1.13.11.34: arachidonate 5-lipoxygenase
This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.34
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1.13.11.34
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cyclooxygenase
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prostaglandin
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leukocyte
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neutrophil
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eicosanoids
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cox-2
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asthma
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indomethacin
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ionophore
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phospholipase
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zileuton
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polymorphonuclear
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thromboxane
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flap
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airway
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peritoneal
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5-hete
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platelet
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eosinophil
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mast
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cysteinyl
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allergic
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edema
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12-lipoxygenase
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histamine
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lta4
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nordihydroguaiaretic
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lipoxygenases
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paf
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ndga
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bronchoconstriction
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5-hydroxyeicosatetraenoic
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asthmatic
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basophil
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platelet-activating
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anaphylaxis
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zymosan
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antigen-induced
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lipoxins
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montelukast
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hetes
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mpges-1
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carrageenan-induced
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a23187-stimulated
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paf-induced
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pro-resolving
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synthesis
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bronchospasm
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medicine
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drug development
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14carachidonic
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pharmacology
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bronchoconstrictors
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ulcerogenic
- 1.13.11.34
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cyclooxygenase
- prostaglandin
- leukocyte
- neutrophil
-
eicosanoids
- cox-2
- asthma
- indomethacin
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ionophore
- phospholipase
- zileuton
-
polymorphonuclear
-
thromboxane
- flap
- airway
- peritoneal
-
5-hete
- platelet
-
eosinophil
-
mast
-
cysteinyl
-
allergic
- edema
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12-lipoxygenase
- histamine
- lta4
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nordihydroguaiaretic
- lipoxygenases
- paf
- ndga
-
bronchoconstriction
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5-hydroxyeicosatetraenoic
-
asthmatic
-
basophil
-
platelet-activating
- anaphylaxis
- zymosan
-
antigen-induced
-
lipoxins
- montelukast
-
hetes
- mpges-1
-
carrageenan-induced
-
a23187-stimulated
-
paf-induced
-
pro-resolving
- synthesis
- bronchospasm
- medicine
- drug development
-
14carachidonic
- pharmacology
-
bronchoconstrictors
-
ulcerogenic
Reaction
Synonyms
5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase
ECTree
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Source Tissue
Source Tissue on EC 1.13.11.34 - arachidonate 5-lipoxygenase
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induced by a Ca2+ ionophore, from acute myeloid leukemic and acute lymphoid leukemic patients, upregulation of the enzyme, quantitative expression analysis
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expression is not significantly different between diabetic and control rats. Activation of the 5-lipoxygenase previously reported in streptozotocin-induced diabetic rats can be explained by an augmented sensitivity to cysteinyl leukotrienes in the diabetic aorta
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in healthy animals, 5-LOX expression is almost exclusively limited to the bronchiolar epithelial cells, while Metastrongylus spp.-parasitized pigs have greater 5-LOX-specific immunoreactivity involving a wide range of cell types within foci of granulomatous and eosinophilic bronchopneumonia
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normal skin keratinocytes and a cell line of human keratinocytes, HaCaT
high expression level. In the kidney, the expression levels of Alox5 of fish fed diets with low dietary linolenic acid/linoleic acid (0.03-0.06) are significantly higher than those of fish fed diets with high dietary linolenic acid/linoleic acid (0.45-1.51)
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high expression of 5-lipoxygenase in mantle zone B cells from tonsils, weak expression in germinal centre cells and no expression in plasma cells from tonsils. High expression in mantle B cell lymphoma and weak or no expression in follicular lymphoma. Primary leukemized mantle B cell lymphoma (B-prolymphocytic leukaemia cells) and mantle B cell lymphoma cell lines also expressed 5-lipoxygenase
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5-lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells, overview
additional information
of young and old mice, comparison of enzyme expression and activity in brain regions, e.g. cortex, hippocampus and cerebellum, overview
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of young and old mice, comparison of enzyme expression and activity in brain regions, e.g. cortex, hippocampus and cerebellum, overview
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of diverse tissues, e.g. colon, lung breast, prostate, pancreas, bone, brain, and mesothelial cancer cells
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high level of expression, colocalization of 5-lipoxygenase and 5-lipoxygenase-activating protein in CA1 pyramidal neurons
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the 5-lipoxygenase core promoter is unmethylated, expression of 5-lipoxygenase protein upon differentiation
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in the liver, the Alox5 mRNA expression levels significantly increase to the maximum when the dietary linolenic acid/linoleic acid increases from 0.03 to 0.06, and then significantly decreases with dietary linolenic acid/linoleic acid increased to 1.51
increased enzyme activity in obese mice compared to twild-type mice, overview
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increased enzyme activity in obese mice compared to twild-type mice, overview
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constitutive production of 5-hydroxyeicosatetraenoic acid
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retinal blood vessels of wild-type and mutant mice, diabetic mice show increased expression of leukotriene B4 receptors
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retinal blood vessels of wild-type and mutant mice, diabetic mice show increased expression of leukotriene B4 receptors
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peripheral cells, including CD4, CD8, CD45RO, CD45RA, T helper type 2, T-cell receptor-alphabeta and -gammadelta expressing cells
expression of 5-LO is much higher in differentiated myeloid cells and cell lines than in undifferentiated cells, cell lines HeLa, U-937 and HL-60TB do not express 5-LO protein
additional information
5-LO is mainly expressed in polymorphonuclear leukocytes, monocytes/macrophages, dendritic cells, mast cells and B cells
additional information
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5-LO is mainly expressed in polymorphonuclear leukocytes, monocytes/macrophages, dendritic cells, mast cells and B cells
additional information
expression of wild-type 5-LO and particularly of the 5-LODELTA13 and 5-LOp12 mutant isoforms is increased in monocytes from patients with rheumatoid arthritis and sepsis
additional information
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expression of wild-type 5-LO and particularly of the 5-LODELTA13 and 5-LOp12 mutant isoforms is increased in monocytes from patients with rheumatoid arthritis and sepsis