1.13.11.60: linoleate 8R-lipoxygenase
This is an abbreviated version!
For detailed information about linoleate 8R-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.60
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1.13.11.60
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hydroperoxide
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graminis
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gaeumannomyces
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oxylipins
-
dioxygenation
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antarafacial
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8r-hydroperoxylinoleic
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allene
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aspergilli
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suprafacial
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cyclooxygenases
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ppoas
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verticillioides
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take-all
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homolytic
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zymoseptoria
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ferryl
-
synthesis
- 1.13.11.60
- hydroperoxide
- graminis
-
gaeumannomyces
- oxylipins
-
dioxygenation
-
antarafacial
-
8r-hydroperoxylinoleic
-
allene
-
aspergilli
-
suprafacial
-
cyclooxygenases
-
ppoas
- verticillioides
-
take-all
-
homolytic
-
zymoseptoria
-
ferryl
- synthesis
Reaction
Synonyms
5,8-LDS, 5,8-linoleate diol synthase, 6,8-diol synthase, 6R,8R-linoleate diol synthase, 6R,8RLDS, 7,8-diol synthase, 7,8-LDS, 7,8-linoleate diol synthase, 8(R)-dioxygenase, 8,11-hydroperoxide isomerase, 8-DOX, 8R-dioxygenase, 8R-DOX, 8R-DOX-5,8-LDS, 8R-DOX-7,8-LDS, 8R-DOX-LDS, dioxygenase-cytochrome P450, DOX-CYP, EC 1.13.11.44, EGE82165, FOXB_09952, GLRG_10013, linoleate 7,8-LDS, linoleate 8,11-LDS, linoleate diol synthase, linoleic acid 8R-dioxygenase, ODH51007, orphan DOX-CYP, PpoA
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Reference on EC 1.13.11.60 - linoleate 8R-lipoxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Su, C.; Oliw, E.H.
Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as anovel hemoprotein
J. Biol. Chem.
271
14112-14118
1996
Gaeumannomyces graminis (Q9UUS2)
Su, C.; Sahlin, M.; Oliw, E.H.
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities
J. Biol. Chem.
273
20744-20751
1998
Gaeumannomyces graminis, Gaeumannomyces graminis (Q9UUS2), Gaeumannomyces graminis var. graminis, Gaeumannomyces graminis var. graminis (Q9UUS2)
Brodowsky, I.D.; Hamberg, M.; Oliw, E.H.
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-Hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-Hydroperoxylinoleic acid
J. Biol. Chem.
267
14738-14745
1992
Gaeumannomyces graminis
Hörnsten, L.; Su, C.; Osbourn, A.E.; Garosi, P.; Hellman, U.; Wernstedt, C.; Oliw, E.H.
Cloning of linoleate diol synthase reveals homology with prostaglandin H synthase
J. Biol. Chem.
274
28219-28224
1999
Gaeumannomyces graminis (Q9UUS2), Gaeumannomyces graminis
Brodowsky, I.D.; Hamberg, M.; Oliw, E.H.
BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis
Eur. J. Pharmacol.
254
43-47
1994
Gaeumannomyces graminis
Brodowsky, I.D.; Zhang, L.Y.; Oliw, E.H.; Hamberg, M.
Linoleic acid 8R-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Mechanism of catalysis and inhibition
Ann. N. Y. Acad. Sci.
744
314-316
1994
Gaeumannomyces graminis
Su, C.; Brodowsky, I.D.; Oliw, E.H.
Studies on linoleic acid 8R-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis
Lipids
30
43-50
1995
Gaeumannomyces graminis
Hamberg, M.; Zhang, L.Y.; Brodowsky, I.D.; Oliw, E.H.
Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: Stereochemistry of dioxygenase and hydroperoxide isomerase reactions
Arch. Biochem. Biophys.
309
77-80
1994
Gaeumannomyces graminis
Oliw, E.H.; Su, C.; Sahlin, M.
Catalytic properties of linoleate diol synthase of the fungus Gaeumannomyces graminis: A comparison with PGH synthases
Adv. Exp. Med. Biol.
469
679-685
1999
Gaeumannomyces graminis
Garscha, U.; Oliw, E.
Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase
Biochem. Biophys. Res. Commun.
373
579-583
2008
Gaeumannomyces graminis, Gaeumannomyces graminis var. avenae
Garscha, U.; Oliw, E.H.
Critical amino acids for the 8(R)-dioxygenase activity of linoleate diol synthase. A comparison with cyclooxygenases
FEBS Lett.
582
3547-3551
2008
Gaeumannomyces graminis (Q9UUS2)
Brodhun, F.; Goebel, C.; Hornung, E.; Feussner, I.
Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450
J. Biol. Chem.
284
11792-11805
2009
Aspergillus nidulans (Q6RET3)
Garscha, U.; Oliw, E.H.
Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity
J. Biol. Chem.
284
13755-13765
2009
Gaeumannomyces graminis
Hoffmann, I.; Jerneren, F.; Garscha, U.; Oliw, E.H.
Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase
Arch. Biochem. Biophys.
506
216-222
2010
Aspergillus fumigatus, Aspergillus fumigatus (C1KH66), Gaeumannomyces graminis
Jernerén, F.; Garscha, U.; Hoffmann, I.; Hamberg, M.; Oliw, E.H.
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus
Biochim. Biophys. Acta
1801
503-507
2010
Aspergillus clavatus
Hoffmann, I.; Oliw, E.H.
7,8- and 5,8-linoleate diol synthases support the heterolytic scission of oxygen-oxygen bonds by different amide residues
Arch. Biochem. Biophys.
539
87-91
2013
Aspergillus fumigatus, Gaeumannomyces graminis
Seo, M.J.; Shin, K.C.; An, J.U.; Kang, W.R.; Ko, Y.J.; Oh, D.K.
Characterization of a recombinant 7,8-linoleate diol synthase from Glomerella cingulate
Appl. Microbiol. Biotechnol.
100
3087-3099
2016
Colletotrichum gloeosporioides (A0A0S2SWE4), Colletotrichum gloeosporioides, Colletotrichum gloeosporioides KACC 40961 (A0A0S2SWE4)
Seo, M.J.; Kang, W.R.; Shin, K.C.; Oh, D.K.
Production of 7,8-dihydroxy unsaturated fatty acids from plant oils by whole recombinant cells expressing 7,8-linoleate diol synthase from Glomerella cingulata
J. Agric. Food Chem.
64
8555-8562
2016
Colletotrichum gloeosporioides (A0A0S2SWE4), Colletotrichum gloeosporioides, Colletotrichum gloeosporioides KACC 40961 (A0A0S2SWE4)
Sooman, L.; Oliw, E.H.
Discovery of a novel linoleate dioxygenase of Fusarium oxysporum and linoleate diol synthase of Colletotrichum graminicola
Lipids
50
1243-1252
2015
Colletotrichum graminicola (E3QVI1), Colletotrichum graminicola, Fusarium oxysporum (F9FU71), Fusarium oxysporum, Colletotrichum graminicola M1.001 (E3QVI1), Colletotrichum graminicola M1.001 / M2 / FGSC 10212 (E3QVI1), Fusarium oxysporum Fo5176 (F9FU71)
Oliw, E.H.
Linoleate diol synthase related enzymes of the human pathogens Histoplasma capsulatum and Blastomyces dermatitidis
Arch. Biochem. Biophys.
696
108669
2020
Paracoccidioides brasiliensis (A0A1E2Y953), Paracoccidioides brasiliensis, Blastomyces dermatitidis (F2TE78), Blastomyces dermatitidis
Oliw, E.H.
Polyunsaturated C18 fatty acids derivatized with Gly and Ile as an additional tool for studies of the catalytic evolution of fungal 8- and 9-dioxygenases
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1863
1378-1387
2018
Gaeumannomyces graminis (Q9UUS2)
Seo, M.J.; Kang, W.R.; Yang, E.J.; Shin, K.C.; Ko, Y.J.; Oh, D.K.
Molecular characterization of Penicillium oxalicum 6R,8R-linoleate diol synthase with new regiospecificity
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1864
577-586
2019
Penicillium oxalicum, Penicillium oxalicum KCTC 6440
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