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1.13.11.40: arachidonate 8-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 8-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.40

Reaction

arachidonate
+
O2
=
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate

Synonyms

8(R)-lipoxygenase, 8-lipoxygenase, 8-LOX, 8R-lipoxygenase, 8R-LOX, 8S-lipoxygenase, 8S-LOX, allene oxide synthase-lipoxygenase protein, arachidonic acid C-8 lipoxygenase, eicosapentaenoic 8R-lipoxygenase, LOX-1, More

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.40 arachidonate 8-lipoxygenase

Substrates Products

Substrates Products on EC 1.13.11.40 - arachidonate 8-lipoxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(15S)-hydroperoxyeicosatetraenoic acid + O2
?
show the reaction diagram
-
-
-
-
?
(15S)-hydroxyeicosatetraenoic acid + O2
?
show the reaction diagram
-
-
-
-
?
(5Z,8Z,11Z,14Z)-nonadeca-5,8,11,14-tetraene-1,19-dioic acid + O2
?
show the reaction diagram
-
8-LOX tolerates a carboxylic group in the substrate-binding pocket
-
-
?
(8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid + O2
(8S,15S)-dihydroperoxy-5Z,9E,11Z,13E-eicosatetraenoic acid
show the reaction diagram
-
-
-
-
?
(8S)-hydroxyeicosatetraenoic acid + O2
?
show the reaction diagram
-
-
-
-
?
17S-hydroxy-docosa-4Z,7Z,10Z,13Z,15E,19Z-hexaenoic acid + O2
10R,17S-dihydroxy-docosa-4Z,7Z,11E,13Z,15E,19Z-hexaenoic acid
show the reaction diagram
-
-
-
?
2 arachidonic acid + 2 O2
8-hydroxy,9-oxo-eicosa-5Z,11Z,14Z-trienoic acid + 9-oxo-[8,12-cis]-prosta-5Z,10,14Z-trienoic acid + H2O
show the reaction diagram
5-hydroperoxy fatty acid + O2
leukotriene A4
show the reaction diagram
-
leukotriene A synthase activity, reaction rate is approximately 7% of arachidonate 8-lipoxygenation
-
-
?
5-hydroperoxyeicosatetraenoic acid + ?
leukotriene A4
show the reaction diagram
-
-
unstable product
?
alpha-linolenic acid + O2
?
show the reaction diagram
-
-
-
-
?
arachidonate + O2
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
show the reaction diagram
arachidonate + O2
(5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate
show the reaction diagram
-
-
-
-
?
arachidonate + O2
(5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
show the reaction diagram
-
-
-
-
?
arachidonic acid + O2
(5Z,8E,11Z,14Z)-8-hydroperoxyicosa-5,8,11,14-tetraenoic acid + (5Z,8E,11Z,14Z)-8-hydroxyicosa-5,8,11,14-tetraenoic acid
show the reaction diagram
-
arachidonic acid, enzyme activity only detectable after in vivo treatment with the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate)
-
-
?
arachidonic acid + O2
(8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid
show the reaction diagram
arachidonic acid + O2
8R-hydroxy-eicosatetraenoic acid
show the reaction diagram
-
-
-
?
docosahexaenoic acid + O2
10R-hydroxy-docosahexaenoic acid
show the reaction diagram
-
-
-
?
docosahexaenoic acid + O2
?
show the reaction diagram
-
-
-
-
?
eicosapentaenoic acid + O2
8R-hydroxy-eicosapentaenoic acid
show the reaction diagram
-
-
-
?
eicosapentaenoic acid + O2
?
show the reaction diagram
-
-
-
-
?
gamma-linoleic acid + O2
?
show the reaction diagram
-
-
-
-
?
linoleic acid + O2
?
show the reaction diagram
-
poor substrate
-
-
?
stearidonic acid + O2
6-hydroxystearidonic acid
show the reaction diagram
-
-
-
?
additional information
?
-