1.13.11.31: arachidonate 12-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 12-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.31

Reaction

arachidonate
+
O2
=
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate

Synonyms

(12R)-lipoxygenase, (12R)-LOX, 11R-lipoxygenase, 11R-LOX, 12(R)-lipoxygenase, 12(S)-lipoxygenase, 12-hLO, 12-lipoxygenase, 12-LO, 12-LOX, 12/15 lipoxygenase, 12/15-lipoxygenase, 12/15-lipoxygenases, 12/15-LO, 12/15-LOX, 12/15LO, 12DELTA-lipoxygenase, 12LO, 12R-lipoxygenase, 12R-LOX, 12R-LOX-2, 12S-lipoxygenase, 15-lipoxygenase, 15-LO, 2-lipoxygenase, 2/15-lipoxygenase, ALOX 12, ALOX 12/15, ALOX12, Alox12b, Alox15, ALOX15B, ALOX5, arachidonate 12/15-lipoxygenase, C-12 lipoxygenase, cardiac 12/15-LOX, DELTA 12-lipoxygenase, epidermal-type lipoxygenase, hp-12LOX, human platelet 12-lipoxygenase, leukocyte-type 12-lipoxygenase, leukocyte-type 12-LOX, leukocyte-type 12/15-lipoxygenase, leukocyte-type lipoxygenase, leukotriene A4 synthase M, lipoxygenase 12, LOX, LOX-12, LTA4 synthase, oxylipin-producing enzyme, oygenase, arachidonate 12-lip-, P-12LOX, p12-LO, p12-LOX, platelet 12-lipoxygenase, platelet-type 12(S)-lipoxygenase, platelet-type 12-human lipoxygenase, platelet-type 12-lipoxygenase, platelet-type 12-LOX, platelet-type 12LO, Platelet-type lipoxygenase 12, zf12-LOX

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.31 arachidonate 12-lipoxygenase

IC50 Value

IC50 Value on EC 1.13.11.31 - arachidonate 12-lipoxygenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0007
(2E,5E)-7-hydroperoxy-3,7-dimethyl-2,5-octa-dienyl-O-(alpha-L-rhamnopyranosyl)-(1''->3')-(4'''-O-cis-p-coumaroyl)-beta-D-glucopyranoside
Sus scrofa
pH 7.4, 30°C, recombinant leukocyte-type enzyme
0.0017
(2E,5E)-7-hydroperoxy-3,7-dimethyl-2,5-octadienyl-O-(alpha-L-rhamnopyranosyl)-(1''->3')-(4'''-O-trans-p-coumaroyl)-beta-D-glucopyranoside
Sus scrofa
pH 7.4, 30°C, recombinant leukocyte-type enzyme
0.0007
2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol
Homo sapiens
-
IC50: 0.0007 mM
0.0041
2,3,4,5-tetrabromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol
Homo sapiens
-
IC50: 0.0041 mM
0.00041
2,3,5-tribromo-6-(4,5-dibromo-2-hydroxyphenoxy)phenol
Homo sapiens
-
IC50: 0.00041 mM
0.012
2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol
Homo sapiens
-
IC50: 0.012 mM
0.007
2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol
Homo sapiens
-
IC50: 0.007 mM
0.00078
3'-chloro-7,8-dihydroxyisoflavone
Homo sapiens
-
pH 7.5, 22°C
0.0075
3,15-dihydroxy-8,11,13-eicosatrienoic acid
Homo sapiens
-
IC50: 0.0075 mM
0.05
3,4,6,8-tetrabromooxanthren-1-ol
Homo sapiens
-
IC50: 0.05 mM
0.006
3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol
Homo sapiens
-
IC50: 0.006 mM
0.047
3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol
Homo sapiens
-
IC50: 0.047 mM
0.03
3,6,8-tribromooxanthren-1-ol
Homo sapiens
-
IC50: 0.03 mM
0.0004
3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide
Homo sapiens
-
IC50: 0.0004 mM
0.017
4',6,7-trihydroxyisoflavan
Homo sapiens
-
pH 7.5, 22°C
0.0038
4',6,7-trihydroxyisoflavanone
Homo sapiens
-
pH 7.5, 22°C
0.0087
4',6,7-trihydroxyisoflavone
Homo sapiens
-
pH 7.5, 22°C
0.00048
4'-chloro-7,8-dihydroxyisoflavone
Homo sapiens
-
pH 7.5, 22°C
0.0081
4,15-dihydroxy-5,8,11,13-eicosatetraenoic acid
Homo sapiens
-
IC50: 0.0081 mM
0.01
4,4'-propane-2,2-diylbis(2,6-dibromophenol)
Homo sapiens
-
IC50: 0.01 mM
0.0008
5,15-dihydroxy-5,8,11,13,17-eicosapentaenoic acid
Homo sapiens
-
IC50: 0.0008 mM
0.00006
5,8,11,14-Eicosatetraynoic acid
Sus scrofa
-
IC50: 0.00006 mM
0.0004
6,17-dihydroxy-4,7,10,13,15,19-eicosahexaenoic acid
Homo sapiens
-
IC50: 0.0004 mM
0.011
6,7-dihydroxy-3',4'-methylenedioxyisoflavan
Homo sapiens
-
pH 7.5, 22°C
0.1
6,7-dihydroxy-3',4'-methylenedioxyisoflavone
Homo sapiens
-
above, pH 7.5, 22°C
0.015
6,7-dihydroxy-3'-methylisoflavan
Homo sapiens
-
pH 7.5, 22°C
0.014
6,7-dihydroxy-3'-methylisoflavanone
Homo sapiens
-
pH 7.5, 22°C
0.0076
6,7-dihydroxy-4'-methoxyisoflavan
Homo sapiens
-
pH 7.5, 22°C
0.0016
6,7-dihydroxy-4'-methoxyisoflavanone
Homo sapiens
-
pH 7.5, 22°C
0.1
6,7-dihydroxy-4'-methoxyisoflavone
Homo sapiens
-
above, pH 7.5, 22°C
0.0058
6,7-dihydroxy-4'-nitroisoflavone
Homo sapiens
-
pH 7.5, 22°C
0.1
7,8-dihydroxy-3',4'-dimethoxyisoflavan
Homo sapiens
-
above, pH 7.5, 22°C
0.0036
7,8-dihydroxy-3'-methylisoflavone
Homo sapiens
-
pH 7.5, 22°C
0.00062
7,8-dihydroxy-3'-trifluoromethylisoflavone
Homo sapiens
-
pH 7.5, 22°C
0.026
7,8-dihydroxy-4'-methoxyisoflavan
Homo sapiens
-
pH 7.5, 22°C
0.07
7,8-dihydroxy-4'-methylisoflavan
Homo sapiens
-
pH 7.5, 22°C
0.0016
7,8-dihydroxy-4'-methylisoflavone
Homo sapiens
-
pH 7.5, 22°C
0.0064
7,8-dihydroxyisoflavone
Homo sapiens
-
pH 7.5, 22°C
0.00058
alpha-mangostin
Homo sapiens
pH 8.0, recombinant enzyme
0.0023
bestatin 7
Homo sapiens
-
IC50: 0.0023 mM
0.009
dysidenin
Homo sapiens
above, pH 8.0, recombinant enzyme
0.0049
michellamine B
Homo sapiens
pH 8.0, recombinant enzyme
0.075
N-([5-chloro-2-(dimethylamino)-8-hydroxyquinolin-7-yl](furan-2-yl)methyl)acetamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.075
N-([5-chloro-8-hydroxy-2-(piperidin-1-yl)quinolin-7-yl](furan-2-yl)methyl)acetamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.075
N-[(2,5-dichloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]acetamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.075
N-[(4-chloro-1-hydroxynaphthalen-2-yl)(furan-2-yl)methyl]acetamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.002
N-[(5-bromo-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.002
N-[(5-bromo-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.001
N-[(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.014
N-[(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.075
N-[(5-bromofuran-2-yl)(5-chloro-8-hydroxyquinolin-7-yl)methyl]propanamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.003
N-[(5-chloro-8-hydroxy-1,2,3,4,4a,8a-hexahydroquinolin-7-yl)(furan-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.05
N-[(5-chloro-8-hydroxyquinolin-7-yl)(4-fluorophenyl)methyl]propanamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.15
N-[(5-chloro-8-hydroxyquinolin-7-yl)(4-methylphenyl)methyl]propanamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.0035
N-[(5-chloro-8-hydroxyquinolin-7-yl)(5-methylthiophen-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.003
N-[(5-chloro-8-hydroxyquinolin-7-yl)(cyclopropyl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.0016
N-[(5-chloro-8-hydroxyquinolin-7-yl)(cyclopropyl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.025
N-[(5-chloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]-4-methylbenzamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.003
N-[(5-chloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.025
N-[(5-chloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]benzamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.001
N-[(5-chloro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.001
N-[(5-chloro-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.001
N-[(5-chloro-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.15
N-[(5-chloro-8-hydroxyquinolin-7-yl)methyl]acetamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.075
N-[(5-chloro-8-methoxyquinolin-7-yl)(furan-2-yl)methyl]propanamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.005
N-[(5-fluoro-8-hydroxyquinolin-7-yl)(furan-2-yl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.002
N-[(5-fluoro-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.0008
N-[(8-hydroxy-5-nitroquinolin-7-yl)(thiophen-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.0034
N-[(8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.025
N-[(R)-(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.025
N-[(R)-(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.00043
N-[(S)-(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.00038
N-[(S)-(5-bromo-8-hydroxyquinolin-7-yl)(thiophen-2-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.0026
N-[1-(5-chloro-8-hydroxyquinolin-7-yl)-2-methylpropyl]acetamide
Homo sapiens
-
pH 8.0, 23°C
0.0012
N-[1-(5-chloro-8-hydroxyquinolin-7-yl)-2-methylpropyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.15
N-[1-(5-chloro-8-hydroxyquinolin-7-yl)ethyl]acetamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.05
N-[1-(5-chloro-8-hydroxyquinolin-7-yl)ethyl]propanamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.075
N-[1-(5-fluoro-8-hydroxyquinolin-7-yl)ethyl]acetamide
Homo sapiens
-
value above, pH 8.0, 23°C
0.0012
N-[furan-2-yl(8-hydroxy-5-nitroquinolin-7-yl)methyl]propanamide
Homo sapiens
-
pH 8.0, 23°C
0.1
neodysidenin
Homo sapiens
above, pH 8.0, recombinant enzyme
0.0022 - 0.0051
nordihydroguaiaretic acid
0.00021
NSC172033
Homo sapiens
pH 8.0, recombinant enzyme
0.00015
NSC292213
Homo sapiens
pH 8.0, recombinant enzyme
0.00019
NSC617570
Homo sapiens
pH 8.0, recombinant enzyme
0.00044
quercetin
Homo sapiens
-
pH and temperature not specified in the publication