1.13.11.6: 3-hydroxyanthranilate 3,4-dioxygenase

This is an abbreviated version, for detailed information about 3-hydroxyanthranilate 3,4-dioxygenase, go to the full flat file.

Reaction

3-Hydroxyanthranilate
+
O2
=
2-amino-3-carboxymuconate semialdehyde

Synonyms

3-HAD, 3-HAO, 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxidase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3HAO, EC 1.13.1.6, HAD, oxygenase, 3-hydroxyanthranilate 3,4-di-

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.6 - 3-hydroxyanthranilate 3,4-dioxygenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
Fe2+ chelator, 1 mM, complete inhibition
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide
carboxyl-directed reagent, 1 mM, 26% inhibition
2,2'-dipyridyl
Fe2+ chelator, 1 mM, complete inhibition
4,6-dibromo-3-hydroxyanthranilic acid
-
NCR-631, characterization of in vivo effects, reversible inhibition with short half-life following systematic administration
4-Bromo-3-hydroxyanthranilic acid
4-Chloro-3-hydroxyanthranilate
4-Chloro-3-hydroxyanthranilic acid
-
competitive
4-Fluoro-3-hydroxyanthranilic acid
-
competitive
6-chloro-3-hydroxyanthranilic acid
-
5-20 mM, loss of enzymatic activity as a function of the inhibitor concentration
acetaminophen
-
-
Acetylsalicylic acid
-
-
anthranilic acid
-
competitive inhibition
Co2+
1 mM, 92% inhibition
Cu2+
0.1 mM, complete inhibition
diethyl dicarbonate
modifies histidine residues of catechol dioxygenases, 1 mM, 70% inhibition
Dithionitrobenzoic acid
cysteine-directed reagent, 1 mM, complete inhibition
EDTA
1 mM, 99% inhibition
Fe3+
0.1 mM, 82% inhibition
iodoacetate
cysteine-directed reagent, 1 mM, 42% inhibition
Ni2+
1 mM, 82% inhibition
o-methoxybenzoylalanine
-
in whole-liver homogenates, but in purified enzyme preparations only in the presence of mitochondria
p-chloromercuribenzoate
-
-
p-Chloromercuriphenyl sulfonic acid
-
-
quinolinic acid
-
competitive inhibition
additional information
-