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1.13.11.46: 4-hydroxymandelate synthase

This is an abbreviated version!
For detailed information about 4-hydroxymandelate synthase, go to the full flat file.

Word Map on EC 1.13.11.46

Reaction

4-hydroxyphenylpyruvate
+
O2
=
(S)-4-hydroxymandelate
 +
CO2

Synonyms

(S)-hydroxymandelate synthase, 4-(S) hydroxymandelate synthase, 4-hydroxyphenylpyruvate dioxygenase II, HMS, HPDL, hydroxymandelate synthase, hydroxyphenylpyruvate dioxygenase-like

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.46 4-hydroxymandelate synthase

General Information

General Information on EC 1.13.11.46 - 4-hydroxymandelate synthase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
4-hydroxyphenylpyruvate dioxygenase, HPPD, EC 1.13.11.27, and hydroxymandelate synthase catalyze similar reactions using the same substrates, 4-hydroxyphenylpyruvate and dioxygen. Initially, both enzymes reduce and activate dioxygen in order to decarboxylate 4-hydroxyphenylpyruvate, yielding 4-hydroxyphenylacetate, CO2, and an activated oxo intermediate. Both enzymes then hydroxylate 4-hydroxyphenylacetate but do so in different positions
malfunction
additional information
-
molecular docking and modeling, molecular dynamics and simulations by classical molecular dynamics simulations, simulated HMS-Fe(IV)-O-HPA species, overview