1.13.11.40: arachidonate 8-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 8-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.40

1.13.11.40

lipoxygenases

coral

allene

plexaura

homomalla

8r-hpete

epidermis-type

whip

12r-lox

8-hydroxyeicosatetraenoic

medicine

Reaction

Synonyms

8(R)-lipoxygenase, 8-lipoxygenase, 8-LOX, 8R-lipoxygenase, 8R-LOX, 8S-lipoxygenase, 8S-LOX, allene oxide synthase-lipoxygenase protein, arachidonic acid C-8 lipoxygenase, eicosapentaenoic 8R-lipoxygenase, LOX-1, More

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.40 arachidonate 8-lipoxygenase

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All data fields related to EC 1.13.11.40
Results	in table
2	Activating Compound
7	AA Sequence
2	Application
1	CAS Registry Number
11	Cloned(Commentary)
5	Crystallization (Commentary)
4	General Information
2	General Stability
7	Inhibitors
4	kcat/KM [mM/s]
17	KM Value [mM]
3	Localization
4	Metals/Ions
2	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
22	Organism
4	Pathway
20	PDB ID
5	pH Optimum
1	pH Range
1	Posttranslational Modification
26	Protein Variants
9	Purification (Commentary)
1	Reaction
4	Reaction Type
22	Reference
7	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
51	Substrates and Products (Substrate)
2	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Turnover Number [1/s]

KM Value

KM Value on EC 1.13.11.40 - arachidonate 8-lipoxygenase

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0.039

(15S)-hydroperoxyeicosatetraenoic acid

Mus musculus

in 50 mM sodium phosphate buffer, pH 7.4, at 25°C

671715

0.015

(15S)-hydroxyeicosatetraenoic acid

Mus musculus

in 50 mM sodium phosphate buffer, pH 7.4, at 25°C

671715

0.0021

(8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid

Mus musculus

in 50 mM sodium phosphate buffer, pH 7.4, at 25°C

671715

0.0057

(8S)-hydroxyeicosatetraenoic acid

Mus musculus

in 50 mM sodium phosphate buffer, pH 7.4, at 25°C

671715

0.008 - 0.135

arachidonate

10 entries

0.0012 - 0.008

arachidonic acid

2 entries

additional information

Plexaura homomalla

O16025

substrate inhibition steady state kinetics

742865