1.13.11.40: arachidonate 8-lipoxygenase
This is an abbreviated version!
For detailed information about arachidonate 8-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.40
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1.13.11.40
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lipoxygenases
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coral
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allene
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plexaura
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homomalla
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8r-hpete
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epidermis-type
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whip
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12r-lox
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8-hydroxyeicosatetraenoic
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medicine
- 1.13.11.40
- lipoxygenases
-
coral
-
allene
-
plexaura
- homomalla
-
8r-hpete
-
epidermis-type
-
whip
- 12r-lox
-
8-hydroxyeicosatetraenoic
- medicine
Reaction
Synonyms
8(R)-lipoxygenase, 8-lipoxygenase, 8-LOX, 8R-lipoxygenase, 8R-LOX, 8S-lipoxygenase, 8S-LOX, allene oxide synthase-lipoxygenase protein, arachidonic acid C-8 lipoxygenase, eicosapentaenoic 8R-lipoxygenase, LOX-1, More
ECTree
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Reference on EC 1.13.11.40 - arachidonate 8-lipoxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bundy, G.L.; Nidy, E.G.; Epps, D.E.; Mizsak, S.A.; Wnuk, R.J.
Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian coral Pseudoplexaura porosa
J. Biol. Chem.
261
747-751
1986
Pseudoplexaura porosa
Brash, A.R.; Baertschi, S.W.; Ingram, C.D.; Harris, T.M.
On non-cyclooxygenase prostaglandin synthesis in the sea whip coral, Plexaura homomalla: an 8(R)-lipoxygenase pathway leads to formation of an alpha-ketol and a Racemic prostanoid
J. Biol. Chem.
262
15829-15839
1987
Plexaura homomalla
Fuerstenberger, G.; Hagedorn, H.; Jacobi, T.; Besemfelder, E.; Stephan, M.; Lehman, W.D.; Marks, F.
Characterization of an 8-lipoxygenase activity induced by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin in vivo
J. Biol. Chem.
266
15738-15745
1991
Mus musculus
Brash, A.R.; Boeglin, W.E.; Chang, M.S.; Shieh, B.H.
Purification and molecular cloning of an 8R-lipoxygenase from the coral Plexaura homomalla reveal the related primary structures of R- and S-lipoxygenases
J. Biol. Chem.
271
20949-20957
1996
Asteroidea, Callista chione, Plexaura homomalla, Strongylocentrotus purpuratus
Steel, D.J.; Tieman, T.L.; Schwartz, J.H.; Feinmark, S.L.
Identification of an 8-lipoxygenase pathway in nervous tissue of Aplysia californica
J. Biol. Chem.
272
18673-18681
1997
Aplysia californica
Qiao, N.; Takahashi, Y.; Takamatsu, H.; Yoshimoto, T.
Leukotriene A synthase activity of purified mouse skin arachidonate 8-lipoxygenase expressed in Escherichia coli
Biochim. Biophys. Acta
1438
131-139
1999
Mus musculus
Schneider, C.; Strayhorn, W.D.; Brantley, D.M.; Nanney, L.B.; Yull, F.E.; Brash, A.R.
Upregulation of 8-lipoxygenase in the dermatitis of IkB-a-deficient mice
J. Invest. Dermatol.
122
691-698
2004
Mus musculus
Coffa, G.; Brash, A.R.
A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation
Proc. Natl. Acad. Sci. USA
101
15579-15584
2004
Plexaura homomalla
Jisaka, M.; Iwanaga, C.; Takahashi, N.; Goto, T.; Kawada, T.; Yamamoto, T.; Ikeda, I.; Nishimura, K.; Nagaya, T.; Fushiki, T.; Yokota, K.
Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist
Biochem. Biophys. Res. Commun.
338
136-143
2005
Mus musculus
Oldham, M.L.; Brash, A.R.; Newcomer, M.E.
Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality
J. Biol. Chem.
280
39545-39552
2005
Plexaura homomalla
Schweiger, D.; Fuerstenberger, G.; Krieg, P.
Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways
J. Lipid Res.
48
553-564
2007
Mus musculus
Neau, D.B.; Gilbert, N.C.; Bartlett, S.G.; Boeglin, W.; Brash, A.R.; Newcomer, M.E.
The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity
Biochemistry
48
7906-7915
2009
Plexaura homomalla (O16025), Plexaura homomalla
Walther, M.; Roffeis, J.; Jansen, C.; Anton, M.; Ivanov, I.; Kuhn, H.
Structural basis for pH-dependent alterations of reaction specificity of vertebrate lipoxygenase isoforms
Biochim. Biophys. Acta
1791
827-835
2009
Mus musculus
Saura, P.; Suardiaz, R.; Masgrau, L.; Gonzalez-Lafont, A.; Rosta, E.; Lluch, J.
Understanding the molecular mechanism of the Ala-versus-Gly concept controlling the product specificity in reactions catalyzed by lipoxygenases a combined molecular dynamics and QM/MM study of coral 8R-lipoxygenase
ACS Catal.
7
4854-4866
2017
Plexaura homomalla
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Neau, D.B.; Bender, G.; Boeglin, W.E.; Bartlett, S.G.; Brash, A.R.; Newcomer, M.E.
Crystal structure of a lipoxygenase in complex with substrate the arachidonic acid-binding site of 8R-lipoxygenase
J. Biol. Chem.
289
31905-31913
2014
Plexaura homomalla (O16025)
Mishra, V.K.; Mishra, S.
Origin of regio- and stereospecific catalysis by 8-lipoxygenase
J. Phys. Chem. B
123
10605-10621
2019
Plexaura homomalla (O16025)
Gilbert, N.C.; Neau, D.B.; Newcomer, M.E.
Expression of an 8R-lipoxygenase from the coral Plexaura homomalla
Methods Enzymol.
605
33-49
2018
Plexaura homomalla (Q27901), Plexaura homomalla
Mishra, V.K.; Mishra, S.
Flipped regiospecificity in L434F mutant of 8-lipoxygenase
Phys. Chem. Chem. Phys.
22
16013-16022
2020
Plexaura homomalla (O16025)
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