1.13.11.78: 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)

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For detailed information about 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming), go to the full flat file.

Reaction

Synonyms

(R)-1-hydroxy-2-aminoethylphosphonate oxygenase, ALOHA_HF130_AEPn_1_06c, diiron oxygenase, phnZ

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.78 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)

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Results	in table
37	AA Sequence
2	Cloned(Commentary)
1	Crystallization (Commentary)
6	General Information
2	Inhibitors
10	kcat/KM [mM/s]
11	KM Value [mM]
15	Metals/Ions
9	Natural Substrates/ Products (Substrates)
8	Organism
3	Pathway
2	pH Optimum
9	Protein Variants
2	Purification (Commentary)
3	Reaction
2	Reaction Type
8	Reference
13	Substrates and Products (Substrate)
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
10	Turnover Number [1/s]

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Reference on EC 1.13.11.78 - 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)

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729889

McSorley, F.R.; Wyatt, P.B.; Martinez, A.; DeLong, E.F.; Hove-Jensen, B.; Zechel, D.L.

PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond

J. Am. Chem. Soc.

134

8364-8367

2012

Escherichia coli

22564006

730821

Woersdoerfer, B.; Lingaraju, M.; Yennawar, N.H.; Boal, A.K.; Krebs, C.; Bollinger, J.M.; Pandelia, M.E.

Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

Proc. Natl. Acad. Sci. USA

110

18874-18879

2013

uncultured bacterium (D0E8I5), uncultured bacterium HF130 AEPn 1 (D0E8I5)

24198335

743680

van Staalduinen, L.M.; McSorley, F.R.; Schiessl, K.; Seguin, J.; Wyatt, P.B.; Hammerschmidt, F.; Zechel, D.L.; Jia, Z.

Crystal structure of PhnZ in complex with substrate reveals a di-iron oxygenase mechanism for catabolism of organophosphonates

Proc. Natl. Acad. Sci. USA

111

5171-5176

2014

uncultured bacterium HF130_AEPn_1 (D0E8I5)

24706911

743907

Zhao, C.; Chen, H.

Mechanism of organophosphonate catabolism by diiron oxygenase PhnZ a third iron-mediated O-O activation scenario in nature

ACS Catal.

3521-3531

2017

uncultured bacterium HF130_AEPn_1 (D0E8I5)

756059

Rajakovich, L.; Pandelia, M.; Mitchell, A.; Chang, W.; Zhang, B.; Boal, A.; Krebs, C.; Bollinger, J.

A new microbial pathway for organophosphonate degradation catalyzed by two previously misannotated non-heme-iron oxygenases

Biochemistry

1627-1647

2019

uncultured bacterium HF130_AEPn_1 (D0E8I5)

30789718

763794

Song, X.; Liu, J.; Wang, B.

Emergence of function from nonheme diiron oxygenases A quantum mechanical/molecular mechanical study of oxygen activation and organophosphonate catabolism mechanisms by PhnZ

ACS Catal.

2009-2022

2022

uncultured bacterium HF130_AEPn_1 (D0E8I5)

764169

Gama, S.R.; Lo, B.S.Y.; Seguin, J.; Pallitsch, K.; Hammerschmidt, F.; Zechel, D.L.

C-H bond cleavage is rate-limiting for oxidative C-P bond cleavage by the mixed valence diiron-dependent oxygenase PhnZ

Biochemistry

5271-5280

2019

uncultured bacterium

31046250