaHG, protocatchetuate 3,4-dioxygenase, protocatechuate 3,4-dioxygenase, protocatechuate oxygenase, protocatechuic 3,4-dioxygenase, protocatechuic 3,4-oxygenase, protocatechuic acid oxidase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.3 protocatechuate 3,4-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.3 - protocatechuate 3,4-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-3-(3,4-dimethoxyphenyl)-N-hydroxyprop-2-enamide
over 90% inhibition at 0.2 mM
(2E)-N-hydroxy-3-(4-methoxyphenyl)prop-2-enamide
over 90% inhibition at 0.2 mM
1,10-phenanthroline
-
0.005 mM, approx. 50% inhibition after 30 min, complete inhibition after 60 min, complete restoration of inactivated enzyme by addition of excess ferric EDTA complex
2,2'-dipyridyl
2,3-Dihydroxybenzoate
2,4-dihydroxybenzoic acid
-
competitive inhibition
2,5-Dihydroxybenzoate
-
-
2-(2H-1,3-benzodioxol-5-yl)-N-[(4-fluorophenyl)methyl]-N-hydroxyacetamide
60% inhibition at 0.2 mM
2-Fluoro-4-hydroxybenzoate
-
-
2-Hydroxyisonicotinic acid N-oxide
2-Hydroxypyridine N-oxide
-
-
3,4-Dihydroxyacetophenone
3,4-dihydroxybenzoate
-
-
3,4-dihydroxycinnamic acid
-
-
3,4-Dihydroxyphenylacetate
-
-
3,4-dihydroxyphenylacetic acid
3,4-Dihydroxyphenylpropionate
-
-
3,5-Dichloro-4-hydroxybenzoate
-
-
3-(3,4-dimethoxyphenyl)-N-hydroxy-N-octylpropanamide
57% inhibition at 0.2 mM
3-(3,4-dimethoxyphenyl)-N-hydroxypropanamide
60% inhibition at 0.2 mM
3-Bromo-4-hydroxybenzoate
-
-
3-Chloro-4-hydroxybenzoate
-
-
3-Fluoro-4-hydroxybenzoate
3-hydroxybenzoate
3-hydroxyphenylacetic acid
-
-
3-Nitrophenol
-
0.006 mM, 56% inhibition
4-(dimethylamino)benzaldehyde
-
-
4-Fluoro-3-hydroxybenzoate
4-hydroxybenzoate
4-hydroxymercuribenzoate
4-hydroxyphenylacetic acid
-
-
4-methylcatechol
4-nitrocatechol
4-sulfocatechol
alpha-chloro-3,4-dihydroxyacetophenone
-
-
butanol
Ca2+
Nocardia erythropolis
-
-
caffeic acid
-
-
catechol
ethanol
Ferrous ammonium sulfate
-
-
Hg2+
Nocardia erythropolis
-
0.1 mM, 45% inhibition
iodoacetate
isonicotinic acid N-oxide
-
-
Isovanillate
-
-
K+
16.7% residual activity at 1 mM
KF
-
50 mM, 34% inhibition
methanol
Mg2+
50% residual activity at 1 mM
N-ethylmaleimide
Na2HAsO4
Nocardia erythropolis
-
0.1 mM, 50% inhibition
Nickel ammonium sulfate
-
-
o-Chloranil
-
0.006 mM, 51% inhibition
p-chloromercuribenzoate
-
0.05 mM, 47% inhibition
Pb2+
Nocardia erythropolis
-
-
Phenanthroline
Propanol
Protocatechualdehyde
protocatechuate
Protocatechuic acid methyl ester
-
-
vanillate
-
-
additional information
-