1.13.11.40: arachidonate 8-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 8-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.40

1.13.11.40

lipoxygenases

coral

allene

plexaura

homomalla

8r-hpete

epidermis-type

whip

12r-lox

8-hydroxyeicosatetraenoic

medicine

Reaction

Synonyms

8(R)-lipoxygenase, 8-lipoxygenase, 8-LOX, 8R-lipoxygenase, 8R-LOX, 8S-lipoxygenase, 8S-LOX, allene oxide synthase-lipoxygenase protein, arachidonic acid C-8 lipoxygenase, eicosapentaenoic 8R-lipoxygenase, LOX-1, More

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.40 arachidonate 8-lipoxygenase

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All data fields related to EC 1.13.11.40
Results	in table
2	Activating Compound
7	AA Sequence
2	Application
1	CAS Registry Number
11	Cloned(Commentary)
5	Crystallization (Commentary)
4	General Information
2	General Stability
7	Inhibitors
4	kcat/KM [mM/s]
17	KM Value [mM]
3	Localization
4	Metals/Ions
2	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
22	Organism
4	Pathway
20	PDB ID
5	pH Optimum
1	pH Range
1	Posttranslational Modification
26	Protein Variants
9	Purification (Commentary)
1	Reaction
4	Reaction Type
22	Reference
7	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
51	Substrates and Products (Substrate)
2	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
17	Turnover Number [1/s]

Substrates Products

Substrates Products on EC 1.13.11.40 - arachidonate 8-lipoxygenase

for references in articles please use BRENDA:EC1.13.11.40

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(15S)-hydroperoxyeicosatetraenoic acid + O2

Mus musculus

671715

Substrates: -
Products: -

(15S)-hydroxyeicosatetraenoic acid + O2

Mus musculus

671715

Substrates: -
Products: -

(5Z,8Z,11Z,14Z)-nonadeca-5,8,11,14-tetraene-1,19-dioic acid + O2

Mus musculus

702435

Substrates: 8-LOX tolerates a carboxylic group in the substrate-binding pocket
Products: -

(8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid + O2

(8S,15S)-dihydroperoxy-5Z,9E,11Z,13E-eicosatetraenoic acid

Mus musculus

671715

Substrates: -
Products: -

(8S)-hydroxyeicosatetraenoic acid + O2

Mus musculus

671715

Substrates: -
Products: -

17S-hydroxy-docosa-4Z,7Z,10Z,13Z,15E,19Z-hexaenoic acid + O2

10R,17S-dihydroxy-docosa-4Z,7Z,11E,13Z,15E,19Z-hexaenoic acid

Euphausia pacifica

A0A7G1H6X8

765778

Substrates: -
Products: -

2 arachidonic acid + 2 O2

8-hydroxy,9-oxo-eicosa-5Z,11Z,14Z-trienoic acid + 9-oxo-[8,12-cis]-prosta-5Z,10,14Z-trienoic acid + H2O

9 entries

5-hydroperoxy fatty acid + O2

leukotriene A4

Mus musculus

439401

Substrates: leukotriene A synthase activity, reaction rate is approximately 7% of arachidonate 8-lipoxygenation
Products: -

5-hydroperoxyeicosatetraenoic acid + ?

leukotriene A4

Mus musculus

439401

Substrates: -
Products: unstable product

alpha-linolenic acid + O2

Mus musculus

439401

Substrates: -
Products: -

arachidonate + O2

(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate

4 entries

arachidonate + O2

(5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate

Plexaura homomalla

660365

Substrates: -
Products: -

arachidonate + O2

(5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyicosa-5,9,11,14-tetraenoate

Plexaura homomalla

660365

Substrates: -
Products: -

arachidonic acid + O2

(5Z,8E,11Z,14Z)-8-hydroperoxyicosa-5,8,11,14-tetraenoic acid + (5Z,8E,11Z,14Z)-8-hydroxyicosa-5,8,11,14-tetraenoic acid

Mus musculus

439398

Substrates: arachidonic acid, enzyme activity only detectable after in vivo treatment with the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate)
Products: -

arachidonic acid + O2

(8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid

7 entries

arachidonic acid + O2

8R-hydroxy-eicosatetraenoic acid

Euphausia pacifica

A0A7G1H6X8

765778

Substrates: -
Products: -

docosahexaenoic acid + O2

10R-hydroxy-docosahexaenoic acid

Euphausia pacifica

A0A7G1H6X8

765778

Substrates: -
Products: -

docosahexaenoic acid + O2

Mus musculus

439401

Substrates: -
Products: -

eicosapentaenoic acid + O2

8R-hydroxy-eicosapentaenoic acid

Euphausia pacifica

A0A7G1H6X8

765778

Substrates: -
Products: -

eicosapentaenoic acid + O2

Mus musculus

439401

Substrates: -
Products: -

gamma-linoleic acid + O2

Mus musculus

439401

Substrates: -
Products: -

linoleic acid + O2

Mus musculus

439401

Substrates: poor substrate
Products: -

stearidonic acid + O2

6-hydroxystearidonic acid

Euphausia pacifica

A0A7G1H6X8

765778

Substrates: -
Products: -

additional information

5 entries