arachidonate 12-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 12-lipoxygenase, go to the full flat file.

Word Map on EC




(12R)-lipoxygenase, (12R)-LOX, 11R-lipoxygenase, 11R-LOX, 12(R)-lipoxygenase, 12(S)-lipoxygenase, 12-hLO, 12-lipoxygenase, 12-LO, 12-LOX, 12/15 lipoxygenase, 12/15-lipoxygenase, 12/15-lipoxygenases, 12/15-LO, 12/15-LOX, 12/15LO, 12DELTA-lipoxygenase, 12LO, 12R-lipoxygenase, 12R-LOX, 12R-LOX-2, 12S-lipoxygenase, 15-lipoxygenase, 15-LO, 2-lipoxygenase, 2/15-lipoxygenase, ALOX 12, ALOX 12/15, ALOX12, Alox12b, Alox15, ALOX15B, ALOX5, arachidonate 12/15-lipoxygenase, C-12 lipoxygenase, cardiac 12/15-LOX, DELTA 12-lipoxygenase, epidermal-type lipoxygenase, hp-12LOX, human platelet 12-lipoxygenase, leukocyte-type 12-lipoxygenase, leukocyte-type 12-LOX, leukocyte-type 12/15-lipoxygenase, leukocyte-type lipoxygenase, leukotriene A4 synthase M, lipoxygenase 12, LOX, LOX-12, LTA4 synthase, oxylipin-producing enzyme, oygenase, arachidonate 12-lip-, P-12LOX, p12-LO, p12-LOX, platelet 12-lipoxygenase, platelet-type 12(S)-lipoxygenase, platelet-type 12-human lipoxygenase, platelet-type 12-lipoxygenase, platelet-type 12-LOX, platelet-type 12LO, Platelet-type lipoxygenase 12, zf12-LOX


     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
       arachidonate 12-lipoxygenase


Expression on EC - arachidonate 12-lipoxygenase

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12/15-LO is upregulated in white adipose tissue in the obese state. The potent vasoconstricting and pro-inflammatory hormone angiotensin II (Ang II) led to increases in leukocyte-type 12-LO mRNA and protein levels, as well as increased enzyme activity
12/15-LOX activity is enhanced during chronic, but not acute, toxoplasmosis
12/15-LOX is markedly upregulated in heart failure, cardiac expression is upregulated during pressure overload
12/15-LOX mRNA expression in cultured aortic smooth muscle cells is upregulated by angiotensin II, ATII. ATII also stimulates production of LOX-derived HETEs in arterial vessels and the kidney
ALOX12 expression and its metabolite 12(S)-hydroxyeicosatetraenoic acid are significantly increased in the visceral adipose tissue of type 2 diabetes subjects with body mass index of 21. ALOX12 expression positively correlated with expression of inflammatory genes encoding IL-6, IL-12a, CXCL10, and lipocalin-2
an increase of ALOX15B expression during the differentiation of monocytes to macrophages is shown. Stimulation of macrophages with a set of cytokines and with hypoxia reveals that IL-4, IL-13, LPS and hypoxia further increase the ALOX15B mRNA
ceramide increases mRNA and protein expression, and activity of 12-LOX
expression of 12/15-LOX pathway is upregulated in the diabetic heart
expression of ALOX12 remains on the same level during differentiation from monocyte to macrophage
insulin-like growth factor II induces 12-LOX expression and blocks cell cycle progression
level of 12-LOX expression is dose-dependently decreased by UVB and UVA-irradiation. Successful psoralen plus ultraviolet A, UVA-photochemotherapy-mediated inhibition of cell growth and inflammation via decreased 12-LOX expression. 15(S)-hydroxyeicosatetraenoic acid, 15-HETrE and 13(S)-hydroxyoctadecadienoic acid (15-LOX metabolites) significantly inhibit insulin-like growth factor II-induced 12-LOX expression
reduced monocyte chemoattractant protein-1 expression in mouse peritoneal macrophages from 12/15-LO null mice
siRNA decreases 12-LOX protein expression and hydroxyl radical signals occur in a 12-LOX small interfering RNA knockdown protein group compared with the baicalein control
strong expression of 12/15-LO in inflammatory synovial tissue
tumor necrosis factor-alpha induces p12-LOX in the early stage of tumorigenesis, induces p12-LOX expression both in JB6P+ and JB6P- cells