1.13.11.77: oleate 10S-lipoxygenase
This is an abbreviated version!
For detailed information about oleate 10S-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.77
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1.13.11.77
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indoleamine
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oleic
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nostoc
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aeruginosa
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hydroperoxide
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l-tryptophan
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nicotinamide
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cyclooxygenases
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punctiforme
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indole
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2,3-dioxygenases
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nad+
- 1.13.11.77
- indoleamine
-
oleic
- nostoc
- aeruginosa
- hydroperoxide
- l-tryptophan
- nicotinamide
-
cyclooxygenases
- punctiforme
- indole
-
2,3-dioxygenases
- nad+
Reaction
Synonyms
(10S)-dioxygenase, (10S)-DOX, 10-dioxygenase, 10S-dioxygenase, 10S-DOX, 10S-DOX-like lipoxygenase, heme dioxygenase, linoleate 10S-dioxygenase, linoleate 10S-DOX, linoleate heme 10S-dioxygenase, LOX, Np-diox, Npun_R5469, oleate heme 10S-dioxygenase
ECTree
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Inhibitors
Inhibitors on EC 1.13.11.77 - oleate 10S-lipoxygenase
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alpha-calendic acid
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(8,10,12-ZEE)-conjugated linoleic acid derivative, strong inhibition
alpha-eleostearic acid
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(9,11,13-ZEE)-conjugated linoleic acid derivative, strong inhibition
beta-calendic acid
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(8,10,12-EEE)-conjugated linoleic acid derivative, complete inhibition
beta-eleostearic acid
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(9,11,13-EEE)-conjugated linoleic acid derivative, complete inhibition
jacaric acid
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(8,10,12-ZEZ)-conjugated linoleic acid derivative, low inhibition
Mg2+
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concentrations of Mg2+ higher than 1.25 mM inhibit activity strongly (90% of activity lost at 1.75 mM)
oleate
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at concentrations of oleate higher than 2.1 mM, the enzyme activity is inhibited by excess of substrate
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the enzyme is potently inhibited by 8,10,12- and 9,11,13-conjugated linoleic acid derivatives, found as impurities in the linoleic acid preparation from plant, overview
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