1.13.11.60: linoleate 8R-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 8R-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.60

Reaction

linoleate
+
O2
=
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate

Synonyms

5,8-LDS, 5,8-linoleate diol synthase, 5,8-linoleate diol synthases, 7,8-diol synthase, 7,8-LDS, 7,8-linoleate diol synthase, 8(R)-dioxygenase, 8,11-hydroperoxide isomerase, 8-DOX, 8R-dioxygenase, 8R-DOX, dioxygenase-cytochrome P450, DOX-CYP, FOXB_09952, GLRG_10013, linoleate 7,8-LDS, linoleate 8,11-LDS, linoleate diol synthase, linoleic acid 8R-dioxygenase, orphan DOX-CYP, PpoA

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.60 linoleate 8R-lipoxygenase

Substrates Products

Substrates Products on EC 1.13.11.60 - linoleate 8R-lipoxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(11Z)-icos-11-enoic acid + O2
10-hydroperoxyeicosenoic acid
show the reaction diagram
-
-
-
?
(11Z)-icosa-11-enoate + O2
?
show the reaction diagram
-
-
-
?
(11Z,14Z)-icosa-11,14-dienoic acid + O2
(11Z,14Z)-10-hydroperoxyeicosa-11,14-dienoic acid
show the reaction diagram
-
-
-
?
(11Z,14Z)-icosa-11,14-dienoic acid + O2
?
show the reaction diagram
-
-
-
?
(11Z,14Z,17Z)-icosa-11,14,17-trienoic acid + O2
(11Z,14Z,17Z)-10-hydroperoxyeicosa-11,14,17-trienoic acid
show the reaction diagram
-
-
-
?
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + O2
(8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
show the reaction diagram
alpha-linolenate + O2
(8R,9Z,12Z)-8-hydroperoxy-9,12,15-octadecatrienoate
show the reaction diagram
-
-
-
?
alpha-linolenate + O2
(9Z,12Z,15Z)-7,8-dihydroperoxyoctadeca-9,12,15-trienoate
show the reaction diagram
via (9Z,12Z,15Z)-8-hydroperoxyoctadeca-9,12,15-trienoate, whole enzyme reaction
-
-
?
alpha-linolenate + O2
(9Z,12Z,15Z)-7,8-dihydroxyoctadeca-9,12,15-trienoic acid
show the reaction diagram
via (9Z,12Z,15Z)-8-hydroperoxyoctadeca-9,12,15-trienoic acid, best substrate with respect to whole enzyme activity
-
-
?
alpha-linolenate + O2
(9Z,12Z,15Z)-8-hydroperoxyoctadeca-9,12,15-trienoate
show the reaction diagram
dioxygenase reaction of the N-terminal domain
-
-
?
alpha-linolenate + O2
?
show the reaction diagram
-
-
-
?
alpha-linolenic acid + O2
?
show the reaction diagram
arachidonate + O2
(5Z,8Z,11Z,14Z)-8-hydroxyeicosa-5,8,11,14-tetraenoic acid
show the reaction diagram
-
-
-
?
arachidonic acid + O2
(R)-10-hydroxyarachidonic acid
show the reaction diagram
arachidonic acid + O2
8-hydroxyarachidonic acid
show the reaction diagram
-
-
-
?
dihomo-gamma-linolenate + O2
(8Z,11Z,14Z)-8-hydroxyeicosa-8,11,14-trienoic acid
show the reaction diagram
-
-
-
?
dihomo-gamma-linolenic acid + O2
8-hydroxydihomo-gamma-linolenic acid
show the reaction diagram
-
-
-
?
docosapentaenoic acid + O2
(R)-10-hydroperoxy-docosapentaenoic acid
show the reaction diagram
eicosadienoate + O2
(11Z,14Z)-8-hydroxyeicosa-11,14-dienoic acid
show the reaction diagram
-
-
-
?
eicosadienoic acid + O2
8-hydroxyeicosadienoic acid
show the reaction diagram
-
-
-
?
eicosenoate + O2
(11Z)-8-hydroxyeicosa-11-enoic acid
show the reaction diagram
-
-
-
?
eicosenoic acid + O2
8-hydroxyeicosenoic acid
show the reaction diagram
-
-
-
?
elaidate + O2
?
show the reaction diagram
-
-
-
?
gamma-linolenic acid + O2
(R)-8-hydroxy-gamma-linolenic acid
show the reaction diagram
linoleate
(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate
show the reaction diagram
linoleate + O2
(7S,8S)-7,8-dihydroxy-(9Z,12Z)-octadecadienoic acid
show the reaction diagram
linoleate + O2
(8R,10E,12Z)-8-hydroperoxy-10,12-octadecadienoate
show the reaction diagram
linoleate + O2
(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate
show the reaction diagram
linoleate + O2
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate
show the reaction diagram
linoleate + O2
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoic acid
show the reaction diagram
linoleate + O2
(R)-8-hydro(pero)xy-(9Z,12Z)-octadecadienoate + (8R,11R)-8,11-dihydro(pero)xy-(9Z,12Z)-octadecadienoate + (7R,8R)-7,8-dihydro(pero)xy-(9Z,12Z)-octadecadienoate
show the reaction diagram
-
-
-
?
oleate + O2
(9Z)-7,8-dihydroxyoctadeca-9-enoic acid
show the reaction diagram
oleate + O2
(9Z)-8-hydroperoxyoctadec-9-enoate
show the reaction diagram
oleate + O2
(9Z)-8-hydroperoxyoctadeca-9-enoic acid
show the reaction diagram
dioxygenase reaction of the N-terminal domain
-
-
?
oleate + O2
8-hydroperoxyoctadecamonoenoate + 7,8-dihydroxyoctadecamonoenoate
show the reaction diagram
-
-
-
?
palmitoleate + O2
(9Z)-5,8-dihydroxyhexadeca-9-enoic acid
show the reaction diagram
via (9Z)-dihydroperoxyhexadeca-9-enoate
-
-
?
palmitoleate + O2
(9Z)-8-hydroperoxyhexadec-9-enoate
show the reaction diagram
palmitoleate + O2
?
show the reaction diagram
-
-
-
?
additional information
?
-